LY97241 [Ligand Id: 2606] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL182977 (LY-97241)
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  • Kv10.1 in Human [GtoPdb: 570] [UniProtKB: O95259]
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  • Kv10.2 in Human [GtoPdb: 571] [UniProtKB: Q8NCM2]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibitory concentration against IKr potassium channel B 8 pIC50 10 nM IC50 Bioorg Med Chem Lett (2004) 14: 4771-4777 [PMID:15324906]
ChEMBL Inhibition of human ERG B 8.66 pIC50 2.19 nM IC50 Eur J Med Chem (2011) 46: 618-630 [PMID:21185626]
Kv10.1 in Human [GtoPdb: 570] [UniProtKB: O95259]
GtoPdb - - 8.3 pIC50 - - - Br J Pharmacol (2003) 138: 161-71 [PMID:12522086]
Kv10.2 in Human [GtoPdb: 571] [UniProtKB: Q8NCM2]
GtoPdb - - 5.8 pIC50 - - - EMBO J (1997) 16: 6337-45 [PMID:9400421];
Mol Pharmacol (2004) 65: 1120-9 [PMID:15102940]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]