VUF5574 [Ligand Id: 3280] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL70880 (VUF-5574) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
| GtoPdb | - | - | 5 | pKi | <10000 | nM | Ki | J Med Chem (1998) 41: 3987-93 [PMID:9767636] |
| ChEMBL | Displacement of [3H]DPCPX binding to adenosine A1 receptor of rat brain cortical membrane | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2001) 44: 749-762 [PMID:11262085] |
| A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] | ||||||||
| GtoPdb | - | - | 5 | pKi | <10000 | nM | Ki | J Med Chem (1998) 41: 3987-93 [PMID:9767636] |
| ChEMBL | Displacement of [3H]-CGS- 21680 binding in adenosine A2A receptor of rat striatal membrane | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2001) 44: 749-762 [PMID:11262085] |
| A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
| ChEMBL | Percent displacement of [3H]DPCPX binding in human adenosine A2B receptor expressed in COS-7 cells | B | 5 | pKi | 10000 | nM | Ki | J Med Chem (2001) 44: 749-762 [PMID:11262085] |
| A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
| ChEMBL | Binding affinity by its ability to displace [125I]AB-MECA from human adenosine A3 receptor expressed in HEK 293 cells | B | 5.39 | pKi | 4030 | nM | Ki | J Med Chem (2000) 43: 2227-2238 [PMID:10841801] |
| GtoPdb | - | - | 8.39 | pKi | 4.03 | nM | Ki | J Med Chem (2000) 43: 2227-38 [PMID:10841801] |
| ChEMBL | Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in HEK 293 cells | B | 8.4 | pKi | 4 | nM | Ki | J Med Chem (2001) 44: 749-762 [PMID:11262085] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | F | 5.6 | pIC50 | 2511.89 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
