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ChEMBL ligand: CHEMBL190 (Accurbron, Aerolate, Aerolate iii, Aerolate jr, Aerolate sr, Aquaphyllin, Bronkodyl, Dimethylxanthine, Doxophylline metabolite m3, Duraphyl, Elixicon, Elixomin, Elixophyllin, Elixophyllin sr, Labid, Lanophyllin, Lasma, NSC-2066, NSC-757346, Nuelin, Nuelin sa, Nuelin sa-250, Pro-vent, Quibron, Quibron-t, Quibron-t/sr, Respbid, Slo-bid, Slo-phyllin, Somophyllin-crt, Somophyllin-t, Sustaire, Theo-24, Theobid, Theobid jr., Theochron, Theocin, Theoclear-100, Theoclear-200, Theoclear-80, Theoclear l.a.-130, Theoclear l.a.-260, Theo-dur, Theograd, Theolair, Theolair-sr, Theolixir, Theophyl, Theophyl-225, Theophylline, Theophylline anhydrous, Theophylline, anhydrous, Theophylline,anhydrous, Theophylline melting point standard, Theophylline monohydrate, Theophylline-sr, Theophyl-sr, Theovent, T-phyl, Uni-dur, Uniphyl, Uniphyllin continus) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
ChEMBL | Dissociation constant against Adenosine A1 receptor | B | 4.92 | pKd | 12000 | nM | Kd | J Med Chem (2005) 48: 2026-2035 [PMID:15771445] |
ChEMBL | Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in CHO-A1 cell membrane | B | 5 | pKi | 10100 | nM | Ki | Bioorg Med Chem (2010) 18: 2081-2088 [PMID:20202853] |
ChEMBL | DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) | B | 5 | pKi | 9977 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | Binding affinity to adenosine A1 receptor | B | 5.07 | pKi | 8500 | nM | Ki | J Nat Prod (2000) 63: 315-317 [PMID:10757709] |
ChEMBL | Displacement of [3H]CPX from human adenosine A3 receptor expressed in CHO cells | B | 5.16 | pKi | 6920 | nM | Ki | J Med Chem (2006) 49: 3682-3692 [PMID:16759111] |
ChEMBL | Displacement of [3H]CCPA from human adenosine receptor A1 expressed in CHO cell membranes by radioligand competition assay | B | 5.17 | pKi | 6770 | nM | Ki | J Med Chem (2020) 63: 2577-2587 [PMID:31738058] |
ChEMBL | Displacement of [3H]CCPA from human adenosine receptor A1 expressed in CHO cell membranes incubated for 90 mins by radioligand competition assay | B | 5.17 | pKi | 6770 | nM | Ki | Eur J Med Chem (2020) 186: 111879-111879 [PMID:31780082] |
ChEMBL | Antagonist activity at adenosine A1 receptor (unknown origin) | F | 5.17 | pKi | 6770 | nM | Ki | Eur J Med Chem (2022) 227: 113907-113907 [PMID:34695776] |
ChEMBL | Binding affinity to human adenosine A1 receptor | B | 5.17 | pKi | 6770 | nM | Ki | Bioorg Med Chem (2010) 18: 2195-2203 [PMID:20188574] |
ChEMBL | Binding affinity to human adenosine A1 receptor | B | 5.17 | pKi | 6770 | nM | Ki | Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167] |
ChEMBL | Displacement of [3H]CCPA from human A1 adenosine receptor expressed in CHO cells | B | 5.17 | pKi | 6770 | nM | Ki | Medchemcomm (2016) 7: 845-852 |
ChEMBL | Binding affinity to human adenosine A1 receptor by radioligand displacement assay | B | 5.17 | pKi | 6770 | nM | Ki | Medchemcomm (2018) 9: 951-962 [PMID:30108984] |
GtoPdb | - | - | 5.2 | pKi | - | - | - |
J Biol Chem (1994) 269: 32077-84 [PMID:7798201]; Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 1-9 [PMID:9459566]; Biochem Pharmacol (2005) 70: 1601-12 [PMID:16219300]; Biochem Pharmacol (2001) 62: 1163-73 [PMID:11705449] |
ChEMBL | Binding affinity to human adenosine A1 receptor | B | 5.21 | pKi | 6200 | nM | Ki | J Med Chem (2009) 52: 3994-4006 [PMID:19569717] |
ChEMBL | Displacement of [3H]CHA from cloned human adenosine A1 receptor expressed in CHO cells | B | 5.21 | pKi | 6200 | nM | Ki | J Med Chem (2005) 48: 7932-7945 [PMID:16335918] |
ChEMBL | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells | B | 5.21 | pKi | 6200 | nM | Ki | J Med Chem (2006) 49: 3916-3925 [PMID:16789747] |
ChEMBL | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells | B | 5.21 | pKi | 6200 | nM | Ki | J Med Chem (2007) 50: 4061-4074 [PMID:17665891] |
ChEMBL | Displacement of [3H]DPCPX from human cloned adenosine A1 receptor expressed in CHO cells | B | 5.21 | pKi | 6200 | nM | Ki | J Med Chem (2009) 52: 2407-2419 [PMID:19301821] |
ChEMBL | Displacement of [125I]DPCPX from human cloned adenosine A1 receptor expressed in CHO cells | B | 5.21 | pKi | 6200 | nM | Ki | Bioorg Med Chem (2008) 16: 6086-6102 [PMID:18468446] |
ChEMBL | Binding affinity against human adenosine A1 receptor expressed in CHO cells using [3H]CHA | B | 5.21 | pKi | 6200 | nM | Ki | J Med Chem (2004) 47: 3580-3590 [PMID:15214785] |
ChEMBL | Binding affinity for adenosine A1 receptor by using as [3H]CPX iradioligand n membranes from Chinese hamster ovary cells | B | 9.22 | pKi | 0.6 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 609-612 [PMID:15664822] |
