rottlerin [Ligand Id: 2611] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL34241 (Rottlerin)
  • chymotrypsinogen B1/Beta-chymotrypsin in Human [ChEMBL: CHEMBL4796] [GtoPdb: 3272] [UniProtKB: P17538]
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  • Beta-lactamase in Enterobacter cloacae [ChEMBL: CHEMBL2725] [UniProtKB: P05364]
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  • Beta-lactamase AmpC in Escherichia coli [ChEMBL: CHEMBL2026] [UniProtKB: P00811]
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  • Malate dehydrogenase in Thermus thermophilus [ChEMBL: CHEMBL4255] [UniProtKB: P10584]
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  • MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
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  • MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
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  • protein kinase C delta/Protein kinase C delta in Human [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
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  • eukaryotic elongation factor 2 kinase/Serine/threonine-protein kinase EEF2K in Human [ChEMBL: CHEMBL5026] [GtoPdb: 2014] [UniProtKB: O00418]
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  • ubiquitin specific peptidase 1/Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 in Human [ChEMBL: CHEMBL3430885] [GtoPdb: 2428] [UniProtKB: O94782, Q8TAF3]
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  • Kv11.1 in Human [GtoPdb: 572] [UniProtKB: Q12809]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
chymotrypsinogen B1/Beta-chymotrypsin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4796] [GtoPdb: 3272] [UniProtKB: P17538]
ChEMBL Inhibitory activity against Chymotrypsinogen from Thermus flavus B 4.6 pIC50 25000 nM IC50 J Med Chem (2003) 46: 1478-1483 [PMID:12672248]
Beta-lactamase in Enterobacter cloacae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2725] [UniProtKB: P05364]
ChEMBL Inhibition of Enterobacter cloacae beta-lactamase incubated for 10 mins followed by nitrocefin substrate challenge and measured for 5 mins by spectrophotometric analysis B 4.02 pIC50 96000 nM IC50 ACS Med Chem Lett (2019) 10: 923-928 [PMID:31223449]
Beta-lactamase AmpC in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2026] [UniProtKB: P00811]
ChEMBL Inhibition of 30 nM AmpC beta lactamase B 4.12 pIC50 76000 nM IC50 J Med Chem (2006) 49: 7274-7277 [PMID:17149857]
ChEMBL Inhibition of 10 nM AmpC beta lactamase B 4.68 pIC50 21000 nM IC50 J Med Chem (2006) 49: 7274-7277 [PMID:17149857]
ChEMBL Inhibition of 1 nM AmpC beta lactamase B 5.74 pIC50 1800 nM IC50 J Med Chem (2006) 49: 7274-7277 [PMID:17149857]
ChEMBL Inhibitory activity against Amp C beta-Lactamase B 5.92 pIC50 1200 nM IC50 J Med Chem (2003) 46: 4265-4272 [PMID:13678405]
Malate dehydrogenase in Thermus thermophilus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4255] [UniProtKB: P10584]
ChEMBL Inhibitory activity against malate dehydrogenase (MDH) from Thermus flavus B 6.15 pIC50 700 nM IC50 J Med Chem (2003) 46: 1478-1483 [PMID:12672248]
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
ChEMBL Inhibition of His-tagged human MAPKAPK2 expressed in Escherichia coli at 10 uM B 5.27 pIC50 5400 nM IC50 Biochem J (2000) 351: 95-105 [PMID:10998351]
MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
ChEMBL Inhibition of p38-regulated activated kinase (PRAK) B 5.72 pIC50 1900 nM IC50 J Med Chem (2003) 46: 1478-1483 [PMID:12672248]
ChEMBL Inhibition of His-tagged human PRAK expressed in Sf9 cells B 5.72 pIC50 1900 nM IC50 Biochem J (2000) 351: 95-105 [PMID:10998351]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay F 5 pIC50 10000 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay F 5 pIC50 10000 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay F 5.3 pIC50 5011.87 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay F 5.4 pIC50 3981.07 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay F 5.5 pIC50 3162.28 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay F 5.5 pIC50 3162.28 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay F 5.5 pIC50 3162.28 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
GtoPdb - - 5.52 pIC50 3020 nM IC50 Biochem Biophys Res Commun (1994) 199: 93-8 [PMID:8123051]
ChEMBL Inhibition of Protein kinase C delta (PKCdelta) B 5.52 pIC50 3000 nM IC50 J Med Chem (2003) 46: 1478-1483 [PMID:12672248]
eukaryotic elongation factor 2 kinase/Serine/threonine-protein kinase EEF2K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5026] [GtoPdb: 2014] [UniProtKB: O00418]
ChEMBL Inhibition of eEF2K (unknown origin) B 5.28 pIC50 5300 nM IC50 Eur J Med Chem (2020) 204: 112505-112505 [PMID:32717479]
ubiquitin specific peptidase 1/Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3430885] [GtoPdb: 2428] [UniProtKB: O94782, Q8TAF3]
ChEMBL Inhibition of human USP1/UAF1 complex using Ub-Rho as substrate by qHTS assay B 5.1 pIC50 8000 nM IC50 J Med Chem (2016) 59: 9321-9336 [PMID:27362876]
Kv11.1 in Human [GtoPdb: 572] [UniProtKB: Q12809]
GtoPdb - - 6.5 pEC50 - - - J Pharmacol Exp Ther (2006) 319: 957-62 [PMID:16928897]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]