mibefradil [Ligand Id: 2522] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL45816 (Mibefradil, Posicor, Posicor 100, Posicor 50) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Cav2.2/Cacna1b/Cacnb3 in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4296086] [GtoPdb: 533] [UniProtKB: P54287, Q02294] | ||||||||
| ChEMBL | Inhibition of rat Cav2.2-alpha1beta/beta3 expressed in HEK293 cells assessed as decrease in calcium mobilization response to KCl after 1 hr by Fluo-4-AM dye-based FLIPR assay | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (2017) 60: 9769-9789 [PMID:29116786] |
| Orai1/Calcium release-activated calcium channel protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2384891] [GtoPdb: 2964] [UniProtKB: Q96D31] | ||||||||
| ChEMBL | Inhibition of Orai1-mediated store operated Ca2+ entry in human MDA-MB-231 cells assessed as reduction in BAPTA-induced Ca2+ depletion-stimulated SOCE activity preincubated for 15 mins followed by BAPTA addition in presence of extracellular Ca2+ by PBX-based FLIPR assay | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2017) 25: 440-449 [PMID:27856238] |
| ChEMBL | Inhibition of Orai1-mediated store operated Ca2+ entry in human MDA-MB-231 cells assessed as reduction of SERCA inhibition-induced ER release preincubated for 15 mins followed by CPA addition by PBX-based FLIPR assay | B | 4.28 | pIC50 | 52100 | nM | IC50 | Bioorg Med Chem (2017) 25: 440-449 [PMID:27856238] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPA | B | 6.45 | pKi | 353 | nM | Ki | J Med Chem (2007) 50: 2931-2941 [PMID:17536794] |
| ChEMBL | Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assay | B | 6.72 | pKi | 190 | nM | Ki | J Med Chem (2007) 50: 2931-2941 [PMID:17536794] |
| ChEMBL | Inhibition of human ERG expressed in CHO cells by IONWORKS assay | B | 5.48 | pIC50 | 3300 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 119-124 [PMID:23200256] |
| ChEMBL | Inhibition of hERG K channel | F | 5.74 | pIC50 | 1800 | nM | IC50 | Cardiovasc Res (2011) 91: 53-61 [PMID:21300721] |
| ChEMBL | Inhibition of human Potassium channel HERG expressed in mammalian cells | B | 5.84 | pIC50 | 1445.44 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2773-2775 [PMID:12873512] |
| ChEMBL | Inhibitory concentration against potassium channel HERG | B | 5.84 | pIC50 | 1445.44 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 2886-2890 [PMID:15911273] |
| ChEMBL | Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique | B | 5.84 | pIC50 | 1445.44 | nM | IC50 | Bioorg Med Chem (2008) 16: 6252-6260 [PMID:18448342] |
| ChEMBL | Inhibition of human ERG in MCF7 cells | B | 5.84 | pIC50 | 1445.44 | nM | IC50 | Eur J Med Chem (2009) 44: 1926-1932 [PMID:19110341] |
| ChEMBL | Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state | F | 5.84 | pIC50 | 1445.44 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1737-1741 [PMID:15745831] |
| ChEMBL | K+ channel blocking activity in COS-7 African green monkey kidney derived cells expressing HERG Kv11.1 | F | 5.84 | pIC50 | 1430 | nM | IC50 | J Med Chem (2002) 45: 3844-3853 [PMID:12190308] |
| ChEMBL | Inhibition of human ERG | B | 5.85 | pIC50 | 1400 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2705-2708 [PMID:20382529] |
| ChEMBL | Inhibitory concentration against IKr potassium channel | B | 5.85 | pIC50 | 1400 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 4771-4777 [PMID:15324906] |
| ChEMBL | Inhibition of human hERG | B | 5.85 | pIC50 | 1400 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 215-219 [PMID:21126876] |
| ChEMBL | Inhibition of human ERG | B | 5.85 | pIC50 | 1400 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1887-1890 [PMID:23395659] |
| ChEMBL | Inhibition of human ERG by whole-cell patch clamp method | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 1168-1172 [PMID:30928197] |
| ChEMBL | Inhibition of human ERG by patch clamp assay | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 5910-5915 [PMID:21843937] |