ChEMBL | DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) | B | 4.77 | pIC50 | 17104 | nM | IC50 | DrugMatrix in vitro pharmacology data |
Adenosine A1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4975] [UniProtKB: P28190] | ||||||||
ChEMBL | Antagonist binding of N6-cyclohexyl-[3H]-adenosine to bovine brain | B | 4.7 | pKi | 20000 | nM | Ki | J Med Chem (1982) 25: 197-207 [PMID:6279840] |
ChEMBL | Affinity to A1 adenosine receptor was measured by the displacement of [3H]PIA in bovine brain cortical membrane | B | 5.07 | pKi | 8500 | nM | Ki | J Med Chem (1994) 37: 2970-2975 [PMID:8071944] |
ChEMBL | Displacement of [3H]CPX from adenosine A1 receptor of calf brain cortical membrane | B | 5.22 | pKi | 6000 | nM | Ki | J Med Chem (1991) 34: 1202-1206 [PMID:2002461] |
ChEMBL | Displacement of [3H]CHA from adenosine A1 receptor in bovine brain membranes | B | 5.42 | pKi | 3800 | nM | Ki | J Med Chem (2000) 43: 3118-3124 [PMID:10956220] |
ChEMBL | Displacement of [3H]CHA from adenosine A1 receptor in bovine cerebral cortical membranes | B | 5.42 | pKi | 3800 | nM | Ki | J Med Chem (2005) 48: 7932-7945 [PMID:16335918] |
ChEMBL | Displacement of [3H]DPCPX from adenosine A1 receptor in bovine brain membranes | B | 5.42 | pKi | 3800 | nM | Ki | J Med Chem (2006) 49: 3916-3925 [PMID:16789747] |
ChEMBL | Displacement of [3H]DPCPX from bovine brain cortical membrane adenosine A1 receptor | B | 5.42 | pKi | 3800 | nM | Ki | J Med Chem (2009) 52: 2407-2419 [PMID:19301821] |
ChEMBL | Displacement of [125I]DPCPX from adenosine A1 receptor in bovine brain membrane | B | 5.42 | pKi | 3800 | nM | Ki | Bioorg Med Chem (2008) 16: 6086-6102 [PMID:18468446] |
ChEMBL | Binding affinity towards adenosine A1 receptor of bovine brain membrane using [3H]-CHA at 20 uM | B | 5.42 | pKi | 3800 | nM | Ki | J Med Chem (2000) 43: 1158-1164 [PMID:10737748] |
ChEMBL | Binding affinity against adenosine A1 receptor in bovine brain membranes by [3H]CHA displacement. | B | 5.42 | pKi | 3800 | nM | Ki | J Med Chem (2004) 47: 3580-3590 [PMID:15214785] |
ChEMBL | Binding affinity against bovine brain adenosine A1 receptor using N6-[3H]- cyclohexyladenosine | B | 4.9 | pIC50 | 12700 | nM | IC50 | J Med Chem (1985) 28: 1071-1079 [PMID:2991519] |
ChEMBL | Binding affinity against bovine brain adenosine A1 receptor using N6-[3H]- cyclohexyladenosine | B | 5.61 | pIC50 | 2430 | nM | IC50 | J Med Chem (1985) 28: 1071-1079 [PMID:2991519] |
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
ChEMBL | Displacement of [3H]CHA from adenosine A1 receptor in rat brain cortical membrane | B | 4.59 | pKi | 26000 | nM | Ki | J Nat Prod (1998) 61: 301-305 [PMID:9514015] |
ChEMBL | Ability to inhibit binding of [3H]CHA to adenosine A1 receptor in rat brain cortical membranes. | B | 4.77 | pKi | 17000 | nM | Ki | J Med Chem (1997) 40: 4396-4405 [PMID:9435909] |
ChEMBL | Binding affinity to rat adenosine A1 receptor | B | 4.85 | pKi | 14000 | nM | Ki | Bioorg Med Chem (2010) 18: 2195-2203 [PMID:20188574] |
ChEMBL | Binding affinity at Adenosine A1 receptor in rat brain cortical membrane using [3H]N6-R-phenylisopropyladenosine (R-PIA) as radioligand | B | 4.85 | pKi | 14000 | nM | Ki | J Med Chem (1993) 36: 3341-3349 [PMID:8230124] |
ChEMBL | Binding of 1 nM [3H]CHA to Adenosine A1 receptor of rat cerebral cortical membranes | B | 4.85 | pKi | 14000 | nM | Ki | J Med Chem (1988) 31: 2034-2039 [PMID:3172141] |
ChEMBL | Binding affinity to rat adenosine A1 receptor | B | 4.85 | pKi | 14000 | nM | Ki | Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167] |
ChEMBL | Ability to inhibit binding of 1 nM [3H]cyclohexyladenosine to adenosine A1 receptor in rat cerebral cortical membranes | B | 4.85 | pKi | 14000 | nM | Ki | J Med Chem (1986) 29: 1305-1308 [PMID:3806581] |
ChEMBL | Binding affinity to A1 adenosine receptor from rat cortical membrane in presence of [3H]R-(phenylisopropyl)-adenosine | B | 4.85 | pKi | 14000 | nM | Ki | J Med Chem (1994) 37: 1526-1534 [PMID:8182711] |
ChEMBL | Displacement of [3H]CCPA from adenosine receptor A1 in rat brain cortex membranes incubated for 90 mins by radioligand competition assay | B | 4.85 | pKi | 14000 | nM | Ki | Eur J Med Chem (2020) 186: 111879-111879 [PMID:31780082] |
ChEMBL | Binding affinity for Adenosine A1 receptor from rat brain using [3H]-PIA as radioligand | B | 4.85 | pKi | 14000 | nM | Ki | J Med Chem (1990) 33: 2818-2821 [PMID:2213834] |
ChEMBL | Antagonism of binding of 1 nM [3H]cyclohexyladenosine to adenosine A1 receptors on rat cortical membranes | B | 4.85 | pKi | 14000 | nM | Ki | J Med Chem (1985) 28: 487-492 [PMID:2984420] |
ChEMBL | Binding affinity for adenosine A1 receptor from rat brain membranes using [3H]PIA as radioligand | B | 4.85 | pKi | 14000 | nM | Ki | J Med Chem (1993) 36: 2639-2644 [PMID:8410976] |
