zaleplon [Ligand Id: 4345] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1521 (CL 284,846, CL-284846, L-846, L846, LJC 10846, LJC-10846, SKP-1041, Sonata, ZAL-846, Zaleplon, Zaleplon civ, Zerene) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GABAA receptor α1 subunit/GABAA receptor γ2 subunit/GABAA receptor β2 subunit/GABA-A receptor; alpha-1/beta-2/gamma-2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095172] [GtoPdb: 404, 414, 411] [UniProtKB: P14867, P18507, P47870] | ||||||||
| ChEMBL | Modulation of human GABA-A alpha1beta2gamma2 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currents | B | 6.54 | pEC50 | 290 | nM | EC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| GABAA receptor γ2 subunit/GABAA receptor β3 subunit/GABAA receptor α2 subunit/GABA-A receptor; alpha-2/beta-3/gamma-2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094130] [GtoPdb: 414, 412, 405] [UniProtKB: P18507, P28472, P47869] | ||||||||
| ChEMBL | Modulation of human GABAA alpha2beta3gamma2 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currents | B | 5.79 | pEC50 | 1630 | nM | EC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| GABAA receptor γ2 subunit/GABAA receptor β3 subunit/GABAA receptor α3 subunit/GABA-A receptor; alpha-3/beta-3/gamma-2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094120] [GtoPdb: 414, 412, 406] [UniProtKB: P18507, P28472, P34903] | ||||||||
| ChEMBL | Modulation of human GABAA alpha3beta3gamma2 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currents | B | 6 | pEC50 | >1000 | nM | EC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| GABAA receptor β3 subunit/GABAA receptor α5 subunit/GABAA receptor γ3 subunit/Gamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3885577] [GtoPdb: 412, 408, 415] [UniProtKB: P28472, P31644, Q99928] | ||||||||
| ChEMBL | Modulation of human GABAA alpha5beta3gamma3 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currents | B | 6 | pEC50 | >1000 | nM | EC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
