LTC4 [Ligand Id: 3354] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL451509 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CysLT1 receptor/Cysteinyl leukotriene receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1798] [GtoPdb: 269] [UniProtKB: Q9Y271] | ||||||||
| GtoPdb | - | - | 8.1 | pKi | - | - | - | Mol Pharmacol (1998) 53: 750-8 [PMID:9547367] |
| GtoPdb | - | - | 6.46 | pIC50 | 346 | nM | IC50 | Nature (1999) 399: 789-93 [PMID:10391245] |
| ChEMBL | Agonist activity at human CysLT1 receptor | F | 7.37 | pEC50 | 43 | nM | EC50 | J Med Chem (2021) 64: 16512-16529 [PMID:34767347] |
| GtoPdb | - | - | 7.68 | pEC50 | 21 | nM | EC50 | Nature (1999) 399: 789-93 [PMID:10391245] |
| GtoPdb | - | - | 7.7 | pEC50 | 20 | nM | EC50 |
Mol Pharmacol (1999) 56: 657-63 [PMID:10462554]; Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337]; Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801] |
| CysLT2 receptor/Cysteinyl leukotriene receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4330] [GtoPdb: 270] [UniProtKB: Q9NS75] | ||||||||
| GtoPdb | - | - | 8.48 | pIC50 | 3.3 | nM | IC50 |
J Biol Chem (2000) 275: 30531-6 [PMID:10851239]; Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801] |
| GtoPdb | - | - | 7.24 | pEC50 | 58 | nM | EC50 |
J Biol Chem (2000) 275: 30531-6 [PMID:10851239]; Mol Pharmacol (2011) 79: 270-8 [PMID:21078884] |
| GtoPdb | - | - | 7.24 | pEC50 | 57 | nM | EC50 | FASEB J (2011) 25: 3519-28 [PMID:21753081] |
| GtoPdb | - | - | 7.27 | pEC50 | 54 | nM | EC50 | Mol Pharmacol (2011) 79: 270-8 [PMID:21078884] |
| ChEMBL | Agonist activity at human CysLT2 receptor | F | 8.05 | pEC50 | 8.9 | nM | EC50 | J Med Chem (2021) 64: 16512-16529 [PMID:34767347] |
| GtoPdb | - | - | 8.64 | pEC50 | 2.3 | nM | EC50 |
Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337]; Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801] |
| GPR17 in Human [GtoPdb: 88] [UniProtKB: Q13304] | ||||||||
| GtoPdb | [35S]GTPγS binding to 1321N1 cell membranes expressing hGPR17. | - | 9.48 | pEC50 | 0.33 | nM | EC50 | EMBO J (2006) 25: 4615-27 [PMID:16990797] |
| GPR17 in Mouse [GtoPdb: 88] [UniProtKB: Q6NS65] | ||||||||
| GtoPdb | - | - | 9.13 | pEC50 | 0.74 | nM | EC50 | PLoS ONE (2008) 3: e3579 [PMID:18974869] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