ChEMBL | Ability to inhibit binding of [3H]R-PIA to Adenosine A1 receptor in rat brain cortical membranes | B | 4.85 | pKi | 14000 | nM | Ki | J Med Chem (1997) 40: 4396-4405 [PMID:9435909] |
ChEMBL | Inhibition of 1 nM [3H]- N6-(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat cerebral cortical membranes | B | 4.89 | pKi | 13000 | nM | Ki | J Med Chem (1989) 32: 1231-1237 [PMID:2724296] |
ChEMBL | Inhibition of (R)-N6-([3H]-phenylisopropyl) adenosine binding to adenosine A1 receptor from rat cortical membranes | B | 4.89 | pKi | 13000 | nM | Ki | J Med Chem (1992) 35: 2342-2345 [PMID:1613758] |
ChEMBL | Binding affinity towards adenosine A1 receptor in rat forebrain membranes using N6-[3H]cyclohexyladenosine | B | 5.01 | pKi | 9700 | nM | Ki | J Med Chem (1992) 35: 3066-3075 [PMID:1501234] |
ChEMBL | Displacement of [3H]CPX from adenosine A1 receptor of rat brain cortical membrane | B | 5.04 | pKi | 9200 | nM | Ki | J Med Chem (1991) 34: 1202-1206 [PMID:2002461] |
GtoPdb | - | - | 5.06 | pKi | 8740 | nM | Ki |
Drug Dev Res (1999) : 45-53; J Med Chem (1993) 36: 3341-9 [PMID:8230124] |
ChEMBL | Inhibition of 1 nM [3H]- N6 -(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat fat cell membrane | B | 5.06 | pKi | 8700 | nM | Ki | J Med Chem (1989) 32: 1231-1237 [PMID:2724296] |
ChEMBL | Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligand | B | 5.07 | pKi | 8500 | nM | Ki | J Med Chem (1992) 35: 407-422 [PMID:1738138] |
ChEMBL | Inhibition of [3H]CHA binding to Adenosine A1 receptor in rat brain membranes | B | 5.07 | pKi | 8500 | nM | Ki | J Med Chem (1990) 33: 1708-1713 [PMID:2342066] |
ChEMBL | Inhibition of rat recombinant adenosine A1 receptor | B | 5.07 | pKi | 8500 | nM | Ki | J Med Chem (2014) 57: 3623-3650 [PMID:24164628] |
ChEMBL | Binding affinity against Adenosine A1 receptor in rat brain membrane, using [3H]N6-cyclohexyladenosine as the radioligand | B | 5.07 | pKi | 8500 | nM | Ki | J Med Chem (1989) 32: 2247-2254 [PMID:2795597] |
ChEMBL | Binding affinity to rat adenosine A1 receptor | B | 5.07 | pKi | 8500 | nM | Ki | J Med Chem (2009) 52: 3994-4006 [PMID:19569717] |
ChEMBL | Displacement of [3H]PIA from adenosine A1 receptors of rat brain membrane | B | 5.07 | pKi | 8500 | nM | Ki | J Med Chem (1994) 37: 3373-3382 [PMID:7932565] |
ChEMBL | Tested for binding affinity against Adenosine A1 receptor from rat forebrain membranes, using N6-[3H]- cyclohexyladenosine as radioligand | B | 5.07 | pKi | 8470 | nM | Ki | J Med Chem (1993) 36: 2508-2518 [PMID:8355252] |
ChEMBL | Binding affinity towards adenosine A1 receptor in rat whole brain membranes using N6-[3H]cyclohexyladenosine | B | 5.07 | pKi | 8470 | nM | Ki | J Med Chem (1992) 35: 3066-3075 [PMID:1501234] |
ChEMBL | Binding affinity against Adenosine A1 receptor using N6-[3H]-cyclohexyladenosinene in rat whole brain membranes | B | 5.07 | pKi | 8470 | nM | Ki | J Med Chem (1992) 35: 924-930 [PMID:1548682] |
ChEMBL | Inhibition of binding of 1 nM [3H]N-6-(phenylisopropyl)adenosine to adenosine A1 receptor in rat cortical membranes | B | 5.07 | pKi | 8470 | nM | Ki | J Med Chem (1989) 32: 1873-1879 [PMID:2754711] |
ChEMBL | Inhibition of N6-[3H]cyclohexyladenosine binding to adenosine A1 receptor from whole brain membranes | B | 5.07 | pKi | 8470 | nM | Ki | J Med Chem (1992) 35: 2342-2345 [PMID:1613758] |
ChEMBL | In vitro binding affinity to Adenosine A1 receptor of rat cerebral cortical membranes using 1 nM [3H]PIA | B | 5.13 | pKi | 7400 | nM | Ki | J Med Chem (1988) 31: 2034-2039 [PMID:3172141] |
ChEMBL | Binding affinity of specific [3H]R-PIA binding to rat Adenosine A1 receptor in HEK293 cells | B | 5.16 | pKi | 6920 | nM | Ki | J Med Chem (2002) 45: 2131-2138 [PMID:12014951] |
ChEMBL | Inhibition of [3H]-CHA binding to rat brain membrane Adenosine A1 receptor | B | 6.15 | pKi | 700 | nM | Ki | J Med Chem (1990) 33: 3127-3130 [PMID:2258897] |
ChEMBL | Antagonism of adenosine A1 receptor assessed from the ability to inhibit binding of [3H]cyclohexyladenosine to rat cerebral cortical membranes | B | 4.55 | pIC50 | 28000 | nM | IC50 | J Med Chem (1984) 27: 1364-1367 [PMID:6090665] |
ChEMBL | Binding affinity against adenosine A1 receptor in rat brain membrane preparations using N6-[3H]cyclohexyladenosine as a radioligand | B | 4.7 | pIC50 | 20000 | nM | IC50 | J Med Chem (1987) 30: 91-96 [PMID:3806606] |
ChEMBL | Inhibition of adenosine binding to A1 receptor of rat brain homogenates | B | 4.72 | pIC50 | 19000 | nM | IC50 | J Med Chem (1994) 37: 476-485 [PMID:8120866] |
ChEMBL | Inhibition of binding towards adenosine A1 receptor using [3H]N-cyclohexyladenosine ([3H]CHA) in rat whole brain membranes. | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (1988) 31: 1014-1020 [PMID:3361572] |
