ecopipam [Ligand Id: 3304] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL298406 (Ecopipam, SCH-39166) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] | ||||||||
| GtoPdb | - | - | 8.3 | pKi | 5 | nM | Ki | Pharmacol Biochem Behav (1994) 49: 567-71 [PMID:7862709] |
| ChEMBL | Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1 | B | 8.72 | pKi | 1.9 | nM | Ki | J Med Chem (1990) 33: 2197-2204 [PMID:1973733] |
| ChEMBL | Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1 | B | 8.72 | pKi | 1.9 | nM | Ki | J Med Chem (1992) 35: 502-507 [PMID:1531365] |
| ChEMBL | Binding affinity to dopamine D1 receptor | B | 8.92 | pKi | 1.2 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 836-840 [PMID:20061148] |
| ChEMBL | Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting | B | 8.92 | pKi | 1.2 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 832-835 [PMID:20064718] |
| ChEMBL | Binding affinity to human dopamine D1 receptor | B | 9.05 | pKi | 0.9 | nM | Ki | Bioorg Med Chem Lett (2020) 30: 127563-127563 [PMID:32976928] |
| D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901] | ||||||||
| ChEMBL | Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1 | B | 8.72 | pKi | 1.9 | nM | Ki | J Med Chem (1989) 32: 1913-1921 [PMID:2666667] |
| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Binding affinity to human dopamine D2 receptor | B | 5.91 | pKi | 1240 | nM | Ki | Bioorg Med Chem Lett (2020) 30: 127563-127563 [PMID:32976928] |
| ChEMBL | Binding affinity to dopamine D2 receptor | B | 6.01 | pKi | 980 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 836-840 [PMID:20061148] |
| ChEMBL | Displacement of [3H]methylspiperon from dopamine D2 receptor expressed in mouse LTK cells by scintillation counting | B | 6.01 | pKi | 980 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 832-835 [PMID:20064718] |
| D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
| ChEMBL | Displacement of [3H]spiperone from rat striatal homogenate dopamine receptor D2 | B | 6.29 | pKi | 514 | nM | Ki | J Med Chem (1989) 32: 1913-1921 [PMID:2666667] |
| D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
| ChEMBL | Displacement of radioligand from dopamine D4 receptor expressed in mouse LTK cells by scintillation counting | B | 5.26 | pKi | 5520 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 832-835 [PMID:20064718] |
| ChEMBL | Binding affinity to dopamine D4 receptor | B | 5.26 | pKi | 5515 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 836-840 [PMID:20061148] |
| D5 receptor/Dopamine D5 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1850] [GtoPdb: 218] [UniProtKB: P21918] | ||||||||
| GtoPdb | - | - | 8.3 | pKi | - | - | - | Nature (1991) 350: 614-9 [PMID:1826762] |
| ChEMBL | Binding affinity to dopamine D5 receptor | B | 8.7 | pKi | 2 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 836-840 [PMID:20061148] |
| ChEMBL | Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting | B | 8.7 | pKi | 2 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 832-835 [PMID:20064718] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
