[3H]NGD941 [Ligand Id: 3297] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL103772 ([3H]NGD-941) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Binding affinity on human Dopamine receptor D2 expressed in CHO cells using radioligand [3H]-YM 09151 | B | 5.65 | pKi | 2250 | nM | Ki | J Med Chem (1997) 40: 1-3 [PMID:9016321] |
| ChEMBL | Inhibition of human dopamine D2 receptor | B | 5.65 | pKi | 2230 | nM | Ki | J Med Chem (2017) 60: 7233-7243 [PMID:28489950] |
| D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
| ChEMBL | Binding affinity on human Dopamine receptor D3 expressed in CHO cells using radioligand [3H]-YM 09151 | B | 5.1 | pKi | >8000 | nM | Ki | J Med Chem (1997) 40: 1-3 [PMID:9016321] |
| D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
| GtoPdb | - | - | 8.3 | pKd | 5 | nM | Kd | J Pharmacol Exp Ther (1997) 282: 1020-7 [PMID:9262371] |
| ChEMBL | Binding affinity on human Dopamine receptor D4 expressed in CHO cells using radioligand [3H]-YM 09151 | B | 8.42 | pKi | 3.8 | nM | Ki | J Med Chem (1997) 40: 1-3 [PMID:9016321] |
| ChEMBL | Binding affinity towards human dopamine receptor D4 | B | 8.44 | pKi | 3.6 | nM | Ki | J Med Chem (2001) 44: 477-501 [PMID:11170639] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Binding affinity against 5-hydroxytryptamine 1A receptor | B | 6.74 | pKi | 181 | nM | Ki | J Med Chem (1997) 40: 1-3 [PMID:9016321] |
| ChEMBL | Inhibition of serotonin 5-HT1A receptor (unknown origin) | B | 6.74 | pKi | 180 | nM | Ki | J Med Chem (2017) 60: 7233-7243 [PMID:28489950] |
| 5-HT3A/Serotonin 3a (5-HT3a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098] | ||||||||
| ChEMBL | Inhibition of serotonin 5-HT3 receptor (unknown origin) | B | 6.12 | pKi | 750 | nM | Ki | J Med Chem (2017) 60: 7233-7243 [PMID:28489950] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