Adenosine A1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2304404] [UniProtKB: P47745] | ||||||||
ChEMBL | Binding affinity against adenosine A1 receptor from guinea pig forebrain membranes, using N6-[3H]cyclohexyladenosine as radioligand. | B | 4.64 | pKi | 23000 | nM | Ki | J Med Chem (1992) 35: 2342-2345 [PMID:1613758] |
ChEMBL | Inhibition of N6-[3H]cyclohexyladenosine binding to guinea pig forebrain membrane Adenosine A1 receptor | B | 4.64 | pKi | 23000 | nM | Ki | J Med Chem (1992) 35: 924-930 [PMID:1548682] |
ChEMBL | Binding affinity against Adenosine A1 receptor from guinea pig forebrain membranes by N6-[3H]- cyclohexyladenosine displacement. | B | 4.64 | pKi | 23000 | nM | Ki | J Med Chem (1993) 36: 2508-2518 [PMID:8355252] |
ChEMBL | Binding affinity against adenosine A1 receptor in guinea pig forebrain membranes using N6-[3H]cyclohexyladenosine as radioligand | B | 4.64 | pKi | 23000 | nM | Ki | J Med Chem (1992) 35: 3066-3075 [PMID:1501234] |
ChEMBL | Inhibition of [3H]cyclohexyladenosine binding to guinea pig forebrain membranes Adenosine A1 receptor | B | 4.64 | pKi | 23000 | nM | Ki | J Med Chem (1991) 34: 466-469 [PMID:1992150] |
ChEMBL | Binding affinity against Adenosine A1 receptor using N6-[3H]cyclohexyladenosine in guinea pig membranes | B | 4.89 | pKi | 13000 | nM | Ki | J Med Chem (1992) 35: 924-930 [PMID:1548682] |
ChEMBL | Affinity against adenosine A1 receptor in the brain membranes by the displacement of [3H]CPX. | B | 5.01 | pKi | 9800 | nM | Ki | J Med Chem (1992) 35: 4039-4044 [PMID:1331453] |
ChEMBL | Binding affinity against adenosine A1 receptor of cerebral cortex using [3H]CPX as a radioligand | B | 5.01 | pKi | 9800 | nM | Ki | J Med Chem (1993) 36: 1380-1386 [PMID:8496906] |
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
ChEMBL | Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay | B | 5.44 | pKd | 3630 | nM | Kd | ACS Med Chem Lett (2022) 13: 1172-1181 [PMID:35859869] |
ChEMBL | Displacement of [3H]ZM241385 from stabilized human adenosine receptor A2a expressed in HEK293 cells followed by receptor capturing on Biocore chips by SPR method | B | 5.5 | pKd | 3162.28 | nM | Kd | J Med Chem (2011) 54: 4312-4323 [PMID:21661720] |
ChEMBL | The A2A-StaR2 receptor has been purified from membranes in n-decyl-beta-D-maltoside as detergent. Then it has been reconstituted into rHDLs membrane discs.Ligands were prepared over a five-fold concentration series and injected in either a multi- or a single-cycle format depending on the kinetic parameters of the ligand. The actual concentrations as well as contact and dissociation times varied between the ligands depended on the kinetics and affinity of the interaction. The data were fitted to a 1:1 interaction model using the kinetics evaluation software from Biacore. A minimum of three measurements were recorded for each interaction. | B | 5.78 | pKd | 1642.33 | nM | Kd | K4DD drug target binding kinetics data |
ChEMBL | Affinity to A2 adenosine receptor was measured by the displacement of [3H]-CGS- 21680 in bovine brain striatal membrane | B | 4.6 | pKi | 25000 | nM | Ki | J Med Chem (1994) 37: 2970-2975 [PMID:8071944] |
ChEMBL | Displacement of [3H]-CGS- 21680 from adenosine A2A receptor in bovine striatal membranes. | B | 4.68 | pKi | 21000 | nM | Ki | J Med Chem (2000) 43: 3118-3124 [PMID:10956220] |
ChEMBL | Displacement of [3H]CGS 21680 from adenosine A2A receptor in bovine striatal membranes | B | 4.68 | pKi | 21000 | nM | Ki | J Med Chem (2006) 49: 3916-3925 [PMID:16789747] |
ChEMBL | Displacement of [3H]CGS 21680 from adenosine A2A receptor in bovine striatal membranes | B | 4.68 | pKi | 21000 | nM | Ki | J Med Chem (2005) 48: 7932-7945 [PMID:16335918] |
ChEMBL | Displacement of [3H]-CGS- 21680 from adenosine A2a receptor of bovine striatal membranes | B | 4.68 | pKi | 21000 | nM | Ki | J Med Chem (2004) 47: 3580-3590 [PMID:15214785] |
ChEMBL | Displacement of [3H]ZM241385 from human recombinant adenosine A2A receptor expressed in in human HeLa cell membrane | B | 4.73 | pKi | 18500 | nM | Ki | Bioorg Med Chem (2010) 18: 2081-2088 [PMID:20202853] |
ChEMBL | Displacement of [3H]ZM241385 from stabilized human adenosine receptor A2a expressed in HEK293 cells followed by receptor capturing on Biocore chips by SPR method | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2011) 54: 4312-4323 [PMID:21661720] |
ChEMBL | Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cells | B | 5.1 | pKi | 7900 | nM | Ki | J Med Chem (2006) 49: 3916-3925 [PMID:16789747] |
