metoprolol [Ligand Id: 553] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL13 (Beatrolol, CGP-2175, Dl-metoprolol, Lopressidone, Metoprolol, Metoprolol slow release, (rs)-metoprolol, Seroken, Toprol-XL) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| ChEMBL | Antagonist activity against beta-1 adrenergic receptor (unknown origin) | B | 7.8 | pKd | 15.85 | nM | Kd | J Med Chem (2015) 58: 5691-5698 [PMID:25799158] |
| ChEMBL | DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) | B | 6.99 | pKi | 102 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | Displacement of [3H]CGP12177 from human beta1 adrenoceptor expressed in HEK293T cell membranes | B | 7.26 | pKi | 55 | nM | Ki | Bioorg Med Chem (2019) 27: 2959-2971 [PMID:31151791] |
| GtoPdb | - | - | 7.9 | pKi | - | - | - |
Eur J Pharmacol (1999) 367: 431-5 [PMID:10079020]; Br J Pharmacol (2005) 144: 317-22 [PMID:15655528]; J Pharmacol Exp Ther (1999) 290: 649-55 [PMID:10411574]; Naunyn Schmiedebergs Arch Pharmacol (2004) 369: 151-9 [PMID:14730417]; Mol Pharmacol (2003) 64: 1357-69 [PMID:14645666] |
| ChEMBL | DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) | B | 6.75 | pIC50 | 176 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| β1-adrenoceptor/Beta-1 adrenergic receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3440] [GtoPdb: 28] [UniProtKB: P34971] | ||||||||
| ChEMBL | Displacement of [3H]CGP12177 from mouse beta1 adrenoceptor expressed in HEK293T cell membranes | B | 7.31 | pKi | 49 | nM | Ki | Bioorg Med Chem (2019) 27: 2959-2971 [PMID:31151791] |
| β1-adrenoceptor/Beta-1 adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3252] [GtoPdb: 28] [UniProtKB: P18090] | ||||||||
| ChEMBL | Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria | F | 7.64 | pKd | 22.91 | nM | Kd | J Med Chem (1987) 30: 1003-1011 [PMID:2884312] |
| ChEMBL | Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria | F | 7.64 | pKd | 22.91 | nM | Kd | J Med Chem (1987) 30: 1003-1011 [PMID:2884312] |
| ChEMBL | Antagonist activity at rat beta1 adrenoceptor | B | 7.64 | pKd | 22.91 | nM | Kd | J Med Chem (2016) 59: 8712-8756 [PMID:27299736] |
| ChEMBL | Antagonist activity at rat beta-1 adrenergic receptor Y356A mutant expressed in CHO cells | F | 5.3 | pKi | 5011.87 | nM | Ki | J Med Chem (2006) 49: 3467-3477 [PMID:16759089] |
| ChEMBL | Antagonist activity at rat beta-1 adrenergic receptor Y356F mutant expressed in CHO cells | F | 5.6 | pKi | 2511.89 | nM | Ki | J Med Chem (2006) 49: 3467-3477 [PMID:16759089] |
| ChEMBL | Antagonist activity at rat beta-1 adrenergic receptor S190A mutant expressed in CHO cells | F | 5.6 | pKi | 2511.89 | nM | Ki | J Med Chem (2006) 49: 3467-3477 [PMID:16759089] |
| ChEMBL | Antagonist activity at rat beta-1 adrenergic receptor W134A mutant expressed in CHO cells | F | 6.2 | pKi | 630.96 | nM | Ki | J Med Chem (2006) 49: 3467-3477 [PMID:16759089] |
| ChEMBL | Antagonist activity at rat wild type beta-1 adrenergic receptor expressed in CHO cells | F | 6.4 | pKi | 398.11 | nM | Ki | J Med Chem (2006) 49: 3467-3477 [PMID:16759089] |
| Beta-1 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5471] [UniProtKB: B0FL73] | ||||||||
| ChEMBL | Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea | F | 6.14 | pKd | 724.44 | nM | Kd | J Med Chem (1987) 30: 1003-1011 [PMID:2884312] |
| ChEMBL | Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteria | F | 7.83 | pKd | 14.79 | nM | Kd | J Med Chem (1982) 25: 931-936 [PMID:6126588] |
| ChEMBL | In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea pig atrial preparations | B | 7.83 | pKd | 14.79 | nM | Kd | J Med Chem (1983) 26: 950-957 [PMID:6134834] |
| ChEMBL | In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated guinea pig atria | B | 7.83 | pKd | 14.79 | nM | Kd | J Med Chem (1986) 29: 1065-1080 [PMID:2872332] |
| ChEMBL | Tested for beta-2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of guinea pigs | F | 6.49 | pIC50 | 320 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 1273-1274 |
| ChEMBL | Tested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigs | F | 6.72 | pIC50 | 190 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 1273-1274 |
| β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
| ChEMBL | Displacement of [3H]DHA from inactive/G protein-uncoupled human beta2-AR expressed in CHO cell membranes assessed as intrinsic Kd by liquid scintillation counting | B | 4.81 | pKd | 15500 | nM | Kd | J Med Chem (2016) 59: 5780-5789 [PMID:27239696] |
| ChEMBL | Displacement of [3H]DHA from inactive/G protein-uncoupled human beta2-AR expressed in CHO cell membranes by liquid scintillation counting | B | 6.89 | pKd | 130 | nM | Kd | J Med Chem (2016) 59: 5780-5789 [PMID:27239696] |
| ChEMBL | DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) | B | 5.75 | pKi | 1769 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | Displacement of [3H]CGP12177 from human beta2 adrenoceptor expressed in CHO cell membranes | B | 6.66 | pKi | 220 | nM | Ki | Bioorg Med Chem (2019) 27: 2959-2971 [PMID:31151791] |
| GtoPdb | - | - | 6.9 | pKi | - | - | - |
Eur J Pharmacol (1999) 367: 431-5 [PMID:10079020]; Br J Pharmacol (2005) 144: 317-22 [PMID:15655528] |
| ChEMBL | DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) | B | 5.59 | pIC50 | 2573 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Beta-2 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4] | ||||||||
| ChEMBL | Beta-2 adrenergic receptor antagonistic activity on guinea pig tracheal chains | F | 6.79 | pKd | 162.18 | nM | Kd | J Med Chem (1982) 25: 931-936 [PMID:6126588] |
| ChEMBL | In vitro beta-2 adrenergic receptor activity was determined by measuring inhibition of the isoproterenol induced relaxation in isolated guinea pig tracheal chains contracted with PGF2-alpha | B | 6.79 | pKd | 162.18 | nM | Kd | J Med Chem (1983) 26: 950-957 [PMID:6134834] |
| ChEMBL | In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha contracted guinea pig trachea | B | 6.79 | pKd | 162.18 | nM | Kd | J Med Chem (1986) 29: 1065-1080 [PMID:2872332] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
| ChEMBL | Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement | B | 5 | pKi | 10000 | nM | Ki | J Med Chem (1996) 39: 126-134 [PMID:8568799] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
