LY97241 [Ligand Id: 2606] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL182977 (LY-97241)
Created with Highcharts 10.3.3ValuesChart context menuHERGpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • Kv10.1 in Human [GtoPdb: 570] [UniProtKB: O95259]
Created with Highcharts 10.3.3ValuesChart context menuKv10.1pKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • Kv10.2 in Human [GtoPdb: 571] [UniProtKB: Q8NCM2]
Created with Highcharts 10.3.3ValuesChart context menuKv10.2pKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibitory concentration against IKr potassium channel B 8 pIC50 10 nM IC50 Bioorg Med Chem Lett (2004) 14: 4771-4777 [PMID:15324906]
ChEMBL Inhibition of human ERG B 8.66 pIC50 2.19 nM IC50 Eur J Med Chem (2011) 46: 618-630 [PMID:21185626]
Kv10.1 in Human [GtoPdb: 570] [UniProtKB: O95259]
GtoPdb - - 8.3 pIC50 - - - Br J Pharmacol (2003) 138: 161-71 [PMID:12522086]
Kv10.2 in Human [GtoPdb: 571] [UniProtKB: Q8NCM2]
GtoPdb - - 5.8 pIC50 - - - EMBO J (1997) 16: 6337-45 [PMID:9400421];
Mol Pharmacol (2004) 65: 1120-9 [PMID:15102940]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]