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ChEMBL ligand: CHEMBL260331 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
ChEMBL | Binding affinity towards human adenosine A1 receptor expressed in CHO cells using [3H]DPCPX | B | 6.61 | pKi | 248 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 3611-3614 [PMID:15177485] |
ChEMBL | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells | B | 6.7 | pKi | 200 | nM | Ki | Bioorg Med Chem (2008) 16: 2419-2430 [PMID:18077171] |
ChEMBL | Displacement of specific [3H]DPCPX binding at human adenosine A1 receptor expressed in CHO cells | B | 6.7 | pKi | 200 | nM | Ki | J Med Chem (2004) 47: 1434-1447 [PMID:14998332] |
ChEMBL | Antagonist activity against human adenosine A1 receptor | F | 6.7 | pKi | 200 | nM | Ki | Eur J Med Chem (2010) 45: 3459-3471 [PMID:20537438] |
ChEMBL | Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in CHO cells after 120 mins by scintillation counting | B | 6.7 | pKi | 200 | nM | Ki | J Med Chem (2012) 55: 797-811 [PMID:22148859] |
ChEMBL | Binding affinity to human adenosine A1 receptor | B | 6.7 | pKi | 200 | nM | Ki | J Med Chem (2012) 55: 797-811 [PMID:22148859] |
ChEMBL | Binding affinity to human adenosine A1 receptor | B | 6.7 | pKi | 200 | nM | Ki | J Med Chem (2009) 52: 3994-4006 [PMID:19569717] |
GtoPdb | - | - | 6.7 | pKi | - | - | - |
Biochem Pharmacol (2005) 70: 1601-12 [PMID:16219300]; J Med Chem (2004) 47: 1434-47 [PMID:14998332] |
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
GtoPdb | - | - | 6 | pKi | >1000 | nM | Ki | J Med Chem (2004) 47: 1434-47 [PMID:14998332] |
ChEMBL | Binding affinity of compound for displacement of specific [3H]ZM-241385 binding at human adenosine A2A receptor expressed in CHO cells | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2004) 47: 1434-1447 [PMID:14998332] |
ChEMBL | Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in CHO cells | B | 6 | pKi | >1000 | nM | Ki | Bioorg Med Chem (2008) 16: 2419-2430 [PMID:18077171] |
ChEMBL | Binding affinity to human adenosine A2A receptor | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2009) 52: 3994-4006 [PMID:19569717] |
ChEMBL | Antagonist activity against human adenosine A2A receptor | F | 6 | pKi | >1000 | nM | Ki | Eur J Med Chem (2010) 45: 3459-3471 [PMID:20537438] |
ChEMBL | Displacement of [3H]ZM241385 from human recombinant adenosine A2A receptor expressed in CHO cells after 120 mins by scintillation counting | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2012) 55: 797-811 [PMID:22148859] |
ChEMBL | Binding affinity to human adenosine A2A receptor | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2012) 55: 797-811 [PMID:22148859] |
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
ChEMBL | Binding affinity of [3H]-MRE 2029-F20 towards human adenosine A2b receptor expressed in CHO cells | B | 8.78 | pKd | 1.65 | nM | Kd | Bioorg Med Chem Lett (2004) 14: 3611-3614 [PMID:15177485] |
ChEMBL | Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells | B | 8.26 | pKi | 5.5 | nM | Ki | J Med Chem (2004) 47: 1434-1447 [PMID:14998332] |
ChEMBL | Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors | B | 8.26 | pKi | 5.5 | nM | Ki | J Med Chem (2004) 47: 1434-1447 [PMID:14998332] |
ChEMBL | Antagonist activity against human Adenosine A2b receptor | F | 8.26 | pKi | 5.5 | nM | Ki | J Med Chem (2005) 48: 6813-6820 [PMID:16250640] |
ChEMBL | Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells | B | 8.26 | pKi | 5.5 | nM | Ki | Bioorg Med Chem (2008) 16: 2419-2430 [PMID:18077171] |
ChEMBL | Binding affinity to human adenosine A2B receptor | B | 8.26 | pKi | 5.5 | nM | Ki | J Med Chem (2009) 52: 3994-4006 [PMID:19569717] |
ChEMBL | Antagonist activity against human adenosine A2B receptor | F | 8.26 | pKi | 5.5 | nM | Ki | Eur J Med Chem (2010) 45: 3459-3471 [PMID:20537438] |
ChEMBL | Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting | B | 8.26 | pKi | 5.5 | nM | Ki | J Med Chem (2012) 55: 797-811 [PMID:22148859] |
ChEMBL | Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in CHO cells | B | 8.26 | pKi | 5.5 | nM | Ki | J Med Chem (2012) 55: 797-811 [PMID:22148859] |
ChEMBL | Displacement of [3H] DPCPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 60 mins | B | 8.26 | pKi | 5.5 | nM | Ki | J Med Chem (2016) 59: 1967-1983 [PMID:26824742] |
ChEMBL | Displacement of [3H]DPCPX from human adenosine receptor A2b expressed in HEK293 cell membranes | B | 8.26 | pKi | 5.5 | nM | Ki | Eur J Med Chem (2017) 127: 986-996 [PMID:27842891] |
GtoPdb | - | - | 8.5 | pKi | - | - | - |
Biochem Pharmacol (2005) 70: 1601-12 [PMID:16219300]; J Med Chem (2004) 47: 1434-47 [PMID:14998332] |
ChEMBL | Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor | F | 7.42 | pIC50 | 38 | nM | IC50 | J Med Chem (2004) 47: 1434-1447 [PMID:14998332] |
ChEMBL | Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting | F | 7.42 | pIC50 | 38 | nM | IC50 | J Med Chem (2012) 55: 797-811 [PMID:22148859] |
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
GtoPdb | - | - | 6 | pKi | >1000 | nM | Ki | J Med Chem (2004) 47: 1434-47 [PMID:14998332] |
ChEMBL | Binding affinity of compound for displacement of specific [3H]MRE3008-F20 binding at human A3 receptors expressed in CHO cells | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2004) 47: 1434-1447 [PMID:14998332] |
ChEMBL | Displacement of [3H]MRE3008F20 from human adenosine A3 receptor expressed in CHO cells | B | 6 | pKi | >1000 | nM | Ki | Bioorg Med Chem (2008) 16: 2419-2430 [PMID:18077171] |
ChEMBL | Binding affinity to human adenosine A3 receptor | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2009) 52: 3994-4006 [PMID:19569717] |
ChEMBL | Antagonist activity against human adenosine A3 receptor | F | 6 | pKi | >1000 | nM | Ki | Eur J Med Chem (2010) 45: 3459-3471 [PMID:20537438] |
ChEMBL | Displacement of [3H]MRE3008-F20 from human recombinant adenosine A3 receptor expressed in CHO cells after 120 mins by scintillation counting | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2012) 55: 797-811 [PMID:22148859] |
ChEMBL | Binding affinity to human adenosine A3 receptor | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2012) 55: 797-811 [PMID:22148859] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]