succinic acid [Ligand Id: 3637] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL576 (E363, Succinic acid)
  • egl-9 family hypoxia inducible factor 1/Egl nine homolog 1 in Human [ChEMBL: CHEMBL5697] [GtoPdb: 2833] [UniProtKB: Q9GZT9]
  • This target only has 0 pki data point
  • 0
1 CHEMBL576_lig_chart_1 Egl nine homolog 1 Human
There should be some charts here, you may need to enable JavaScript!
  • succinate receptor in Human [GtoPdb: 166] [UniProtKB: Q9BXA5]
  • This target only has 0 pki data point
  • 0
2 CHEMBL576_lig_chart_2 succinate receptor Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
egl-9 family hypoxia inducible factor 1/Egl nine homolog 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5697] [GtoPdb: 2833] [UniProtKB: Q9GZT9]
ChEMBL Binding affinity to human PHD2 by nondenaturing ESI-MS B 4 pKd >100000 nM Kd J. Med. Chem. (2010) 53: 867-875 [PMID:20025281]
ChEMBL Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature B 4 pKd >100000 nM Kd J. Med. Chem. (2010) 53: 867-875 [PMID:20025281]
ChEMBL Inhibition of human PHD2 at 293K temperature by solvent relaxation technique B 4.07 pIC50 85300 nM IC50 J. Med. Chem. (2010) 53: 867-875 [PMID:20025281]
ChEMBL Inhibition of 2-oxoglutarate-dependent human recombinant HIF PHD2 preincubated for 1 hr B 5.52 pIC50 3000 nM IC50 J. Med. Chem. (2008) 51: 7053-7056 [PMID:18942826]
succinate receptor in Human [GtoPdb: 166] [UniProtKB: Q9BXA5]
GtoPdb - - 4.7 pEC50 20000 nM EC50 Nature (2004) 429: 188-93 [PMID:15141213];
J Biomol Screen (2013) 18: 599-609 [PMID:23396314]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]