LY392098 [Ligand Id: 4248] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL341748 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GluA4/Glutamate receptor ionotropic, AMPA 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3190] [GtoPdb: 447] [UniProtKB: P48058] | ||||||||
| ChEMBL | Tested for potentiation towards human iGluR4 receptor expressed in HEK293 cells | F | 5.36 | pEC50 | 4400 | nM | EC50 | J Med Chem (2000) 43: 4354-4358 [PMID:11087558] |
| GtoPdb | - | - | 6.7 | pEC50 | 200 | nM | EC50 | Neuropharmacology (2001) 40: 976-83 [PMID:11406188] |
| GluA1 in Human [GtoPdb: 444] [UniProtKB: P42261] | ||||||||
| GtoPdb | - | - | 5.75 | pEC50 | 1770 | nM | EC50 | Neuropharmacology (2001) 40: 976-83 [PMID:11406188] |
| GluA2 in Human [GtoPdb: 445] [UniProtKB: P42262] | ||||||||
| GtoPdb | - | - | 6.66 | pEC50 | 220 | nM | EC50 | Neuropharmacology (2001) 40: 976-83 [PMID:11406188] |
| GluA3 in Human [GtoPdb: 446] [UniProtKB: P42263] | ||||||||
| GtoPdb | - | - | 5.72 | pEC50 | 1890 | nM | EC50 | Neuropharmacology (2001) 40: 976-83 [PMID:11406188] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
