ChEMBL ligand: CHEMBL431298 (SB-271046)
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368] There should be some charts here, you may need to enable JavaScript!
D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] There should be some charts here, you may need to enable JavaScript!
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] There should be some charts here, you may need to enable JavaScript!
D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] There should be some charts here, you may need to enable JavaScript!
D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] There should be some charts here, you may need to enable JavaScript!
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222] There should be some charts here, you may need to enable JavaScript!
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221] There should be some charts here, you may need to enable JavaScript!
5-ht1e receptor/Serotonin 1e (5-HT1e) receptor in Human [ChEMBL: CHEMBL2182] [GtoPdb: 4] [UniProtKB: P28566] There should be some charts here, you may need to enable JavaScript!
5-HT1F receptor/Serotonin 1f (5-HT1f) receptor in Human [ChEMBL: CHEMBL1805] [GtoPdb: 5] [UniProtKB: P30939] There should be some charts here, you may need to enable JavaScript!
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] There should be some charts here, you may need to enable JavaScript!
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] There should be some charts here, you may need to enable JavaScript!
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] There should be some charts here, you may need to enable JavaScript!
5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Human [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639] There should be some charts here, you may need to enable JavaScript!
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] There should be some charts here, you may need to enable JavaScript!
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
ChEMBL	The compound was tested for the binding affinity towards Alpha-1B adrenergic receptor	B	5.7	pKi	1995.26	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1357-1360 [PMID:11992776]
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
ChEMBL	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	B	6.92	pKi	120	nM	Ki	Bioorg Med Chem Lett (2008) 18: 738-743 [PMID:18053713]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL	The compound was tested for the binding affinity towards human cloned Dopamine receptor D2 in CHO cells, using [125I]iodosulpride as radioligand	B	5.6	pKi	2511.89	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1357-1360 [PMID:11992776]
ChEMBL	Displacement of [3H]spiperone from human cloned dopamine D2 receptor	B	6.34	pKi	460	nM	Ki	Bioorg Med Chem Lett (2008) 18: 738-743 [PMID:18053713]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL	Displacement of [3H]spiperone from human cloned dopamine D3 receptor	B	5.88	pKi	1330	nM	Ki	Bioorg Med Chem Lett (2008) 18: 738-743 [PMID:18053713]
ChEMBL	The compound was tested for the binding affinity towards human cloned Dopamine receptor D3 in CHO cells, using [125I]iodosulpride as radioligand	B	6.3	pKi	501.19	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1357-1360 [PMID:11992776]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL	Displacement of [3H]spiperone from human cloned dopamine D4 receptor	B	6.89	pKi	130	nM	Ki	Bioorg Med Chem Lett (2008) 18: 738-743 [PMID:18053713]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1A receptor in HEK293 cells, using [3H]8-OH-DPAT as radioligand	B	6.4	pKi	398.11	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1357-1360 [PMID:11992776]
ChEMBL	Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor	B	6.47	pKi	340	nM	Ki	Bioorg Med Chem Lett (2008) 18: 738-743 [PMID:18053713]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
ChEMBL	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1B receptor in CHO cells, using [3H]5-HT as radioligand	B	6.1	pKi	794.33	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1357-1360 [PMID:11992776]
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
ChEMBL	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligand	B	6.6	pKi	251.19	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1357-1360 [PMID:11992776]
5-ht1e receptor/Serotonin 1e (5-HT1e) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2182] [GtoPdb: 4] [UniProtKB: P28566]
ChEMBL	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1E receptor in CHO cells, using [3H]5-HT as radioligand	B	5	pKi	<10000	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1357-1360 [PMID:11992776]
5-HT1F receptor/Serotonin 1f (5-HT1f) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1805] [GtoPdb: 5] [UniProtKB: P30939]
ChEMBL	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligand	B	6	pKi	<1000	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1357-1360 [PMID:11992776]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2A receptor in HEK293 cells, using [3H]ketanserin as radioligand	B	5.6	pKi	<2511.89	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1357-1360 [PMID:11992776]
