ChEMBL ligand: CHEMBL139835 (Androcur, Androcur 10, Ciproterona, Cyprostat, Cyproterone, Cyproterone 17.alpha.-acetate, Cyproterone acetate, Diane, NSC-81430, SH 714, SH-714, SH714)
A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] There should be some charts here, you may need to enable JavaScript!
Androgen receptor/Androgen Receptor in Human [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275] Androgen receptor/Androgen Receptor in Rat [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207] There should be some charts here, you may need to enable JavaScript!
Glucocorticoid receptor in Human [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Progesterone receptor in Human [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401] Progesterone receptor in Bovine [ChEMBL: CHEMBL1909044] [UniProtKB: Q690N0] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL	Adenosine A1 receptor binding was measured in adenosine deaminase (ADA) pretreated rat cortical membranes using [3H]cyclohexyladenosine in the presence of 2-chloroadenosine	B	8.89	pKi	1.3	nM	Ki	J Med Chem (1990) 33: 1919-1924 [PMID:2362269]
ChEMBL	Binding affinity against adenosine A1 receptor from rat brain membranes using [3H]cyclohexyladenosine as radioligand.	B	9.12	pKi	0.76	nM	Ki	J Med Chem (1992) 35: 2881-2890 [PMID:1495019]
ChEMBL	Displacement of [3H]DPCPX from adenosine A1 receptor of rat cortical membranes with GTP	B	6.9	pIC50	125	nM	IC50	J Med Chem (2004) 47: 2243-2255 [PMID:15084123]
ChEMBL	Displacement of [3H]DPCPX from adenosine A1 receptor of rat cortical membranes without GTP	B	8.3	pIC50	5	nM	IC50	J Med Chem (2004) 47: 2243-2255 [PMID:15084123]
Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275]
GtoPdb	-	-	7.85	pKi	14	nM	Ki	J Med Chem (1998) 41: 623-39 [PMID:9484511]
ChEMBL	Binding affinity for human androgen receptor in transiently-transfected COS-1 cells.	B	7.85	pKi	14	nM	Ki	J Med Chem (1998) 41: 623-639 [PMID:9484511]
ChEMBL	Antagonist activity at human AR AF2 assessed as inhibition of fluorescent-labelled D11-FxxLF peptide Co-activator to receptor by TR-FRET assay	B	6.59	pIC50	258.6	nM	IC50	J Med Chem (2022) 65: 2507-2521 [PMID:35077161]
ChEMBL	Antagonistic activity against human androgen receptor (hAR) in co-transfected CV-1 cells.	F	7.64	pIC50	23	nM	IC50	J Med Chem (1998) 41: 623-639 [PMID:9484511]
Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
ChEMBL	DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone)	B	7.51	pKi	31	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibition of [3H]-R-1881 binding to rat ventral prostate cytosolic androgen receptor	B	4.74	pIC50	18000	nM	IC50	J Med Chem (2000) 43: 4629-4635 [PMID:11101354]
ChEMBL	Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)	B	6.2	pIC50	630.96	nM	IC50	J Med Chem (2005) 48: 5666-5674 [PMID:16134935]
ChEMBL	DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone)	B	7.33	pIC50	47	nM	IC50	DrugMatrix in vitro pharmacology data
Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150]
ChEMBL	DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)	B	6.99	pKi	102	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)	B	6.65	pIC50	225	nM	IC50	DrugMatrix in vitro pharmacology data
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)	B	6.05	pKi	886	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)	B	5.66	pIC50	2183	nM	IC50	DrugMatrix in vitro pharmacology data
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay	F	5.1	pIC50	7943.28	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
Progesterone receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401]
ChEMBL	Antagonistic activity against human progesterone receptor B (hPR-B) in co-transfected CV-1 cells.	F	6	pIC50	>1000	nM	IC50	J Med Chem (1998) 41: 623-639 [PMID:9484511]
Progesterone receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1909044] [UniProtKB: Q690N0]
ChEMBL	DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)	B	8.31	pKi	4.84	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)	B	7.43	pIC50	37	nM	IC50	DrugMatrix in vitro pharmacology data

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]