compound 5g [PMID: 21571530] [Ligand Id: 5514] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2153581 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| oxoglutarate receptor/2-oxoglutarate receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2150840] [GtoPdb: 162] [UniProtKB: Q96P68] | ||||||||
| ChEMBL | Antagonist activity at human GPR99 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level at by FLIPR assay | F | 4.52 | pIC50 | >30000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 3596-3602 [PMID:21571530] |
| succinate receptor/Succinate receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2150838] [GtoPdb: 166] [UniProtKB: Q9BXA5] | ||||||||
| ChEMBL | Antagonist activity at human GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay | F | 7.46 | pIC50 | 35 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 3596-3602 [PMID:21571530] |
| GtoPdb | - | - | 7.46 | pIC50 | 35 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 3596-602 [PMID:21571530] |
| succinate receptor/Succinate receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2150839] [GtoPdb: 166] [UniProtKB: Q6IYF9] | ||||||||
| ChEMBL | Antagonist activity at rat GPR91 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level by FLIPR assay | F | 6.87 | pIC50 | 135 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 3596-3602 [PMID:21571530] |
| GtoPdb | - | - | 6.87 | pIC50 | 135 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 3596-602 [PMID:21571530] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
