ChEMBL ligand: CHEMBL521 (Manorfen, Motrin ib, Rufen, Fenbid, Ibutime, Ibuprohm, Arthrofen 400, Junior strength ibuprofen, Orbifen, Nurofen back pain sr, Ibumed, Relcofen, Ibuprofenum, Isisfen, Nurofen sinus, Rimafen, Lidifen-f, Codafen continus, Proflex, Motrin, Pacifene, Brufen ret, Caldolor, Cuprofen plus, Advil, Apsifen, Co-op, Ibuderm, Children's ibuprofen, Femafen, RD 13621, IB-100, Ibumetin, Children's advil, Ibu-slo, Children's advil-flavored, Ibugel fte, Ibumousse, Phor pain, Apsifen-f, Nuprin, Advil liqui-gels, Ibuprofen, Ibugel, Ibuprin, Children's elixsure, Burana, Lidifen, Junior strength motrin, Nurofen child, Ibular, Cap-profen, Medipren, M01AE01, Seclodin, Phorpain max strgh, Anadin liquifast, Ibufac, Fenbid fte, Cuprofen for child, Arthrofen 200, U-18573, Profen, Nurofen for child, Ibu-tab 200, U-18,573, Nurofen solb, Deep relief, IP-82, Aches-n-pain, Feverfen, Anadin period pain relief, Phorpain, Children's motrin, NSC-256857, Advil migraine liqui-gels, Inoven, Ibuleve, Novaprin, Ibu-tab, Pedea, Ibuspray, Inabrin, Lobufen, Migrafen, Infant's advil, Motrin migraine pain, Ibucalm, Anadin joint pain, Pediatric advil, Maxa-gesic, Midol liquid gels, Arthrofen 600, Phensic, Nurofen 400, Junifen, Nurofen plus, Fleximex, Junior strength advil, Paxofen, Mandafen, Anadin ultra, Fenpaed, Tab-profen, Suspren, Ebufac, Nurofen recovery, Midol, Proflex sr)
AKR1C3/Aldo-keto-reductase family 1 member C3 in Human [ChEMBL: CHEMBL4681] [GtoPdb: 1382] [UniProtKB: P42330] There should be some charts here, you may need to enable JavaScript!
5-LOX/Arachidonate 5-lipoxygenase in Human [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917] 5-LOX/Arachidonate 5-lipoxygenase in Rat [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527] There should be some charts here, you may need to enable JavaScript!
COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] Cyclooxygenase-1 in Bovine [ChEMBL: CHEMBL2860] [UniProtKB: O62664] Cyclooxygenase-1 in Sheep [ChEMBL: CHEMBL2949] [UniProtKB: P05979] There should be some charts here, you may need to enable JavaScript!
COX-2 /Cyclooxygenase-2 in Human [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] Cyclooxygenase-2 in Bovine [ChEMBL: CHEMBL3331] [UniProtKB: O62698] Cyclooxygenase-2 in Sheep [ChEMBL: CHEMBL4102] [UniProtKB: P79208] COX-2 /Cyclooxygenase-2 in Mouse [ChEMBL: CHEMBL4321] [GtoPdb: 1376] [UniProtKB: Q05769] There should be some charts here, you may need to enable JavaScript!
Dehydrogenase/reductase SDR family member 9 in Rat [ChEMBL: CHEMBL1075220] [UniProtKB: Q8VD48] There should be some charts here, you may need to enable JavaScript!
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] There should be some charts here, you may need to enable JavaScript!
fatty acid binding protein 1/Fatty acid-binding protein, liver in Rat [ChEMBL: CHEMBL5738] [GtoPdb: 2531] [UniProtKB: P02692] There should be some charts here, you may need to enable JavaScript!
L-PGDS/Prostaglandin-H2 D-isomerase in Mouse [ChEMBL: CHEMBL4334] [GtoPdb: 1380] [UniProtKB: O09114] There should be some charts here, you may need to enable JavaScript!
Serum albumin in Bovine [ChEMBL: CHEMBL3728] [UniProtKB: P02769] There should be some charts here, you may need to enable JavaScript!
