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ChEMBL ligand: CHEMBL1082152 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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cyclin dependent kinase 19/Cell division cycle 2-like protein kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6002] [GtoPdb: 1972] [UniProtKB: Q9BWU1] | ||||||||
ChEMBL | Inhibition of CDK11 | B | 4.4 | pKd | 40000 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
cyclin dependent kinase 8/Cell division protein kinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5719] [GtoPdb: 1980] [UniProtKB: P49336] | ||||||||
ChEMBL | Inhibition of CDK8 | B | 4.4 | pKd | 40000 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
ChEMBL | Inhibition of CDK2 | B | 6.82 | pKd | 150 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
cyclin dependent kinase 3/Cyclin-dependent kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4442] [GtoPdb: 1975] [UniProtKB: Q00526] | ||||||||
ChEMBL | Inhibition of CDK3 | B | 7.1 | pKd | 80 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
cyclin dependent kinase 5/Cyclin-dependent kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4036] [GtoPdb: 1977] [UniProtKB: Q00535] | ||||||||
ChEMBL | Inhibition of CDK5 | B | 5.17 | pKd | 6800 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
cyclin dependent kinase 7/Cyclin-dependent kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3055] [GtoPdb: 1979] [UniProtKB: P50613] | ||||||||
ChEMBL | Inhibition of CDK7 | B | 7.39 | pKd | 41 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
cyclin dependent kinase 9/Cyclin-dependent kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3116] [GtoPdb: 1981] [UniProtKB: P50750] | ||||||||
ChEMBL | Inhibition of CDK9 | B | 6.39 | pKd | 410 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
CDC like kinase 2/Dual specificity protein kinase CLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760] | ||||||||
ChEMBL | Inhibition of CLK2 | B | 8 | pKd | 10 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
CDC like kinase 3/Dual specificity protein kinase CLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761] | ||||||||
ChEMBL | Inhibition of CLK3 | B | 6.51 | pKd | 310 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
CDC like kinase 4/Dual specificity protein kinase CLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1] | ||||||||
ChEMBL | Inhibition of CLK4 | B | 6.96 | pKd | 110 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
TTK protein kinase/Dual specificity protein kinase TTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981] | ||||||||
ChEMBL | Inhibition of TTK | B | 5.17 | pKd | 6700 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463] | ||||||||
ChEMBL | Inhibition of DYRK1B | B | 7.06 | pKd | 87 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
CDC like kinase 1/Dual specificty protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759] | ||||||||
ChEMBL | Inhibition of CLK1 | B | 7.8 | pKd | 16 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840] | ||||||||
ChEMBL | Inhibition of GSK3alpha | B | 8.82 | pKd | 1.5 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counting | B | 10.28 | pKd | 0.05 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
ChEMBL | Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counting | B | 9.22 | pIC50 | 0.6 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525] | ||||||||
ChEMBL | Inhibition of PRKR | B | 4.85 | pKd | 14000 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361] | ||||||||
ChEMBL | Inhibition of ERK1 | B | 4.4 | pKd | 40000 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
ChEMBL | Inhibition of ERK2 | B | 4.4 | pKd | 40000 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
mitogen-activated protein kinase 15/Mitogen-activated protein kinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5198] [GtoPdb: 2090] [UniProtKB: Q8TD08] | ||||||||
ChEMBL | Inhibition of ERK8 | B | 7.49 | pKd | 32 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
mitogen-activated protein kinase 4/Mitogen-activated protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5759] [GtoPdb: 2091] [UniProtKB: P31152] | ||||||||
ChEMBL | Inhibition of ERK4 | B | 4.4 | pKd | 40000 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
mitogen-activated protein kinase 6/Mitogen-activated protein kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5121] [GtoPdb: 2092] [UniProtKB: Q16659] | ||||||||
ChEMBL | Inhibition of ERK3 | B | 4.4 | pKd | 40000 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
mitogen-activated protein kinase 7/Mitogen-activated protein kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5332] [GtoPdb: 2093] [UniProtKB: Q13164] | ||||||||
ChEMBL | Inhibition of ERK5 | B | 5.25 | pKd | 5600 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252] | ||||||||
ChEMBL | Inhibition of PKCalpha | B | 6.4 | pIC50 | 400 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
serine/threonine kinase 16/Serine/threonine-protein kinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3938] [GtoPdb: 2213] [UniProtKB: O75716] | ||||||||
ChEMBL | Inhibition of STK16 | B | 6.64 | pKd | 230 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] | ||||||||
ChEMBL | Inhibition of AURKA | B | 4.4 | pKd | 40000 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] | ||||||||
ChEMBL | Inhibition of AURKB | B | 4.4 | pKd | 40000 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
aurora kinase C/Serine/threonine-protein kinase Aurora-C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3935] [GtoPdb: 1938] [UniProtKB: Q9UQB9] | ||||||||
ChEMBL | Inhibition of AURKC | B | 4.64 | pKd | 23000 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
cyclin dependent kinase 16/Serine/threonine-protein kinase PCTAIRE-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4597] [GtoPdb: 1969] [UniProtKB: Q00536] | ||||||||
ChEMBL | Inhibition of PCTK1 | B | 7.92 | pKd | 12 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
cyclin dependent kinase 17/Serine/threonine-protein kinase PCTAIRE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5790] [GtoPdb: 1970] [UniProtKB: Q00537] | ||||||||
ChEMBL | Inhibition of PCTK2 | B | 7.16 | pKd | 69 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
cyclin dependent kinase 18/Serine/threonine-protein kinase PCTAIRE-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5316] [GtoPdb: 1971] [UniProtKB: Q07002] | ||||||||
ChEMBL | Inhibition of PCTK3 | B | 6.96 | pKd | 110 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] | ||||||||
ChEMBL | Inhibition of PLK1 | B | 4.64 | pKd | 23000 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
polo like kinase 3/Serine/threonine-protein kinase PLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4897] [GtoPdb: 2170] [UniProtKB: Q9H4B4] | ||||||||
ChEMBL | Inhibition of PLK3 | B | 4.4 | pKd | 40000 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
polo like kinase 4/Serine/threonine-protein kinase PLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3788] [GtoPdb: 2171] [UniProtKB: O00444] | ||||||||
ChEMBL | Inhibition of PLK4 | B | 6.49 | pKd | 320 | nM | Kd | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
CCR2 in Human [GtoPdb: 59] [UniProtKB: P41597] | ||||||||
GtoPdb | - | - | 7.6 | pKi | 25.1 | nM | Ki |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]