fexaramine [Ligand Id: 2744] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL192966 (Fexaramine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Farnesoid X receptor/Bile acid receptor FXR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2047] [GtoPdb: 603] [UniProtKB: Q96RI1] | ||||||||
| ChEMBL | Agonist activity at human FXR transfected in CHO-K1 cells coexpressed with beta-galactosidase incubated for 3 to 16 hrs by PathHunter chemiluminescence based assay | B | 6.1 | pEC50 | 800 | nM | EC50 | J Med Chem (2022) 65: 9974-10000 [PMID:35797110] |
| GtoPdb | - | - | 6.6 | pEC50 | - | - | - | Mol Cell (2003) 11: 1079-92 [PMID:12718892] |
| ChEMBL | Effective concentration against farnesoid X receptor (FXR) | B | 7.6 | pEC50 | 25 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 3119-3125 [PMID:15893927] |
| ChEMBL | Effective concentration against farnesoid X receptor (FXR) | B | 7.6 | pEC50 | 25 | nM | EC50 | J Med Chem (2005) 48: 5613-5638 [PMID:16134928] |
| ChEMBL | Effective concentration towards farnesoid X receptor (FXR) | B | 7.6 | pEC50 | 25 | nM | EC50 | J Med Chem (2005) 48: 5613-5638 [PMID:16134928] |
| ChEMBL | Agonist activity at FXR | F | 7.6 | pEC50 | 25 | nM | EC50 | Nat Chem Biol (2005) 1: 74-84 [PMID:16408003] |
| ChEMBL | Agonist activity at FXR | F | 7.6 | pEC50 | 25 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 6848-6853 [PMID:23040732] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
