(±)-adrenaline [Ligand Id: 509] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1740 (Dl-adrenaline, Epinephrine, dl-, Epinephrine dl-form, Epinephrine racemic, Epirenamine, Racepinefrine, Racepinephrine, Vaponefrin)
  • α2B-adrenoceptor in Human [GtoPdb: 26] [UniProtKB: P18089]
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  • α2C-adrenoceptor in Human [GtoPdb: 27] [UniProtKB: P18825]
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  • β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588]
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  • β3-adrenoceptor in Human [GtoPdb: 30] [UniProtKB: P13945]
  • β3-adrenoceptor in Mouse [GtoPdb: 30] [UniProtKB: P25962]
  • β3-adrenoceptor in Rat [GtoPdb: 30] [UniProtKB: P26255]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
α2B-adrenoceptor in Human [GtoPdb: 26] [UniProtKB: P18089]
GtoPdb - - 6.2 pKi - - - Biochem Pharmacol (1998) 55: 1035-43 [PMID:9605427]
α2C-adrenoceptor in Human [GtoPdb: 27] [UniProtKB: P18825]
GtoPdb - - 6.2 pKi - - - Biochem Pharmacol (1998) 55: 1035-43 [PMID:9605427]
β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588]
GtoPdb - - 6 pKi - - - Proc Natl Acad Sci USA (1988) 85: 9494-8 [PMID:2849109]
β3-adrenoceptor in Human [GtoPdb: 30] [UniProtKB: P13945]
GtoPdb - - 4.7 pKi - - - Eur J Pharmacol (1995) 291: 359-66 [PMID:8719421];
Mol Pharmacol (1993) 44: 1094-104 [PMID:7903415];
Naunyn Schmiedebergs Arch Pharmacol (2004) 369: 151-9 [PMID:14730417]
β3-adrenoceptor in Mouse [GtoPdb: 30] [UniProtKB: P25962]
GtoPdb - - 5.3 pKi - - - Eur J Pharmacol (1995) 291: 359-66 [PMID:8719421]
β3-adrenoceptor in Rat [GtoPdb: 30] [UniProtKB: P26255]
GtoPdb - - 5.3 pKi - - - Eur J Pharmacol (1995) 291: 359-66 [PMID:8719421]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]