ChEMBL ligand: CHEMBL485862
A1 receptor/Adenosine receptor A1 in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] There should be some charts here, you may need to enable JavaScript!
A2A receptor/Adenosine receptor A2a in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] There should be some charts here, you may need to enable JavaScript!
A2B receptor/Adenosine receptor A2b in Human [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] There should be some charts here, you may need to enable JavaScript!
A3 receptor/Adenosine receptor A3 in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
A1 receptor/Adenosine receptor A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL	Antagonist activity against human adenosine A1 receptor	F	6.35	pKi	450	nM	Ki	Eur J Med Chem (2010) 45: 3459-3471 [PMID:20537438]
ChEMBL	Binding affinity to human adenosine A1 receptor	B	7.43	pKi	37	nM	Ki	J Med Chem (2009) 52: 3994-4006 [PMID:19569717]
ChEMBL	Binding affinity to human adenosine A1 receptor	B	7.43	pKi	37	nM	Ki	J Med Chem (2012) 55: 797-811 [PMID:22148859]
A2A receptor/Adenosine receptor A2a in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL	Binding affinity to human adenosine A2A receptor	B	6.48	pKi	328	nM	Ki	J Med Chem (2009) 52: 3994-4006 [PMID:19569717]
ChEMBL	Antagonist activity against human adenosine A2A receptor	F	6.48	pKi	328	nM	Ki	Eur J Med Chem (2010) 45: 3459-3471 [PMID:20537438]
ChEMBL	Binding affinity to human adenosine A2A receptor	B	6.48	pKi	328	nM	Ki	J Med Chem (2012) 55: 797-811 [PMID:22148859]
A2B receptor/Adenosine receptor A2b in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
GtoPdb	-	-	9.3	pKi	-	-	-	Biochem Pharmacol (2004) 68: 305-12 [PMID:15194002]
ChEMBL	Antagonist activity against human adenosine A2B receptor	F	9.3	pKi	0.5	nM	Ki	Eur J Med Chem (2010) 45: 3459-3471 [PMID:20537438]
ChEMBL	Binding affinity to human recombinant A2B receptor expressed in HEK293 cell membranes	B	9.3	pKi	0.5	nM	Ki	J Med Chem (2019) 62: 9315-9330 [PMID:31557025]
ChEMBL	Antagonist activity at human A2B receptor	B	9.3	pKi	0.5	nM	Ki	J Med Chem (2021) 64: 458-480 [PMID:33372800]
ChEMBL	Binding affinity to human adenosine A2B receptor	B	9.39	pKi	0.41	nM	Ki	J Med Chem (2009) 52: 3994-4006 [PMID:19569717]
ChEMBL	Binding affinity to human adenosine A2B receptor	B	9.4	pKi	0.4	nM	Ki	J Med Chem (2012) 55: 797-811 [PMID:22148859]
A3 receptor/Adenosine receptor A3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
ChEMBL	Binding affinity to human adenosine A3 receptor	B	6.35	pKi	450	nM	Ki	J Med Chem (2009) 52: 3994-4006 [PMID:19569717]
ChEMBL	Antagonist activity against human adenosine A3 receptor	F	6.35	pKi	450	nM	Ki	Eur J Med Chem (2010) 45: 3459-3471 [PMID:20537438]
ChEMBL	Binding affinity to human adenosine A3 receptor	B	6.35	pKi	450	nM	Ki	J Med Chem (2012) 55: 797-811 [PMID:22148859]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]