OAT6/Solute carrier family 22 member 20 in Mouse [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1] There should be some charts here, you may need to enable JavaScript!
Organic anion transporter 1/Solute carrier family 22 member 6 in Human [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8] Organic anion transporter 1/Solute carrier family 22 member 6 in Mouse [ChEMBL: CHEMBL5653] [GtoPdb: 1025] [UniProtKB: Q8VC69] Organic anion transporter 1/Solute carrier family 22 member 6 in Rat [ChEMBL: CHEMBL1777665] [GtoPdb: 1025] [UniProtKB: O35956] There should be some charts here, you may need to enable JavaScript!
ASIC1 in Human [GtoPdb: 684] [UniProtKB: P78348] There should be some charts here, you may need to enable JavaScript!
SMCT1 in Human [GtoPdb: 922] [UniProtKB: Q8N695] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
AKR1C3/Aldo-keto-reductase family 1 member C3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4681] [GtoPdb: 1382] [UniProtKB: P42330]
ChEMBL	Inhibition of recombinant human AKR1C3	B	4.48	pIC50	33000	nM	IC50	Bioorg. Med. Chem. Lett. (2005) 15: 5170-5175 [PMID:16183274]
ChEMBL	Inhibition of AKR1C3 (unknown origin)	B	5	pIC50	10000	nM	IC50	MedChemComm (2018) 9: 969-981 [PMID:30108986]
5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917]
ChEMBL	Inhibitory activity against 5-lipoxygenase in Human whole blood (HWBL) stimulated with calcium ionophore (A23187) and LTB4 measured by enzyme immunoassay	F	4.77	pIC50	17000	nM	IC50	J. Med. Chem. (1997) 40: 819-824 [PMID:9057869]
5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527]
ChEMBL	Inhibition of 5-LOX in RBL1 cells assessed as reduction in LTB4 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs followed by A23187 addition measured after 15 mins by LC-MS/MS analysis	B	4	pIC50	>100000	nM	IC50	ACS Med Chem Lett (2017) 8: 864-868 [PMID:28835803]
ChEMBL	Inhibitory activity against 5-lipoxygenase catalysis (5-LO) in sonicated rat basophilic leukemia cell lysate	F	4.85	pIC50	14000	nM	IC50	J. Med. Chem. (1997) 40: 819-824 [PMID:9057869]
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL	Inhibition of human recombinant COX1 expressed in Sf9 cells using arachidonic acid and ADHP incubated for 3 mins by fluorimetry	B	4.47	pIC50	34000	nM	IC50	J Med Chem (2020) 63: 12614-12622 [PMID:32931274]
ChEMBL	Inhibition of PGHS1 assessed as conversion of arachidonic acid to prostaglandin	B	4.6	pIC50	25000	nM	IC50	J. Nat. Prod. (1999) 62: 294-296 [PMID:10075763]
ChEMBL	Inhibition of COX1-catalyzed prostaglandin biosynthesis 10 mins of preincubation	B	4.74	pIC50	18000	nM	IC50	J. Nat. Prod. (1998) 61: 1212-1215 [PMID:9784154]
ChEMBL	Inhibition activity against recombinant human Prostaglandin G/H synthase 1	B	4.95	pIC50	11100	nM	IC50	J. Med. Chem. (1997) 40: 819-824 [PMID:9057869]
ChEMBL	Inhibition of COX1 in human whole blood after 15 mins	B	5.16	pIC50	6900	nM	IC50	Bioorg. Med. Chem. (2007) 15: 4876-4890 [PMID:17517512]
ChEMBL	Compound was evaluated for inhibition of Prostaglandin G/H synthase 1	B	5.2	pIC50	6300	nM	IC50	Bioorg. Med. Chem. Lett. (1996) 6: 707-712
GtoPdb	-	-	5.52	pIC50	3000	nM	IC50	J Med Chem (1998) 41: 1124-37 [PMID:9544212]
ChEMBL	Inhibition of Prostaglandin G/H synthase 1 (COX-1).	B	5.52	pIC50	3000	nM	IC50	J. Med. Chem. (1998) 41: 1124-1137 [PMID:9544212]