ChEMBL | Displacement of [3H]NECA from cloned human adenosine A2A receptor expressed in CHO cells | B | 5.1 | pKi | 7900 | nM | Ki | J Med Chem (2005) 48: 7932-7945 [PMID:16335918] |
ChEMBL | Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cells | B | 5.1 | pKi | 7900 | nM | Ki | J Med Chem (2007) 50: 4061-4074 [PMID:17665891] |
ChEMBL | Displacement of [3H]NECA from human cloned adenosine A2A receptor expressed in CHO cells | B | 5.1 | pKi | 7900 | nM | Ki | J Med Chem (2009) 52: 2407-2419 [PMID:19301821] |
ChEMBL | Displacement of [125I]NECA from human cloned adenosine A2A receptor expressed in CHO cells | B | 5.1 | pKi | 7900 | nM | Ki | Bioorg Med Chem (2008) 16: 6086-6102 [PMID:18468446] |
ChEMBL | DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) | B | 5.17 | pKi | 6741 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | Binding affinity to human adenosine A2A receptor | B | 5.17 | pKi | 6700 | nM | Ki | Bioorg Med Chem (2010) 18: 2195-2203 [PMID:20188574] |
ChEMBL | Displacement of [3H]ZM-241385 from human adenosine A2a receptor expressed in HEK cells | B | 5.17 | pKi | 6700 | nM | Ki | J Med Chem (2006) 49: 3682-3692 [PMID:16759111] |
ChEMBL | Binding affinity to human adenosine A2A receptor | B | 5.17 | pKi | 6700 | nM | Ki | Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167] |
ChEMBL | Binding affinity to human adenosine A2A receptor | B | 5.38 | pKi | 4200 | nM | Ki | J Med Chem (2009) 52: 3994-4006 [PMID:19569717] |
ChEMBL | Competitive binding affinity to human adenosine A2A receptor expressed in HEK293 cells after 60 mins by fluorescence polarization assay in presence of MRS5346 | B | 5.69 | pKi | 2030 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 26-36 [PMID:23200243] |
ChEMBL | Antagonist activity at adenosine A2A receptor (unknown origin) | F | 5.77 | pKi | 1710 | nM | Ki | Eur J Med Chem (2022) 227: 113907-113907 [PMID:34695776] |
ChEMBL | Displacement of [3H]NECA from human adenosine receptor A2A expressed in CHO cell membranes by radioligand competition assay | B | 5.77 | pKi | 1710 | nM | Ki | J Med Chem (2020) 63: 2577-2587 [PMID:31738058] |
ChEMBL | Displacement of [3H]MSX2 from human adenosine receptor A2A expressed in HEK293 cell membranes incubated for 30 mins by radioligand competition assay | B | 5.77 | pKi | 1710 | nM | Ki | Eur J Med Chem (2020) 186: 111879-111879 [PMID:31780082] |
ChEMBL | Displacement of [3H]NECA from human A2A adenosine receptor expressed in CHO cells | B | 5.77 | pKi | 1710 | nM | Ki | Medchemcomm (2016) 7: 845-852 |
ChEMBL | Binding affinity to human adenosine A2A receptor by radioligand displacement assay | B | 5.77 | pKi | 1710 | nM | Ki | Medchemcomm (2018) 9: 951-962 [PMID:30108984] |
ChEMBL | Displacement of [3H]CGS21680 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting analysis | B | 5.77 | pKi | 1700 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 26-36 [PMID:23200243] |
GtoPdb | - | - | 5.8 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 1-9 [PMID:9459566]; Biochem Pharmacol (2005) 70: 1601-12 [PMID:16219300]; Br J Pharmacol (1997) 121: 353-60 [PMID:9179373]; Drug Dev Res (1999) : 45-53 |
ChEMBL | Binding affinity for adenosine A2a receptor by using as [3H]ZM-241385 radioligand in membranes from HEK-A2A cells | B | 9.22 | pKi | 0.6 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 609-612 [PMID:15664822] |
ChEMBL | DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) | B | 4.92 | pIC50 | 12007 | nM | IC50 | DrugMatrix in vitro pharmacology data |
ChEMBL | Relaxant activity on the spontaneous tone of isolated guinea pig tracheal ring chains. | F | 4.55 | pEC50 | 28200 | nM | EC50 | J Med Chem (1992) 35: 4039-4044 [PMID:1331453] |
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] | ||||||||
ChEMBL | Binding affinity to rat adenosine A2A receptor | B | 4.6 | pKi | 25000 | nM | Ki | J Med Chem (2009) 52: 3994-4006 [PMID:19569717] |
ChEMBL | Inhibition of rat recombinant adenosine receptor A2a | B | 4.6 | pKi | 25000 | nM | Ki | J Med Chem (2014) 57: 3623-3650 [PMID:24164628] |
ChEMBL | Displacement of [3H]-CGS- 21680 from adenosine A2a receptors of rat striatal membrane | B | 4.6 | pKi | 25000 | nM | Ki | J Med Chem (1994) 37: 3373-3382 [PMID:7932565] |
ChEMBL | Displacement of [3H]MSX2 from adenosine receptor A2A in rat brain striatum membranes incubated for 30 mins by radioligand competition assay | B | 4.66 | pKi | 22000 | nM | Ki | Eur J Med Chem (2020) 186: 111879-111879 [PMID:31780082] |
ChEMBL | Displacement of [3H]CGS21680 from adenosine A2A receptor in rat brain striatal membrane | B | 4.66 | pKi | 22000 | nM | Ki | J Nat Prod (1998) 61: 301-305 [PMID:9514015] |
ChEMBL | Binding affinity to rat adenosine A2A receptor | B | 4.66 | pKi | 22000 | nM | Ki | Bioorg Med Chem (2010) 18: 2195-2203 [PMID:20188574] |
