AMG628 [Ligand Id: 4130] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL226574 (AMG-628) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TRPV1/Vanilloid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5102] [GtoPdb: 507] [UniProtKB: O35433] | ||||||||
| GtoPdb | - | - | 8.4 | pIC50 | 3.7 | nM | IC50 | J Med Chem (2007) 50: 3528-39 [PMID:17585751] |
| ChEMBL | Inhibition of rat TRPV1 expressed in CHO cells assessed as capsaicin-induced Ca2+ influx | B | 8.43 | pIC50 | 3.7 | nM | IC50 | J Med Chem (2007) 50: 3528-3539 [PMID:17585751] |
| ChEMBL | Antagonist activity at rat TRPV1 | B | 8.43 | pIC50 | 3.7 | nM | IC50 | J Med Chem (2021) 64: 14046-14128 [PMID:34591488] |
| ChEMBL | Inhibition of rat TRPV1 expressed in CHO cells assessed as acid-induced Ca2+ influx | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2007) 50: 3528-3539 [PMID:17585751] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