| ChEMBL | Inhibition of human ERG expressed in HEK cells by patch clamp assay | B | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 3941-3946 [PMID:26231163] |
| ChEMBL | Inhibition of human ERG | B | 6.09 | pIC50 | 806 | nM | IC50 | J Med Chem (2008) 51: 6471-6477 [PMID:18817368] |
| ChEMBL | Inhibition of human ERG | B | 6.24 | pIC50 | 580 | nM | IC50 | J Med Chem (2017) 60: 9769-9789 [PMID:29116786] |
| ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] | ||||||||
| ChEMBL | Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay | F | 5.74 | pIC50 | 1800 | nM | IC50 | J Med Chem (2003) 46: 1716-1725 [PMID:12699389] |
| ChEMBL | TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cells | F | 5.74 | pIC50 | 1800 | nM | IC50 | J Med Chem (2003) 46: 1716-1725 [PMID:12699389] |
| ChEMBL | TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cells | F | 5.8 | pIC50 | 1600 | nM | IC50 | Drug Metab Dispos (2000) 28: 895-898 [PMID:10901697] |
| ChEMBL | Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCEC | F | 5.82 | pIC50 | 1500 | nM | IC50 | J Med Chem (2003) 46: 1716-1725 [PMID:12699389] |
| ChEMBL | TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cells | F | 5.92 | pIC50 | 1200 | nM | IC50 | Mol Pharmacol (2002) 61: 964-973 [PMID:11961113] |
| P-glycoprotein 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3467] [UniProtKB: P06795] | ||||||||
| ChEMBL | Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay | F | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2003) 46: 1716-1725 [PMID:12699389] |
| ChEMBL | TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1b-expressing LLC-PK1 cells | F | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2003) 46: 1716-1725 [PMID:12699389] |
| ABCB1/P-glycoprotein 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2573] [GtoPdb: 768] [UniProtKB: P21447] | ||||||||
| ChEMBL | Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay | F | 5.13 | pIC50 | 7400 | nM | IC50 | J Med Chem (2003) 46: 1716-1725 [PMID:12699389] |
| ChEMBL | TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1a-expressing LLC-PK1 cells | F | 5.13 | pIC50 | 7400 | nM | IC50 | J Med Chem (2003) 46: 1716-1725 [PMID:12699389] |
| Plasmodium yoelii yoelii (target type: ORGANISM) [ChEMBL: CHEMBL612328] | ||||||||
| ChEMBL | Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs | F | 9.06 | pIC50 | 0.87 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 1215-1220 [PMID:18212104] |
| ChEMBL | Antimalarial activity against liver stages of Plasmodium yoelii yoelii | F | 9.06 | pIC50 | 0.87 | nM | IC50 | J Med Chem (2012) 55: 995-1012 [PMID:22122518] |
| Nav1.2/Sodium channel protein type II alpha subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399] [GtoPdb: 579] [UniProtKB: P04775] | ||||||||
| ChEMBL | Inhibition of rat brain Nav1.2 expressed in HEK293 cells by whole cell voltage clamp method | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2017) 60: 9769-9789 [PMID:29116786] |
| Nav1.4/Sodium channel protein type IV alpha subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3509] [GtoPdb: 581] [UniProtKB: P15390] | ||||||||
| ChEMBL | Inhibition of rat skeletal muscle Nav1.4 expressed in HEK293 cells by whole cell voltage clamp method | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2017) 60: 9769-9789 [PMID:29116786] |
| Nav1.7/Sodium channel protein type IX alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4296] [GtoPdb: 584] [UniProtKB: Q15858] | ||||||||
| ChEMBL | Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell voltage clamp method | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2017) 60: 9769-9789 [PMID:29116786] |
| Nav1.5/Sodium channel protein type V alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524] | ||||||||
| ChEMBL | Inhibition of human heart Nav1.5 expressed in HEK293 cells by whole cell voltage clamp method | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2017) 60: 9769-9789 [PMID:29116786] |
| Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936] | ||||||||