ChEMBL | Binding affinity to rat adenosine A2A receptor | B | 4.66 | pKi | 22000 | nM | Ki | Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167] |
GtoPdb | - | - | 4.66 | pKi | 22000 | nM | Ki |
Drug Dev Res (1999) : 45-53; J Med Chem (1993) 36: 3341-9 [PMID:8230124] |
ChEMBL | Ability to inhibit binding of [3H]NECA to Adenosine A2A receptor in rat brain striatal membranes | B | 4.72 | pKi | 19000 | nM | Ki | J Med Chem (1997) 40: 4396-4405 [PMID:9435909] |
ChEMBL | Ability to inhibit binding of [3H]-CGS- 21680 to adenosine A2A receptor in rat brain striatal membranes. | B | 5.03 | pKi | 9400 | nM | Ki | J Med Chem (1997) 40: 4396-4405 [PMID:9435909] |
ChEMBL | Binding affinity for adenosine A2A receptor from rat brain membranes using [3H]CGS-21680 | B | 5.1 | pKi | 8000 | nM | Ki | J Med Chem (1993) 36: 2639-2644 [PMID:8410976] |
ChEMBL | Binding affinity at rat Adenosine A2A receptor by [3H]-CGS- 21680 displacement. | B | 5.17 | pKi | 6700 | nM | Ki | J Med Chem (2002) 45: 2131-2138 [PMID:12014951] |
Adenosine A2a receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2605] [UniProtKB: P46616] | ||||||||
ChEMBL | Affinity against adenosine A2 receptor in the brain membranes measured by the displacement of [3H]-CPX | B | 4.78 | pKi | 16600 | nM | Ki | J Med Chem (1992) 35: 4039-4044 [PMID:1331453] |
ChEMBL | Compound was evaluated for its ability to antagonise cyclic [3H]AMP accumulation in [3H]adenine-labeled guinea pig cerebral cortical slices. | F | 4.85 | pKi | 14000 | nM | Ki | J Med Chem (1986) 29: 1305-1308 [PMID:3806581] |
ChEMBL | Antagonism of cyclic [3H]AMP accumulation in guinea pig cerebral cortical slices (elicited by 15 uM 2-chloroadenosine at adenosine A2 receptor) | F | 4.85 | pKi | 14000 | nM | Ki | J Med Chem (1985) 28: 487-492 [PMID:2984420] |
ChEMBL | Antagonist binding of N6-cyclohexyl-[3H]-adenosine to guinea pig brain | B | 4.89 | pKi | 13000 | nM | Ki | J Med Chem (1982) 25: 197-207 [PMID:6279840] |
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
GtoPdb | - | - | 5.04 | pKi | 9070 | nM | Ki |
Biochem Pharmacol (2005) 70: 1601-12 [PMID:16219300]; Biochem Pharmacol (2001) 62: 1163-73 [PMID:11705449]; J Med Chem (2002) 45: 2131-8 [PMID:12014951]; Purinergic Signal (2006) 2: 559-71 [PMID:18404493] |
ChEMBL | Antagonist activity at adenosine A2B receptor (unknown origin) | F | 5.04 | pKi | 9070 | nM | Ki | Eur J Med Chem (2022) 227: 113907-113907 [PMID:34695776] |
ChEMBL | Displacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrs | B | 5.04 | pKi | 9070 | nM | Ki | J Med Chem (2016) 59: 1967-1983 [PMID:26824742] |
ChEMBL | Binding affinity to human adenosine A2B receptor by radioligand displacement assay | B | 5.04 | pKi | 9070 | nM | Ki | Medchemcomm (2018) 9: 951-962 [PMID:30108984] |
ChEMBL | Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay | B | 5.04 | pKi | 9070 | nM | Ki | Eur J Med Chem (2020) 186: 111879-111879 [PMID:31780082] |
ChEMBL | Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand | B | 5.04 | pKi | 9070 | nM | Ki | J Med Chem (2002) 45: 2131-2138 [PMID:12014951] |
ChEMBL | Antagonist activity against human Adenosine A2b receptor | F | 5.04 | pKi | 9070 | nM | Ki | J Med Chem (2005) 48: 6813-6820 [PMID:16250640] |
ChEMBL | Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells | B | 5.04 | pKi | 9070 | nM | Ki | J Med Chem (2006) 49: 3682-3692 [PMID:16759111] |
ChEMBL | Binding affinity to human adenosine A2B receptor | B | 5.04 | pKi | 9070 | nM | Ki | Bioorg Med Chem (2010) 18: 2195-2203 [PMID:20188574] |
ChEMBL | Antagonist activity against human adenosine A2B receptor | F | 5.04 | pKi | 9070 | nM | Ki | Eur J Med Chem (2010) 45: 3459-3471 [PMID:20537438] |
ChEMBL | Binding affinity to human adenosine A2B receptor | B | 5.04 | pKi | 9070 | nM | Ki | Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167] |
ChEMBL | Displacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assay | B | 5.05 | pKi | 9000 | nM | Ki | Eur J Med Chem (2017) 127: 986-996 [PMID:27842891] |
ChEMBL | Binding affinity to human adenosine A2B receptor | B | 5.11 | pKi | 7850 | nM | Ki | J Med Chem (2009) 52: 3994-4006 [PMID:19569717] |
ChEMBL | Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 radioligand in membranes from HEK-A2B cells | B | 5.15 | pKi | 7059 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 609-612 [PMID:15664822] |
ChEMBL | Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membrane | B | 5.57 | pKi | 2700 | nM | Ki | Bioorg Med Chem (2010) 18: 2081-2088 [PMID:20202853] |
A2B receptor in Mouse [GtoPdb: 20] [UniProtKB: Q60614] | ||||||||
GtoPdb | - | - | 5.25 | pKi | 5630 | nM | Ki | J Pharmacol Exp Ther (2009) 329: 2-13 [PMID:19141710] |