ChEMBL	Concentration (in uM) to inhibit 50% of Prostaglandin G/H synthase 1 (COX-1) and is expressed in IC50.	B	5.52	pIC50	3000	nM	IC50	J. Med. Chem. (1998) 41: 1112-1123 [PMID:9544211]
ChEMBL	Inhibitory activity against prostaglandin G/H synthase 1 (COX-1)	B	5.52	pIC50	3000	nM	IC50	J. Med. Chem. (1998) 41: 3515-3529 [PMID:9719605]
ChEMBL	Inhibition of COX-1 (unknown origin) using arachidonic acid as substrate measured after 10 mins by fluorometric based multimode microplate reader	B	5.57	pIC50	2704	nM	IC50	Eur J Med Chem (2021) 209: 112918-112918 [PMID:33071054]
ChEMBL	Inhibition of COX-1 in human washed platelet assessed as inhibition of 10 uM arachidonic acid-induced TXB2 formation incubated for 25 mins prior to arachidonic acid challenge measured after 30 mins by radioimmunoassay	B	5.73	pIC50	1860	nM	IC50	J. Med. Chem. (2013) 56: 4277-4299 [PMID:23651359]
ChEMBL	Inhibition of COX-1 in human washed platelet assessed as inhibition of 0.5 uM arachidonic acid-induced TXB2 formation incubated for 25 mins prior to arachidonic acid challenge measured after 30 mins by radioimmunoassay	B	6.54	pIC50	290	nM	IC50	J. Med. Chem. (2013) 56: 4277-4299 [PMID:23651359]
ChEMBL	DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid)	B	6.67	pIC50	212	nM	IC50	DrugMatrix in vitro pharmacology data
Cyclooxygenase-1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2860] [UniProtKB: O62664]
ChEMBL	Inhibition of bovine seminal microsomal COX1 assessed as PGE2 production preincubated for 10 mins	B	4.74	pIC50	18000	nM	IC50	J. Nat. Prod. (1998) 61: 2-7 [PMID:9461646]
ChEMBL	Inhibition of bovine seminal microsomal COX1 assessed as PGE2 production	B	4.89	pIC50	13000	nM	IC50	J. Nat. Prod. (1998) 61: 2-7 [PMID:9461646]
ChEMBL	Inhibition of bovine COX1 by enzyme immunoassay	B	5.54	pIC50	2900	nM	IC50	J. Med. Chem. (2009) 52: 1525-1529 [PMID:19296694]
ChEMBL	Inhibition of bovine COX-1 by enzyme immuno assay	B	5.54	pIC50	2900	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 6855-6861 [PMID:19884005]
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL	Inhibition of sheep placental cotyledons COX1	B	5.05	pKi	9000	nM	Ki	J. Med. Chem. (2011) 54: 8555-8562 [PMID:22091869]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 3 mins followed by substrate addition measured immediately	B	4.14	pIC50	72800	nM	IC50	J Nat Prod (2017) 80: 2472-2477 [PMID:28885836]
ChEMBL	Competitive inhibition of ovine COX-1 assessed as reduction in PGE2 production using 6250 nM arachidonic acid as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured after 20 mins by ELISA	B	4.15	pIC50	70100	nM	IC50	ACS Med Chem Lett (2021) 12: 610-616 [PMID:33854702]
ChEMBL	Inhibition of ovine COX-1 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins prior to substrate challenge for 2 mins by enzyme immunoassay	B	4.59	pIC50	26000	nM	IC50	Bioorg. Med. Chem. Lett. (2014) 24: 1958-1962 [PMID:24656662]
ChEMBL	Inhibitory concentration against Prostaglandin G/H synthase 1 of ram seminal vesicles at 100 uM	B	4.84	pIC50	14400	nM	IC50	Bioorg. Med. Chem. Lett. (2005) 15: 1793-1797 [PMID:15780608]
ChEMBL	Inhibition of ovine COX-1 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysis	B	4.92	pIC50	12000	nM	IC50	Bioorg. Med. Chem. (2011) 19: 5372-5382 [PMID:21873070]
ChEMBL	Inhibition of ovine COX1 after 5 mins	B	4.92	pIC50	12000	nM	IC50	J. Med. Chem. (2010) 53: 4691-4700 [PMID:20503989]
