ecopipam [Ligand Id: 3304] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL298406 (Ecopipam, SCH-39166) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] | ||||||||
| GtoPdb | - | - | 8.3 | pKi | 5 | nM | Ki | Pharmacol Biochem Behav (1994) 49: 567-71 [PMID:7862709] |
| ChEMBL | Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1 | B | 8.72 | pKi | 1.9 | nM | Ki | J Med Chem (1990) 33: 2197-2204 [PMID:1973733] |
| ChEMBL | Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1 | B | 8.72 | pKi | 1.9 | nM | Ki | J Med Chem (1992) 35: 502-507 [PMID:1531365] |
| ChEMBL | Binding affinity to dopamine D1 receptor | B | 8.92 | pKi | 1.2 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 836-840 [PMID:20061148] |
| ChEMBL | Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting | B | 8.92 | pKi | 1.2 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 832-835 [PMID:20064718] |
| ChEMBL | Binding affinity to human dopamine D1 receptor | B | 9.05 | pKi | 0.9 | nM | Ki | Bioorg Med Chem Lett (2020) 30: 127563-127563 [PMID:32976928] |
| D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901] | ||||||||
| ChEMBL | Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1 | B | 8.72 | pKi | 1.9 | nM | Ki | J Med Chem (1989) 32: 1913-1921 [PMID:2666667] |
| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Binding affinity to human dopamine D2 receptor | B | 5.91 | pKi | 1240 | nM | Ki | Bioorg Med Chem Lett (2020) 30: 127563-127563 [PMID:32976928] |
| ChEMBL | Binding affinity to dopamine D2 receptor | B | 6.01 | pKi | 980 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 836-840 [PMID:20061148] |
| ChEMBL | Displacement of [3H]methylspiperon from dopamine D2 receptor expressed in mouse LTK cells by scintillation counting | B | 6.01 | pKi | 980 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 832-835 [PMID:20064718] |
| D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
| ChEMBL | Displacement of [3H]spiperone from rat striatal homogenate dopamine receptor D2 | B | 6.29 | pKi | 514 | nM | Ki | J Med Chem (1989) 32: 1913-1921 [PMID:2666667] |
| D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
| ChEMBL | Displacement of radioligand from dopamine D4 receptor expressed in mouse LTK cells by scintillation counting | B | 5.26 | pKi | 5520 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 832-835 [PMID:20064718] |
| ChEMBL | Binding affinity to dopamine D4 receptor | B | 5.26 | pKi | 5515 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 836-840 [PMID:20061148] |
| D5 receptor/Dopamine D5 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1850] [GtoPdb: 218] [UniProtKB: P21918] | ||||||||
| GtoPdb | - | - | 8.3 | pKi | - | - | - | Nature (1991) 350: 614-9 [PMID:1826762] |
| ChEMBL | Binding affinity to dopamine D5 receptor | B | 8.7 | pKi | 2 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 836-840 [PMID:20061148] |
| ChEMBL | Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting | B | 8.7 | pKi | 2 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 832-835 [PMID:20064718] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
