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retinol binding protein 4

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Target id: 2549

Nomenclature: retinol binding protein 4

Family: Fatty acid-binding proteins

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 201 10q23.33 RBP4 retinol binding protein 4
Mouse - 201 19 32.75 cM Rbp4 retinol binding protein 4, plasma
Rat - 201 1q53 Rbp4 retinol binding protein 4
Previous and Unofficial Names Click here for help
PRBP | RBPA | retinol binding protein 4, plasma
Database Links Click here for help
Alphafold P02753 (Hs), Q00724 (Mm), P04916 (Rn)
CATH/Gene3D 2.40.128.20
ChEMBL Target CHEMBL3100 (Hs)
Ensembl Gene ENSG00000138207 (Hs), ENSMUSG00000024990 (Mm), ENSRNOG00000015518 (Rn)
Entrez Gene 5950 (Hs), 19662 (Mm), 25703 (Rn)
Human Protein Atlas ENSG00000138207 (Hs)
KEGG Gene hsa:5950 (Hs), mmu:19662 (Mm), rno:25703 (Rn)
OMIM 180250 (Hs)
Pharos P02753 (Hs)
RefSeq Nucleotide NM_006744 (Hs), NM_001159487 (Mm), NM_011255 (Mm), NM_013162 (Rn)
RefSeq Protein NP_006735 (Hs), NP_001152959 (Mm), NP_035385 (Mm), NP_037294 (Rn)
SynPHARM 82796 (in complex with A1120)
UniProtKB P02753 (Hs), Q00724 (Mm), P04916 (Rn)
Wikipedia RBP4 (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of retinol-binding protein 4 (RBP4) in complex with non-retinoid ligand.
PDB Id:  3FMZ
Ligand:  A1120
Resolution:  2.9Å
Species:  Human
References:  2

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
tinlarebant Small molecule or natural product Hs Inhibition 8.4 pIC50 1
⤷ pIC50 8.4 (IC50 4.45x10-9 M) [1]
Description: Determined in a SPR binding assay
A1120 Small molecule or natural product Ligand has a PDB structure Hs Inhibition 7.8 pIC50 3
⤷ pIC50 7.8 (IC50 1.4x10-8 M) [3]
Description: Measured using a FRET assay to monitor human RBP4–transthyretin interaction.

References

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1. Cioffi C, Johnson G, Allikmets R, Chen P, Conlon M, Zhu L. (2015) Substituted 4-phenylpiperidines, their preparaiton and use. Patent number: WO2015168286A1. Assignee: Trustees Of Columbia University In The City Of New York, Petrukhin K, Freeman E. Priority date: 29/04/2015. Publication date: 05/11/2015.

2. Motani A, Wang Z, Conn M, Siegler K, Zhang Y, Liu Q, Johnstone S, Xu H, Thibault S, Wang Y et al.. (2009) Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. J Biol Chem, 284 (12): 7673-80. [PMID:19147488]

3. Wang Y, Connors R, Fan P, Wang X, Wang Z, Liu J, Kayser F, Medina JC, Johnstone S, Xu H et al.. (2014) Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4. Bioorg Med Chem Lett, 24 (13): 2885-91. [PMID:24835984]

How to cite this page

Fatty acid-binding proteins: retinol binding protein 4. Last modified on 29/10/2025. Accessed on 12/12/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2549.