ChEMBL	Displacement of [3H]ketanserin from human cloned 5HT2A receptor	B	5.76	pKi	1740	nM	Ki	Bioorg Med Chem Lett (2008) 18: 738-743 [PMID:18053713]
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
ChEMBL	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	B	5.4	pKi	<3981.07	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1357-1360 [PMID:11992776]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2C receptor in HEK293 cells, using [3H]5-mesulergine as radioligand	B	5.7	pKi	1995.26	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1357-1360 [PMID:11992776]
ChEMBL	Displacement of [3H]5-HT from 5-HT2C receptor (unknown origin) expressed in hamster AV12 cells	B	6.11	pKi	776.25	nM	Ki	J Med Chem (2014) 57: 5823-5828 [PMID:24878269]
ChEMBL	Displacement of [3H]5-HT from 5-HT2C receptor (unknown origin) expressed in hamster AV12 cells	B	6.11	pKi	770	nM	Ki	J Med Chem (2014) 57: 5823-5828 [PMID:24878269]
ChEMBL	Displacement of [3H]mesulergine from human cloned 5HT2C receptor	B	6.28	pKi	530	nM	Ki	Bioorg Med Chem Lett (2008) 18: 738-743 [PMID:18053713]
5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639]
ChEMBL	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 4 receptor in HeLa cells, using [3H]LSD as radioligand	B	5.4	pKi	3981.07	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1357-1360 [PMID:11992776]
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL	Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells by liquid scintillation counting	B	7.89	pKi	13	nM	Ki	J Med Chem (2009) 52: 675-687 [PMID:19159187]
ChEMBL	Displacement of [3H]LSD from human 5-HT6 receptor expressed in hamster BHK cells after 60 mins by scintillation counting analysis	B	8.52	pKi	3.02	nM	Ki	J Med Chem (2014) 57: 5823-5828 [PMID:24878269]
ChEMBL	Displacement of [3H]LSD from human 5-HT6 receptor expressed in hamster BHK cells after 60 mins by scintillation counting analysis	B	8.52	pKi	3	nM	Ki	J Med Chem (2014) 57: 5823-5828 [PMID:24878269]
ChEMBL	Displacement of [3H]LSD from human 5-HT6 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	B	8.77	pKi	1.7	nM	Ki	Eur J Med Chem (2015) 92: 807-817 [PMID:25637882]
ChEMBL	Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells	B	8.89	pKi	1.3	nM	Ki	J Med Chem (2014) 57: 7160-7181 [PMID:24850589]
ChEMBL	Displacement of [3H]LSD from human 5HT6 receptor expressed in HeLa cells	B	8.89	pKi	1.3	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3214-3216 [PMID:19433358]
ChEMBL	Displacement of [3H]LSD from human 5-hydroxytryptamine 6 receptor expressed in HEK 293 cells	B	8.89	pKi	1.3	nM	Ki	Bioorg Med Chem Lett (2000) 10: 1719-1721 [PMID:10937732]
ChEMBL	Displacement of [3H]LSD from human 5-hydroxytryptamine 6 receptor expressed in HeLa cells	B	8.9	pKi	1.26	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4867-4871 [PMID:16143522]
ChEMBL	Binding affinity against human 5-hydroxytryptamine 6 receptor	B	8.9	pKi	1.26	nM	Ki	Bioorg Med Chem Lett (2001) 11: 2843-2846 [PMID:11597412]
ChEMBL	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 6 receptor in HeLa cells, using [3H]LSD as radioligand; n=3	B	8.9	pKi	1.26	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1357-1360 [PMID:11992776]
ChEMBL	Binding affinity to 5HT6 receptor	B	8.9	pKi	1.26	nM	Ki	Bioorg Med Chem Lett (2011) 21: 698-703 [PMID:21190848]
GtoPdb	-	-	8.9	pKi	1.26	nM	Ki	J Med Chem (1999) 42: 202-5 [PMID:9925723]
ChEMBL	Binding affinity towards human 5-hydroxytryptamine 6 receptor	B	9	pKi	1	nM	Ki	J Med Chem (2003) 46: 2795-2812 [PMID:12825922]
ChEMBL	Binding affinity against 5 Hydroxy tryptamine 6 receptor	B	9	pKi	1	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1707-1711 [PMID:15745826]
ChEMBL	Binding affinity for human 5-hydroxytryptamine 6 receptor	B	9	pKi	1	nM	Ki	J Med Chem (2005) 48: 4216-4219 [PMID:15974573]
ChEMBL	Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in HEK293 cells	B	9	pKi	1	nM	Ki	Bioorg Med Chem Lett (2008) 18: 738-743 [PMID:18053713]
ChEMBL	Inhibition of [3H]LSD binding to human 5-hydroxytryptamine 6 receptor expressed in HEK293 cells	B	9.1	pKi	0.8	nM	Ki	J Med Chem (2005) 48: 1781-1795 [PMID:15771424]
ChEMBL	Displacement of [3H]LSD from human recombinant 5HT6 receptor	B	9.18	pKi	0.66	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2409-2412 [PMID:19346128]
ChEMBL	Displacement of [3H]-LSD from human 5-HT6R expressed in human HeLa cells after 1 hr by liquid scintillation counting method	B	9.2	pKi	0.63	nM	Ki	Eur J Med Chem (2017) 135: 117-124 [PMID:28441580]
ChEMBL	Inhibition of human recombinant 5HT6 receptor expressed in CHO cells	B	8.7	pIC50	2	nM	IC50	J Med Chem (2014) 57: 7160-7181 [PMID:24850589]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
ChEMBL	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	B	5.4	pKi	3981.07	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1357-1360 [PMID:11992776]
ChEMBL	Displacement of [3H]LSD from human cloned 5HT7 receptor	B	6.59	pKi	260	nM	Ki	Bioorg Med Chem Lett (2008) 18: 738-743 [PMID:18053713]
ChEMBL	Displacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter method	B	8.52	pKi	3	nM	Ki	Eur J Med Chem (2021) 210: 113059-113059 [PMID:33310288]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]