tandospirone [Ligand Id: 55] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL274047 (Tandospirone) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Binding affinity to Dopamine receptor D2 was determined | B | 6.34 | pKi | 460 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1141-1144 [PMID:11354362] |
| D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
| ChEMBL | Binding affinity to Dopamine receptor D4 was determined | B | 8.14 | pKi | 7.2 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1141-1144 [PMID:11354362] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Binding affinity to 5-hydroxytryptamine 1A receptor was determined | B | 7.49 | pKi | 32 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1141-1144 [PMID:11354362] |
| GtoPdb | - | - | 8.2 | pKi | - | - | - | Eur J Pharmacol (1998) 355: 245-56 [PMID:9760039] |
| ChEMBL | Agonist activity at 5HT1A receptor (unknown origin) | F | 8.24 | pKi | 5.8 | nM | Ki | Eur J Med Chem (2018) 145: 74-85 [PMID:29324345] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
| ChEMBL | In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue. | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (1988) 31: 1382-1392 [PMID:2898533] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