| GtoPdb | - | - | 4.9 | pIC50 | - | - | - | J Pharmacol Exp Ther (2000) 295: 302-8 [PMID:10991994] |
| ChEMBL | Inhibition of Cav1.2 (unknown origin) | B | 6.6 | pIC50 | 250 | nM | IC50 | J Med Chem (2017) 60: 9769-9789 [PMID:29116786] |
| ChEMBL | Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR assay | B | 6.69 | pIC50 | 202 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 3941-3946 [PMID:26231163] |
| Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002] | ||||||||
| ChEMBL | Inhibition of Cav1.2 calcium current measured using FLIPR in rat aortic A7r5 cells | F | 5.96 | pIC50 | 1100 | nM | IC50 | IC50 data for the L-type calcium channel extracted from a set of literature articles |
| Cav2.2/Voltage-gated N-type calcium channel alpha-1B subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4478] [GtoPdb: 533] [UniProtKB: Q00975] | ||||||||
| ChEMBL | Inhibition of N-type calcium channel Alpha-1B | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2705-2708 [PMID:20382529] |
| ChEMBL | Antagonist activity against L-type calcium channel subunit alpha-1C assessed as inactivation of channel current by cell based patch clamp assay | F | 6.38 | pIC50 | 416 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6375-6378 [PMID:20934333] |
| Cav3.1/Voltage-gated T-type calcium channel alpha-1G subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4641] [GtoPdb: 535] [UniProtKB: O43497] | ||||||||
| ChEMBL | Inhibition of T-type calcium channel Cav3.1 with alpha-1G subunit by patch clamp assay | B | 5.84 | pIC50 | 1430 | nM | IC50 | Bioorg Med Chem (2007) 15: 365-373 [PMID:17035033] |
| ChEMBL | Inhibition of T-type [Ca2+] channel (alpha1G) expressed in HEK293 cells | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 283-286 [PMID:15603940] |
| ChEMBL | Ability to block calcium channel T type 3.1v expressed in HEK293 cells by whole cell patch clamp method | F | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5244-5248 [PMID:16876404] |
| ChEMBL | Inhibition of T type calcium channel Cav3.1 (unknown origin) expressed in HEK293T cells by patch clamp method relative to control | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 1073-1079 [PMID:26739776] |
| ChEMBL | Inhibition of T type calcium channel subunit alpha-1G expressed in HEK293 cells assessed as effect on T-type calcium currents by patch clamp method | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem (2007) 15: 1409-1419 [PMID:17150365] |
| ChEMBL | Inhibition of T-type calcium channel Cav3.1 alpha-1G subunit expressed in HEK293 cells assessed as calcium current by patch-clamp assay | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 5740-5743 [PMID:17869104] |
| ChEMBL | Inhibition of T-type calcium channel Cav3.1 expressed in HEK293 cells co-expressing alpha1G subunit by whole-cell patch clamp method | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 471-475 [PMID:17064894] |
| ChEMBL | Inhibition of T-type calcium channel Cav3.1 expressed in HEK293 cells co-expressing alpha1G subunit and Kir2.1 potassium channel by patch-clamp assay | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 476-481 [PMID:17092715] |
| ChEMBL | Antagonist activity at T type calcium channel alpha1G expressed in HEK293 cells assessed as inhibition of peak currents by whole-cell patch-clamp method | F | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4424-4427 [PMID:18625556] |
| ChEMBL | Inhibition of T-type calcium channel alpha1G expressed in human HEK293 cells assessed as inhibition of peak currents by whole-cell patch-clamp method | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2705-2708 [PMID:20382529] |
| ChEMBL | Inhibition of human Cav3.1 expressed in tsA-201 cells by patch clamp electrophysiology | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem (2020) 28: 115491-115491 [PMID:32327350] |
| ChEMBL | Inhibition of T-type alpha1G calcium channel expressed in HEK293 cells assessed as Kcl-induced depolarization | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 215-219 [PMID:21126876] |