ChEMBL	Inhibition of purified ovine COX1 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver esterase by fluorescence assay	B	5	pIC50	10100	nM	IC50	ACS Med. Chem. Lett. (2014) 5: 983-988 [PMID:25221653]
ChEMBL	Inhibition of Ovine COX-1 preincubated for 15 mins by fluorescence analysis	B	5	pIC50	>10000	nM	IC50	ACS Med. Chem. Lett. (2015) 6: 1086-1090 [PMID:26487917]
ChEMBL	Tested for inhibitory activity against Prostaglandin G/H synthase 1 from ovine	B	5.05	pIC50	9000	nM	IC50	J. Med. Chem. (1995) 38: 3895-3901 [PMID:7562922]
ChEMBL	Inhibition of ram seminal vesicle COX1 assessed as reduction in PGE2 formation pre-incubated for 5 mins before arachidonic acid addition and measured after 20 mins by ELISA	B	5.2	pIC50	6300	nM	IC50	J Nat Prod (2017) 80: 999-1006 [PMID:28322565]
ChEMBL	Inhibition of ovine COX1 pre-incubated for 10 mins before arachidonic acid substrate addition by enzyme immunoassay	B	5.3	pIC50	5000	nM	IC50	J. Med. Chem. (2012) 55: 8807-8826 [PMID:23043222]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluorescence based enzyme immunoassay	B	5.39	pIC50	4120	nM	IC50	Eur J Med Chem (2019) 180: 86-98 [PMID:31301566]
ChEMBL	Inhibition of ovine COX-1	B	5.4	pIC50	4000	nM	IC50	J. Med. Chem. (2011) 54: 1356-1364 [PMID:21280601]
ChEMBL	Competitive inhibition of ovine COX-1 assessed as reduction in PGE2 production using 250 nM arachidonic acid as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured after 20 mins by ELISA	B	5.4	pIC50	4000	nM	IC50	ACS Med Chem Lett (2021) 12: 610-616 [PMID:33854702]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	5.54	pIC50	2900	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 6074-6080 [PMID:21890358]
ChEMBL	Inhibition of ovine COX1	B	5.54	pIC50	2900	nM	IC50	J. Med. Chem. (2012) 55: 688-696 [PMID:22148253]
ChEMBL	Inhibition of ovine COX1	B	5.54	pIC50	2900	nM	IC50	Bioorg. Med. Chem. Lett. (2013) 23: 163-168 [PMID:23200247]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	5.54	pIC50	2900	nM	IC50	Bioorg. Med. Chem. (2007) 15: 4767-4774 [PMID:17509888]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	5.54	pIC50	2900	nM	IC50	Bioorg. Med. Chem. Lett. (2016) 26: 406-412 [PMID:26691756]
ChEMBL	In vitro inhibitory concentration against COX-1 enzyme	B	5.54	pIC50	2900	nM	IC50	J. Med. Chem. (2005) 48: 4061-4067 [PMID:15943479]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	5.54	pIC50	2900	nM	IC50	Bioorg. Med. Chem. (2008) 16: 9694-9698 [PMID:18930406]
ChEMBL	Inhibition of ovine COX1 by enzyme immunoassay	B	5.54	pIC50	2900	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 3014-3018 [PMID:19419861]
ChEMBL	Inhibition of ovine COX1 by enzyme immunoassay	B	5.54	pIC50	2900	nM	IC50	Bioorg. Med. Chem. (2009) 17: 5182-5188 [PMID:19500994]
ChEMBL	Inhibition of ovine COX1 by enzyme immunoassay	B	5.54	pIC50	2900	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 1324-1329 [PMID:20097072]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	5.54	pIC50	2900	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 896-902 [PMID:20045320]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	5.54	pIC50	2900	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 2168-2173 [PMID:20202839]
ChEMBL	Inhibition of sheep COX1 by enzyme immunoassay	B	5.54	pIC50	2900	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 4544-4549 [PMID:20576432]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	5.54	pIC50	2900	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 3951-3956 [PMID:21641217]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	5.54	pIC50	2900	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 584-588 [PMID:19136259]
