(±)-adrenaline [Ligand Id: 509] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1740 (Dl-adrenaline, Epinephrine, dl-, Epinephrine dl-form, Epinephrine racemic, Epirenamine, Racepinefrina, Racepinefrine, Racepinephrine)
  • α2B-adrenoceptor in Human [GtoPdb: 26] [UniProtKB: P18089]
Created with Highcharts 10.3.3ValuesChart context menuα2B-adrenoceptorpKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • α2C-adrenoceptor in Human [GtoPdb: 27] [UniProtKB: P18825]
Created with Highcharts 10.3.3ValuesChart context menuα2C-adrenoceptorpKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588]
Created with Highcharts 10.3.3ValuesChart context menuβ1-adrenoceptorpKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • β3-adrenoceptor in Human [GtoPdb: 30] [UniProtKB: P13945]
  • β3-adrenoceptor in Mouse [GtoPdb: 30] [UniProtKB: P25962]
  • β3-adrenoceptor in Rat [GtoPdb: 30] [UniProtKB: P26255]
Created with Highcharts 10.3.3ValuesChart context menuβ3-adrenoceptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd MousepKi MousepIC50 MousepEC50 MousepKd RatpKi RatpIC50 RatpEC50 Rat0123456Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
α2B-adrenoceptor in Human [GtoPdb: 26] [UniProtKB: P18089]
GtoPdb - - 6.2 pKi - - - Biochem Pharmacol (1998) 55: 1035-43 [PMID:9605427]
α2C-adrenoceptor in Human [GtoPdb: 27] [UniProtKB: P18825]
GtoPdb - - 6.2 pKi - - - Biochem Pharmacol (1998) 55: 1035-43 [PMID:9605427]
β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588]
GtoPdb - - 6 pKi - - - Proc Natl Acad Sci USA (1988) 85: 9494-8 [PMID:2849109]
β3-adrenoceptor in Human [GtoPdb: 30] [UniProtKB: P13945]
GtoPdb - - 4.7 pKi - - - Eur J Pharmacol (1995) 291: 359-66 [PMID:8719421];
Mol Pharmacol (1993) 44: 1094-104 [PMID:7903415];
Naunyn Schmiedebergs Arch Pharmacol (2004) 369: 151-9 [PMID:14730417]
β3-adrenoceptor in Mouse [GtoPdb: 30] [UniProtKB: P25962]
GtoPdb - - 5.3 pKi - - - Eur J Pharmacol (1995) 291: 359-66 [PMID:8719421]
β3-adrenoceptor in Rat [GtoPdb: 30] [UniProtKB: P26255]
GtoPdb - - 5.3 pKi - - - Eur J Pharmacol (1995) 291: 359-66 [PMID:8719421]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]