A2B receptor/Adenosine A2b receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2592] [GtoPdb: 20] [UniProtKB: P29276] | ||||||||
ChEMBL | Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells | B | 4.82 | pKi | 15100 | nM | Ki | J Med Chem (2002) 45: 2131-2138 [PMID:12014951] |
ChEMBL | Binding affinity to rat adenosine A2B receptor | B | 4.82 | pKi | 15100 | nM | Ki | J Med Chem (2009) 52: 3994-4006 [PMID:19569717] |
ChEMBL | Binding affinity to rat adenosine A2B receptor | B | 4.82 | pKi | 15100 | nM | Ki | Bioorg Med Chem (2010) 18: 2195-2203 [PMID:20188574] |
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
ChEMBL | Displacement of [3H]HEMADO from human adenosine receptor A3 expressed in CHO cell membranes by radioligand competition assay | B | 4.06 | pKi | 86400 | nM | Ki | J Med Chem (2020) 63: 2577-2587 [PMID:31738058] |
ChEMBL | Binding affinity against human adenosine A3 receptor expressed in CHO cells by [125I]AB-MECA displacement. | B | 4.07 | pKi | 86000 | nM | Ki | J Med Chem (2004) 47: 3580-3590 [PMID:15214785] |
ChEMBL | Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells. | B | 4.07 | pKi | 86000 | nM | Ki | J Med Chem (2000) 43: 3118-3124 [PMID:10956220] |
ChEMBL | Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells | B | 4.07 | pKi | 86000 | nM | Ki | J Med Chem (2005) 48: 7932-7945 [PMID:16335918] |
ChEMBL | Binding affinity towards human adenosine A3 receptor expressed in HEK293 cells using [125I]AB-MECA at 1 uM | B | 4.07 | pKi | 86000 | nM | Ki | J Med Chem (2000) 43: 1158-1164 [PMID:10737748] |
ChEMBL | Displacement of [125I]AB-MECA from human cloned adenosine A3 receptor expressed in CHO cells | B | 4.07 | pKi | 86000 | nM | Ki | Bioorg Med Chem (2008) 16: 6086-6102 [PMID:18468446] |
ChEMBL | Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells | B | 4.07 | pKi | 86000 | nM | Ki | J Med Chem (2006) 49: 3916-3925 [PMID:16789747] |
ChEMBL | Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells | B | 4.07 | pKi | 86000 | nM | Ki | J Med Chem (2007) 50: 4061-4074 [PMID:17665891] |
ChEMBL | Displacement of [125I]AB-MECA from human cloned adenosine A3 receptor expressed in CHO cells | B | 4.07 | pKi | 86000 | nM | Ki | J Med Chem (2009) 52: 2407-2419 [PMID:19301821] |
ChEMBL | Displacement of [3H]NECA from human recombinant adenosine A3 receptor expressed in human HeLa cell membrane | B | 4.07 | pKi | 85100 | nM | Ki | Bioorg Med Chem (2010) 18: 2081-2088 [PMID:20202853] |
ChEMBL | Binding affinity to human adenosine A3 receptor | B | 4.28 | pKi | 52300 | nM | Ki | J Med Chem (2009) 52: 3994-4006 [PMID:19569717] |
ChEMBL | Competitive binding affinity to human adenosine A3 receptor expressed in CHO cells after 90 mins by flow cytometric analysis in presence of MRS5449 | B | 4.53 | pKi | 29400 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 26-36 [PMID:23200243] |
GtoPdb | - | - | 4.65 | pKi | 22300 | nM | Ki |
Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 1-9 [PMID:9459566]; Drug Dev Res (1999) : 45-53 |
ChEMBL | Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells | B | 4.65 | pKi | 22300 | nM | Ki | J Med Chem (2006) 49: 3682-3692 [PMID:16759111] |
ChEMBL | Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in CHO cells after 90 mins by gamma counting analysis | B | 4.65 | pKi | 22300 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 26-36 [PMID:23200243] |
ChEMBL | Binding affinity to human adenosine A3 receptor | B | 4.65 | pKi | 22300 | nM | Ki | Bioorg Med Chem (2013) 21: 7435-7452 [PMID:24139167] |
ChEMBL | Binding affinity to human adenosine A3 receptor by radioligand displacement assay | B | 4.65 | pKi | 22300 | nM | Ki | Medchemcomm (2018) 9: 951-962 [PMID:30108984] |
ChEMBL | Antagonist activity at adenosine A3 receptor (unknown origin) | F | 4.65 | pKi | 22300 | nM | Ki | Eur J Med Chem (2022) 227: 113907-113907 [PMID:34695776] |
ChEMBL | Binding affinity to human adenosine A3 receptor | B | 4.65 | pKi | 22300 | nM | Ki | Bioorg Med Chem (2010) 18: 2195-2203 [PMID:20188574] |
ChEMBL | Displacement of [3H]PSB-11 from human adenosine receptor A3 expressed in CHO cell membranes incubated for 60 mins by radioligand competition assay | B | 4.65 | pKi | 22300 | nM | Ki | Eur J Med Chem (2020) 186: 111879-111879 [PMID:31780082] |
ChEMBL | Binding affinity for adenosine A3 receptor by displacement of specific binding of [125I]AB-MECA in membranes from CHO-A3 cells | B | 7.85 | pKi | 14 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 609-612 [PMID:15664822] |
A3 receptor/Adenosine A3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647] | ||||||||
ChEMBL | Binding affinity to rat adenosine A3 receptor | B | 4 | pKi | 100000 | nM | Ki | J Med Chem (2009) 52: 3994-4006 [PMID:19569717] |