ChEMBL	Inhibition of ovine COX-1 assessed as reduction in PGE2 production using 10 uM arachidonic acid as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured after 20 mins by ELISA	B	5.66	pIC50	2190	nM	IC50	ACS Med Chem Lett (2021) 12: 610-616 [PMID:33854702]
ChEMBL	Inhibition of ovine COX1 assessed as reduction in Prostaglandin production by enzyme immunoassay	B	5.85	pIC50	1420	nM	IC50	Bioorg Med Chem (2018) 26: 891-902 [PMID:29373271]
ChEMBL	Reversible competitive inhibition of prostaglandin G/H synthase 1	B	5.97	pIC50	1060	nM	IC50	Bioorg. Med. Chem. Lett. (2004) 14: 667-671 [PMID:14741265]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL	Inhibition of human recombinant COX-2 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysis	B	4.1	pIC50	80000	nM	IC50	Bioorg. Med. Chem. (2011) 19: 5372-5382 [PMID:21873070]
ChEMBL	Inhibition of human recombinant COX2 after 5 mins	B	4.1	pIC50	80000	nM	IC50	J. Med. Chem. (2010) 53: 4691-4700 [PMID:20503989]
ChEMBL	Inhibition of human COX2 pre-incubated for 10 mins before substrate addition by enzyme immunoassay	B	4.44	pIC50	36000	nM	IC50	J. Med. Chem. (2012) 55: 8807-8826 [PMID:23043222]
ChEMBL	Inhibitory activity against prostaglandin G/H synthase 2 (COX-2)	B	4.52	pIC50	30000	nM	IC50	J. Med. Chem. (1998) 41: 3515-3529 [PMID:9719605]
ChEMBL	Concentration (in uM) to inhibit 50% of Prostaglandin G/H synthase 2 (COX-2) and is expressed in IC50.	B	4.52	pIC50	30000	nM	IC50	J. Med. Chem. (1998) 41: 1112-1123 [PMID:9544211]
ChEMBL	Inhibition of Prostaglandin G/H synthase 2 (COX-2).	B	4.52	pIC50	30000	nM	IC50	J. Med. Chem. (1998) 41: 1124-1137 [PMID:9544212]
ChEMBL	Inhibition of human recombinant COX-2 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins prior to substrate challenge for 2 mins by enzyme immunoassay	B	4.52	pIC50	30000	nM	IC50	Bioorg. Med. Chem. Lett. (2014) 24: 1958-1962 [PMID:24656662]
ChEMBL	DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid)	B	4.59	pIC50	25530	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibition of COX2 (unknown origin)	B	4.84	pIC50	14500	nM	IC50	Eur J Med Chem (2017) 138: 1002-1033 [PMID:28759875]
ChEMBL	Inhibition of recombinant human COX2 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluorescence based enzyme immunoassay	B	5.05	pIC50	8910	nM	IC50	Eur J Med Chem (2019) 180: 86-98 [PMID:31301566]
ChEMBL	Tested for inhibitory activity against Prostaglandin G/H synthase 2 from human	B	5.1	pIC50	8000	nM	IC50	J. Med. Chem. (1995) 38: 3895-3901 [PMID:7562922]
ChEMBL	Inhibition of COX2 in human whole blood after 15 mins	B	5.21	pIC50	6200	nM	IC50	Bioorg. Med. Chem. (2007) 15: 4876-4890 [PMID:17517512]
ChEMBL	Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate measured after 10 mins by fluorometric based multimode microplate reader	B	5.27	pIC50	5326	nM	IC50	Eur J Med Chem (2021) 209: 112918-112918 [PMID:33071054]
ChEMBL	Inhibition of human recombinant COX2 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver esterase by fluorescence assay	B	5.37	pIC50	4300	nM	IC50	ACS Med. Chem. Lett. (2014) 5: 983-988 [PMID:25221653]
