ChEMBL ligand: CHEMBL1093059 (Bardoxolona, Bardoxolone, CDDO, RTA 401, RTA-401, RTA401)
Ghrelin O-acyltransferase in Human [ChEMBL: CHEMBL3588729] [UniProtKB: Q96T53] There should be some charts here, you may need to enable JavaScript!
kelch like ECH-associated protein 1/Kelch-like ECH-associated protein 1 in Human [ChEMBL: CHEMBL2069156] [GtoPdb: 2757] [UniProtKB: Q14145] There should be some charts here, you may need to enable JavaScript!
Inducible NOS/Nitric oxide synthase, inducible in Human [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228] Inducible NOS/Nitric oxide synthase, inducible in Mouse [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-γ in Human [GtoPdb: 595] [UniProtKB: P37231] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Ghrelin O-acyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3588729] [UniProtKB: Q96T53]
ChEMBL	Inhibition of human GOAT expressed in Sf9 cell membranes assessed as reduction in ghrelin octanoylation pre-incubated for 15 mins before substrate addition and measured after 3 hrs using octanoyl-CoA and fluorescent ghrelin peptide by HPLC analysis	B	4	pIC50	>100000	nM	IC50	US-20170056373-A1. Ghrelin o-acyltransferase inhibitors (2017)
kelch like ECH-associated protein 1/Kelch-like ECH-associated protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069156] [GtoPdb: 2757] [UniProtKB: Q14145]
ChEMBL	Binding affinity to Keap1 (unknown origin) assessed as dissociation constant incubated for 200 sec by sensor chip immobilization based surface plasmon resonance analysis	B	4.31	pKd	48720	nM	Kd	J Med Chem (2023) 66: 9184-9200 [PMID:37386884]
GtoPdb	Measuring inhibition of KEAP1 binding to Cul3 using an AlphaScreen bead-based proximity assay.	-	7	pIC50	<100	nM	IC50	PLoS ONE (2014) 9: e98896 [PMID:24896564]
Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228]
ChEMBL	Inhibition of inducible nitric oxide synthase in activated macrophages	B	9.7	pIC50	0.2	nM	IC50	Bioorg Med Chem Lett (2005) 15: 2215-2219 [PMID:15837296]
Inducible NOS/Nitric oxide synthase, inducible in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477]
ChEMBL	Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assay	B	7.64	pIC50	23	nM	IC50	J Med Chem (2015) 58: 4738-4748 [PMID:25965897]
Peroxisome proliferator-activated receptor-γ in Human [GtoPdb: 595] [UniProtKB: P37231]
GtoPdb	-	-	8	pKi	-	-	-	Mol Endocrinol (2000) 14: 1550-6 [PMID:11043571]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]