ChEMBL | Displacement of [3H]NECA from rat adenosine receptor A3 expressed in CHO cell membranes incubated for 60 mins by radioligand competition assay | B | 4 | pKi | >100000 | nM | Ki | Eur J Med Chem (2020) 186: 111879-111879 [PMID:31780082] |
GtoPdb | - | - | 4.07 | pKi | 85000 | nM | Ki |
Mol Pharmacol (1994) 45: 1101-11 [PMID:8022403]; Bioconjug Chem (1995) 6: 255-63 [PMID:7632796] |
ChEMBL | Binding affinity to rat adenosine A3 receptor | B | 4.07 | pKi | 85000 | nM | Ki | Bioorg Med Chem (2010) 18: 2195-2203 [PMID:20188574] |
Alkaline phosphatase, tissue-nonspecific isozyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5979] [UniProtKB: P05186] | ||||||||
ChEMBL | Inhibition of TNSALP | B | 4.09 | pKi | 82000 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 222-225 [PMID:19038545] |
ChEMBL | Inhibition of human TNAP expressed in COS7 cells preincubated for 5 to 7 mins followed by CDP-star substrate addition measured after 15 to 20 mins by luminescence assay | B | 4 | pIC50 | >100000 | nM | IC50 | Eur J Med Chem (2018) 144: 116-127 [PMID:29268128] |
ChEMBL | Inhibition of TNAP by analogous luminescence assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | Bioorg Med Chem (2010) 18: 573-579 [PMID:20031422] |
CYP3A4/Cytochrome P450 3A4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL340] [GtoPdb: 1337] [UniProtKB: P08684] | ||||||||
ChEMBL | null: A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. CYP3A4A is thought to be one of the primary CYP isoforms responsible for retinoic acid metabolism in the skin. Three benchmark agents, liarozole, climbazole, and ketoconazole, were assessed for CYP3A4 inhibition to confirm that the inhibition activity (the IC50 for CYP3A4 inhibition) measured by the assay corresponds to the activity reported by the published literature. The results show that the substituted azole compounds having the specific structure set forth herein are CYP inhibitors, and thus function as RAMBAs. | B | 5 | pIC50 | >10000 | nM | IC50 | US-9138393-B2. Cosmetic compositions containing substituted azole and methods for improving the appearance of aging skin (2015) |
ChEMBL | In vitro CYP3A4 Inhibition Assay: Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute to the elimination of ATRA by catalyzing its 4-hydroxylation in the mammalian liver and skin, including that of humans as well as swine. Applicant evaluated the potential RAMBA activity of several azoles using pig liver microsomes, a rich source of CYP activity, comprising many different CYP 450 isoforms. Therefore, this approach, while a reasonable way to assess CYP inhibitors with broad activities may or may not be the best way to discover RAMBAs with selectivity for the skin, which has a much more narrow complement of CYP expression. As understanding in this area has progressed, a more specific CYP inhibition assay can be used to provide better predictivity of activity in human skin. Nevertheless, this assay may still be used as a general predictor of overall CYP activity. | B | 5 | pIC50 | >10000 | nM | IC50 | US-9144538-B2. Cosmetic compositions containing substituted azole and methods for alleviating the signs of photoaged skin (2015) |
Intestinal alkaline phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5573] [UniProtKB: P09923] | ||||||||
ChEMBL | Inhibition of IAP by analogous luminescence assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | Bioorg Med Chem (2010) 18: 573-579 [PMID:20031422] |
Phosphodiesterase 3B in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5129] [UniProtKB: E1BN64] | ||||||||
ChEMBL | Inhibition of bovine heart phosphodiesterase | B | 4.11 | pKi | 77000 | nM | Ki | J Med Chem (1982) 25: 420-426 [PMID:6279846] |
ChEMBL | Inhibition of bovine heart phosphodiesterase | B | 4.05 | pIC50 | 90000 | nM | IC50 | J Med Chem (1982) 25: 420-426 [PMID:6279846] |
Phospholipase A-2-activating protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6114] [UniProtKB: Q9Y263] | ||||||||
ChEMBL | Inhibition of PLAP by analogous luminescence assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | Bioorg Med Chem (2010) 18: 573-579 [PMID:20031422] |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329] | ||||||||
ChEMBL | Inhibition of PI3Kdelta (unknown origin) | B | 4.12 | pIC50 | 75000 | nM | IC50 | Medchemcomm (2012) 3: 1337-1355 |
Transmembrane domain-containing protein TMIGD3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3712907] [UniProtKB: P0DMS9] | ||||||||
ChEMBL | Displacement of [3H]HEMADO from human A3 adenosine receptor expressed in CHO cells | B | 4.06 | pKi | 86400 | nM | Ki | Medchemcomm (2016) 7: 845-852 |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]