ChEMBL	Inhibition of human recombinant COX2 assessed as reduction in PGE2 formation pre-incubated for 5 mins before arachidonic acid addition and measured after 20 mins by ELISA	B	5.38	pIC50	4200	nM	IC50	J Nat Prod (2017) 80: 999-1006 [PMID:28322565]
ChEMBL	Inhibition of human recombinant COX-2 assessed as reduction in PGE2 production using 10 uM arachidonic acid as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured after 20 mins by ELISA	B	5.48	pIC50	3300	nM	IC50	ACS Med Chem Lett (2021) 12: 610-616 [PMID:33854702]
ChEMBL	Inhibition of human recombinant COX2 expressed in Sf9 cells using arachidonic acid and ADHP incubated for 5 mins by fluorimetry	B	5.48	pIC50	3300	nM	IC50	J Med Chem (2020) 63: 12614-12622 [PMID:32931274]
ChEMBL	Inhibition of human recombinant COX2 assessed as reduction in PGE2 production using arachidonic acid substrate by ELISA	B	5.7	pIC50	2000	nM	IC50	J Nat Prod (2019) 82: 1839-1848 [PMID:31268709]
ChEMBL	Inhibition of human recombinant COX-2	B	5.85	pIC50	1400	nM	IC50	J. Med. Chem. (2011) 54: 1356-1364 [PMID:21280601]
ChEMBL	Inhibition of human COX2 expressed in baculovirus system	B	5.87	pIC50	1350	nM	IC50	J. Med. Chem. (2011) 54: 8555-8562 [PMID:22091869]
GtoPdb	-	-	5.87	pIC50	1350	nM	IC50	J Med Chem (2011) 54: 8555-62 [PMID:22091869]
ChEMBL	Inhibition of human recombinant COX2 by enzyme immuno assay	B	5.96	pIC50	1100	nM	IC50	Bioorg. Med. Chem. Lett. (2016) 26: 406-412 [PMID:26691756]
ChEMBL	Inhibition of human recombinant COX2 by enzyme immunoassay	B	5.96	pIC50	1100	nM	IC50	Bioorg. Med. Chem. (2009) 17: 5182-5188 [PMID:19500994]
ChEMBL	Inhibition of human recombinant COX-2 by enzyme immuno assay	B	5.96	pIC50	1100	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 6855-6861 [PMID:19884005]
ChEMBL	Inhibition of human recombinant COX2 by enzyme immuno assay	B	5.96	pIC50	1100	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 3951-3956 [PMID:21641217]
ChEMBL	Inhibition of human COX2 by enzyme immunoassay	B	5.96	pIC50	1100	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 4544-4549 [PMID:20576432]
ChEMBL	Inhibition of human recombinant COX2	B	5.96	pIC50	1100	nM	IC50	J. Med. Chem. (2012) 55: 688-696 [PMID:22148253]
ChEMBL	Inhibition of human recombinant COX2 by enzyme immuno assay	B	5.96	pIC50	1100	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 2168-2173 [PMID:20202839]
ChEMBL	Inhibition of human recombinant COX2	B	5.96	pIC50	1100	nM	IC50	Bioorg. Med. Chem. Lett. (2013) 23: 163-168 [PMID:23200247]
ChEMBL	Inhibition of human recombinant COX2 by enzyme immunoassay	B	5.96	pIC50	1100	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 1324-1329 [PMID:20097072]
ChEMBL	Inhibition of recombinant human COX-2 preincubated for 15 mins by fluorescence analysis	B	5.96	pIC50	1100	nM	IC50	ACS Med. Chem. Lett. (2015) 6: 1086-1090 [PMID:26487917]
ChEMBL	Inhibition of recombinant human N-terminal His-tagged COX2 expressed in baculovirus infected Sf21 cells assessed as reduction in prostaglandin production by enzyme immunoassay	B	5.97	pIC50	1080	nM	IC50	Bioorg Med Chem (2018) 26: 891-902 [PMID:29373271]
ChEMBL	Inhibition activity against recombinant human Prostaglandin G/H synthase 2	B	7	pIC50	100	nM	IC50	J. Med. Chem. (1997) 40: 819-824 [PMID:9057869]
Cyclooxygenase-2 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3331] [UniProtKB: O62698]
ChEMBL	Inhibition of bovine COX2 by enzyme immunoassay	B	5.96	pIC50	1100	nM	IC50	J. Med. Chem. (2009) 52: 1525-1529 [PMID:19296694]
