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ChEMBL ligand: CHEMBL432 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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TA1 receptor/Trace amine-associated receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5857] [GtoPdb: 364] [UniProtKB: Q96RJ0] | ||||||||
ChEMBL | Agonist activity at recombinant human TAAR1 expressed in CHO-K1 cells assessed as increase in intracellular cAMP incubated for 30 mins by HTRF analysis | F | 4.91 | pEC50 | 12200 | nM | EC50 | ACS Med Chem Lett (2022) 13: 92-98 [PMID:35047111] |
β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
GtoPdb | - | - | 6 | pKi | - | - | - | Proc Natl Acad Sci USA (1988) 85: 9494-8 [PMID:2849109] |
β2-adrenoceptor in Human [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
GtoPdb | - | - | 5.4 | pKi | - | - | - | Mol Pharmacol (2004) 65: 1181-90 [PMID:15102946] |
D1 receptor in Human [GtoPdb: 214] [UniProtKB: P21728] | ||||||||
GtoPdb | - | - | 4.3 | pKi | - | - | - | Nature (1991) 350: 614-9 [PMID:1826762] |
D5 receptor in Human [GtoPdb: 218] [UniProtKB: P21918] | ||||||||
GtoPdb | - | - | 4.9 | pKi | - | - | - | Nature (1991) 350: 614-9 [PMID:1826762] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]