ChEMBL ligand: CHEMBL419792 (Pnu-95666, PNU-95666E, Sumanirol, Sumanirole)
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] There should be some charts here, you may need to enable JavaScript!
D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL	Displacement of [3H]N-methylspiperone from human D2 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counter	B	4.79	pKi	16300	nM	Ki	J Med Chem (2016) 59: 2973-2988 [PMID:27035329]
ChEMBL	Displacement of [3H]-methylscopolamine from human dopamine D2 receptor expressed in HEK293 cell membranes incubated for 90 mins by microbeta scintillation counting analysis	B	4.79	pKi	16300	nM	Ki	J Med Chem (2021) 64: 16088-16105 [PMID:34699207]
ChEMBL	Displacement of [3H]-(R)-(+)7-OH-DPAT from human dopamine D2 receptor expressed in HEK293 cell membranes incubated for 90 mins by microbeta scintillation counting analysis	B	7.09	pKi	80.6	nM	Ki	J Med Chem (2021) 64: 16088-16105 [PMID:34699207]
ChEMBL	Displacement of [3H]-(R)-(+)-7-OH-DPAT from human dopamine D2 receptor expressed in HEK293 cell membranes after 90 mins by micro beta scintillation counting analysis	B	7.33	pKi	46.3	nM	Ki	J Med Chem (2017) 60: 2890-2907 [PMID:28300398]
ChEMBL	Displacement of [3H]7-OH-DPAT from human D2 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counter	B	7.77	pKi	17.1	nM	Ki	J Med Chem (2016) 59: 2973-2988 [PMID:27035329]
ChEMBL	Binding affinity towards Dopamine receptor D2 by displacement of [3H]U-86170.	B	8.05	pKi	9	nM	Ki	J Med Chem (1997) 40: 639-646 [PMID:9057850]
GtoPdb	-	-	8.1	pKi	9	nM	Ki	J Pharmacol Exp Ther (2005) 314: 1248-56 [PMID:15980060]
ChEMBL	Agonist activity at human dopamine D2 receptor expressed in HEK293 cells coexpressing renilla luciferase-fused Galphai1/GFP10-fused Ggamma2 by BRET assay	B	6.26	pEC50	543.3	nM	EC50	J Med Chem (2017) 60: 2890-2907 [PMID:28300398]
ChEMBL	Agonist activity at renilla luciferase-tagged human dopamine D2 receptor expressed in HEK293 cells coexpressing mVenus-fused beta-arrestin 2 assessed as induction of beta-arrestin 2 recruitment by BRET assay	B	6.3	pEC50	501.2	nM	EC50	J Med Chem (2017) 60: 2890-2907 [PMID:28300398]
ChEMBL	In vitro effective concentration tested on HEK293 cells co-transfected with human Dopamine receptor D2 using FLIPR assay	F	6.78	pEC50	165	nM	EC50	J Med Chem (2004) 47: 3853-3864 [PMID:15239663]
ChEMBL	Agonist activity at human dopamine D2 receptor expressed in HEK293 cells coexpressing renilla luciferase-fused GalphaoA/GFP10-fused Ggamma2 by BRET assay	B	7.13	pEC50	74.8	nM	EC50	J Med Chem (2017) 60: 2890-2907 [PMID:28300398]
ChEMBL	Agonist activity at recombinant human D2 receptor expressing in CHOp cells assessed as receptor mediated stimulation of mitogenesis measured as [3H]thymidine incorporation after 24 hrs by scintillation spectrometry	B	7.19	pEC50	64.7	nM	EC50	J Med Chem (2016) 59: 2973-2988 [PMID:27035329]
ChEMBL	Agonist activity at human D2 receptor transfected in HEK293T cells by BRET based G0 activation assay	B	7.22	pEC50	60.1	nM	EC50	J Med Chem (2016) 59: 2973-2988 [PMID:27035329]
ChEMBL	Agonist activity at human dopamine D2 receptor expressed in HEK293 cells assessed as cAMP inhibition by BRET assay	F	7.49	pEC50	32.2	nM	EC50	J Med Chem (2017) 60: 2890-2907 [PMID:28300398]
ChEMBL	Agonist activity at recombinant human D2 receptor expressing in CHO cells assessed as receptor mediated stimulation of mitogenesis measured as [3H]thymidine incorporation by beta plate counter	B	8.34	pEC50	4.6	nM	EC50	J Med Chem (2016) 59: 2973-2988 [PMID:27035329]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL	In vitro effective concentration tested on HEK293 cells co-transfected with ferret Dopamine receptor D2 using FLIPR assay	F	7.46	pEC50	35	nM	EC50	J Med Chem (2004) 47: 3853-3864 [PMID:15239663]
ChEMBL	In vitro effective concentration tested on HEK293 cells co-transfected with rat Dopamine receptor D2 using FLIPR assay	F	7.97	pEC50	10.8	nM	EC50	J Med Chem (2004) 47: 3853-3864 [PMID:15239663]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL	Displacement of [3H]N-methylspiperone from human D3 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counter	B	5.2	pKi	6330	nM	Ki	J Med Chem (2016) 59: 2973-2988 [PMID:27035329]
ChEMBL	Displacement of [3H]-methylscopolamine from human dopamine D3 receptor expressed in HEK293 cell membranes incubated for 90 mins by microbeta scintillation counting analysis	B	5.2	pKi	6330	nM	Ki	J Med Chem (2021) 64: 16088-16105 [PMID:34699207]
ChEMBL	Binding affinity towards Dopamine receptor D3 by displacement of [3H](+)-7-OH-DPAT.	B	5.63	pKi	2333	nM	Ki	J Med Chem (1997) 40: 639-646 [PMID:9057850]
ChEMBL	Displacement of [3H]-(R)-(+)7-OH-DPAT from human dopamine D3 receptor expressed in HEK293 cell membranes incubated for 90 mins by microbeta scintillation counting analysis	B	6.11	pKi	784	nM	Ki	J Med Chem (2021) 64: 16088-16105 [PMID:34699207]
ChEMBL	Displacement of [3H]-(R)-(+)-7-OH-DPAT from human dopamine D3 receptor expressed in HEK293 cell membranes after 90 mins by micro beta scintillation counting analysis	B	6.24	pKi	573	nM	Ki	J Med Chem (2017) 60: 2890-2907 [PMID:28300398]
ChEMBL	Displacement of [3H]7-OH-DPAT from human D3 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counter	B	6.26	pKi	546	nM	Ki	J Med Chem (2016) 59: 2973-2988 [PMID:27035329]
ChEMBL	Agonist activity at recombinant human D3 receptor expressing in CHOp cells assessed as receptor mediated stimulation of mitogenesis measured as [3H]thymidine incorporation after 24 hrs by scintillation spectrometry	B	6.17	pEC50	669	nM	EC50	J Med Chem (2016) 59: 2973-2988 [PMID:27035329]
ChEMBL	Agonist activity at human D3 receptor transfected in HEK293T cells by BRET based G0 activation assay	B	6.73	pEC50	186	nM	EC50	J Med Chem (2016) 59: 2973-2988 [PMID:27035329]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL	Binding affinity towards Serotonin 5-hydroxytryptamine 1A receptor by displacement of [3H]-(+)-8-OH-DPAT.	B	7.14	pKi	73	nM	Ki	J Med Chem (1997) 40: 639-646 [PMID:9057850]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]