Cyclooxygenase-2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4102] [UniProtKB: P79208]
ChEMBL	Inhibition of sheep placental cotyledons COX2	B	5.05	pKi	9000	nM	Ki	J. Med. Chem. (2011) 54: 8555-8562 [PMID:22091869]
ChEMBL	Inhibition of ovine COX2 assessed as reduction in PGH2 production by enzyme immunoassay	B	5.85	pIC50	1400	nM	IC50	Bioorg Med Chem (2018) 26: 4113-4126 [PMID:29980364]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	5.96	pIC50	1100	nM	IC50	Bioorg. Med. Chem. (2007) 15: 4767-4774 [PMID:17509888]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	5.96	pIC50	1100	nM	IC50	Bioorg. Med. Chem. (2008) 16: 9694-9698 [PMID:18930406]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	5.96	pIC50	1100	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 584-588 [PMID:19136259]
ChEMBL	In vitro inhibitory concentration against COX-2 enzyme	B	5.96	pIC50	1100	nM	IC50	J. Med. Chem. (2005) 48: 4061-4067 [PMID:15943479]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	5.96	pIC50	1100	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 896-902 [PMID:20045320]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	5.96	pIC50	1100	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 6074-6080 [PMID:21890358]
ChEMBL	Inhibition of ovine COX2 by enzyme immunoassay	B	5.96	pIC50	1100	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 3014-3018 [PMID:19419861]
COX-2 /Cyclooxygenase-2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4321] [GtoPdb: 1376] [UniProtKB: Q05769]
ChEMBL	Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production treated prior to LPS challenge by enzyme immunoassay	B	6.07	pIC50	860	nM	IC50	Bioorg. Med. Chem. Lett. (2014) 24: 1958-1962 [PMID:24656662]
Dehydrogenase/reductase SDR family member 9 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075220] [UniProtKB: Q8VD48]
ChEMBL	Inhibition of rat liver 3-alpha-HSD assessed as 5-beta-dihydrocortisone reduction	B	4	pIC50	100000	nM	IC50	Bioorg. Med. Chem. (2007) 15: 4876-4890 [PMID:17517512]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL	Inhibition of EGFR (unknown origin) using tyrosine 4 as substrate by fluorescence analysis	B	5	pIC50	>10000	nM	IC50	ACS Med. Chem. Lett. (2015) 6: 1086-1090 [PMID:26487917]
fatty acid binding protein 1/Fatty acid-binding protein, liver in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5738] [GtoPdb: 2531] [UniProtKB: P02692]
ChEMBL	Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay	B	4.32	pKi	47600	nM	Ki	J. Med. Chem. (2008) 51: 3755-3764 [PMID:18533710]
L-PGDS/Prostaglandin-H2 D-isomerase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4334] [GtoPdb: 1380] [UniProtKB: O09114]
ChEMBL	Concentration required to inhibit 50% activity of prostaglandin synthetase was determined in vitro in mouse brain microsomes	B	4.89	pIC50	13000	nM	IC50	J. Med. Chem. (1991) 34: 1099-1110 [PMID:1900533]
Serum albumin in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3728] [UniProtKB: P02769]
ChEMBL	Binding affinity to bovine serum albumin	B	5.52	pIC50	3000	nM	IC50	Bioorg. Med. Chem. (2008) 16: 1162-1173 [PMID:18024138]
OAT6/Solute carrier family 22 member 20 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1]
ChEMBL	Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr	B	5.95	pKi	1122.02	nM	Ki	J. Biol. Chem. (2007) 282: 23841-23853 [PMID:17553798]
ChEMBL	Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr	B	5.96	pKi