ChEMBL ligand: CHEMBL986 (Arovit, Nepalm, NSC-122759, Retinol, Retinol (vit a), Ro-a-vit, Vitamin a, Vitamin a 1)
synuclein alpha/Alpha-synuclein in Human [ChEMBL: CHEMBL6152] [GtoPdb: 3285] [UniProtKB: P37840] There should be some charts here, you may need to enable JavaScript!
Amyloid-beta precursor protein in Human [ChEMBL: CHEMBL2487] [UniProtKB: P05067] There should be some charts here, you may need to enable JavaScript!
Beta-lactoglobulin in Bovine [ChEMBL: CHEMBL1075053] [UniProtKB: P02754] There should be some charts here, you may need to enable JavaScript!
retinol binding protein 4/Retinol-binding protein 4 in Human [ChEMBL: CHEMBL3100] [GtoPdb: 2549] [UniProtKB: P02753] There should be some charts here, you may need to enable JavaScript!
Testicular receptor 4 in Human [GtoPdb: 614] [UniProtKB: P49116] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
synuclein alpha/Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [GtoPdb: 3285] [UniProtKB: P37840]
ChEMBL	Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay	B	6.72	pIC50	190	nM	IC50	Eur J Med Chem (2019) 167: 10-36 [PMID:30743095]
Amyloid-beta precursor protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL	Inhibition of amyloid beta (1 to 40) (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay	B	6.74	pIC50	180	nM	IC50	Eur J Med Chem (2019) 167: 10-36 [PMID:30743095]
Beta-lactoglobulin in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075053] [UniProtKB: P02754]
ChEMBL	Binding affinity to bovine beta-lactoglobulins by fluorescence spectroscopy	B	7.44	pKd	36	nM	Kd	J Med Chem (2010) 53: 514-518 [PMID:19938842]
retinol binding protein 4/Retinol-binding protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3100] [GtoPdb: 2549] [UniProtKB: P02753]
ChEMBL	Binding affinity to His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as apparent dissociation constant after 5 mins by fluorescence spectrophotometric analysis	B	6.74	pKd	182	nM	Kd	J Med Chem (2011) 54: 4378-4387 [PMID:21591606]
ChEMBL	Binding affinity to N-terminal His-tagged human recombinant RBP4 (19 to 201 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant by ELISA method	B	8.08	pKi	8.3	nM	Ki	J Med Chem (2024) 67: 5144-5167 [PMID:38525852]
Testicular receptor 4 in Human [GtoPdb: 614] [UniProtKB: P49116]
GtoPdb	-	-	4.71	pEC50	19400	nM	EC50	J Biol Chem (2011) 286: 2877-85 [PMID:21068381]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]