bupranolol [Ligand Id: 550] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL305380 (KL-255 [AS HYDROCHLORIDE], Bupranolol, Bupranol, B 1312 [AS HYDROCHLORIDE], Bupranolol hydrochloride)
  • β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588]
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  • β2-adrenoceptor in Human [GtoPdb: 29] [UniProtKB: P07550]
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  • β3-adrenoceptor in Human [GtoPdb: 30] [UniProtKB: P13945]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588]
GtoPdb - - 9 pKi - - - Eur J Pharmacol (1999) 367: 431-5 [PMID:10079020];
J Pharmacol Exp Ther (1999) 290: 649-55 [PMID:10411574]
β2-adrenoceptor in Human [GtoPdb: 29] [UniProtKB: P07550]
GtoPdb - - 9.1 pKi - - - Eur J Pharmacol (1999) 367: 431-5 [PMID:10079020];
J Pharmacol Exp Ther (1999) 290: 649-55 [PMID:10411574]
β3-adrenoceptor in Human [GtoPdb: 30] [UniProtKB: P13945]
GtoPdb - - 7.3 pKi - - - Eur J Pharmacol (1999) 367: 431-5 [PMID:10079020];
J Pharmacol Exp Ther (1999) 290: 649-55 [PMID:10411574];
Eur J Pharmacol (1995) 291: 359-66 [PMID:8719421];
Mol Pharmacol (1993) 44: 1094-104 [PMID:7903415]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]