| ChEMBL | Inhibition of T-type alpha1G channel expressed in HEK293 cells by whole-cell patch-clamp method | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem (2010) 18: 5938-5944 [PMID:20659804] |
| ChEMBL | Inhibition of T-type Cav3.1 channel | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem (2010) 18: 5938-5944 [PMID:20659804] |
| ChEMBL | Inhibition of T-type CaV3.1 channel expressed in HEK293 cells assessed as inhibition of calcium current by manual patch-clamp assay | B | 6.07 | pIC50 | 860 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4219-4222 [PMID:20621730] |
| ChEMBL | Inhibition of alpha-1G T-type calcium channel expressed in HEK293 cells by electrophysiological method | B | 6.08 | pIC50 | 840 | nM | IC50 | Bioorg Med Chem (2007) 15: 1091-1105 [PMID:17074493] |
| ChEMBL | Concentration of the compounds required for inhibition of HEK293 cells (alpha1G T-type) | F | 6.08 | pIC50 | 840 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 3379-3384 [PMID:15177437] |
| ChEMBL | Inhibition of T-type CaV3.1 channel expressed in HEK293 cells assessed as inhibition of calcium current by automated patch-clamp assay | B | 6.08 | pIC50 | 830 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4219-4222 [PMID:20621730] |
| ChEMBL | Inhibition of alpha-1G calcium channel in human HEK293 cells by whole-cell patch-clamp method | B | 6.08 | pIC50 | 830 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1887-1890 [PMID:23395659] |
| ChEMBL | Inhibition of T-type CaV3.1 channel (unknown origin) expressed in HEK293 cells assessed as inhibition of calcium current by whole cell patch-clamp method | B | 6.25 | pIC50 | 560 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1565-1570 [PMID:24529871] |
| ChEMBL | Inhibition of t-type Cav3.1 channel (unknown origin) expressed in HEK293 cells assessed as inhibition of 50 ms depolarizing voltage step-induced current by whole cell patch-clamp method | B | 6.25 | pIC50 | 560 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 6656-6662 [PMID:24220170] |
| GtoPdb | - | - | 6.6 | pIC50 | 270 | nM | IC50 | J Pharmacol Exp Ther (2000) 295: 302-8 [PMID:10991994] |
| ChEMBL | Inhibition of human Cav3.1 alpha1G expressed in HEK293 cells assessed as inhibition of calcium influx by FLIPR assay | B | 6.7 | pIC50 | 200 | nM | IC50 | Bioorg Med Chem (2011) 19: 5628-5638 [PMID:21875808] |
| ChEMBL | Inhibition of Cav3.1 (unknown origin) | B | 7.19 | pIC50 | 64 | nM | IC50 | J Med Chem (2017) 60: 9769-9789 [PMID:29116786] |
| Cav3.2/Voltage-gated T-type calcium channel alpha-1H subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1859] [GtoPdb: 536] [UniProtKB: O95180] | ||||||||
| ChEMBL | Inhibition of T-type Cav3.2 channel | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem (2010) 18: 5938-5944 [PMID:20659804] |
| ChEMBL | Inhibition of human T-type calcium channel Cav3.2 expressed in T-Rex293 cells by whole cell patch clamp assay | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 119-124 [PMID:23200256] |
| ChEMBL | Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR assay | B | 6.74 | pIC50 | 181 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 3941-3946 [PMID:26231163] |
| ChEMBL | Antagonist activity at human alpha1H T-type calcium channel expressed in HEK293 cells by patch clamp technique | F | 6.89 | pIC50 | 130 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 474-478 [PMID:18160281] |
| ChEMBL | Inhibition of Cav3.2 (unknown origin) | B | 6.89 | pIC50 | 130 | nM | IC50 | J Med Chem (2017) 60: 9769-9789 [PMID:29116786] |
| GtoPdb | - | - | 7.2 | pIC50 | 69 | nM | IC50 | J Pharmacol Exp Ther (2000) 295: 302-8 [PMID:10991994] |
| ChEMBL | Antagonist activity against T-type calcium channel subunit alpha-1H assessed as inactivation of channel current by cell based patch clamp assay | F | 7.49 | pIC50 | 32 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6375-6378 [PMID:20934333] |
| Cav3.3/Voltage-gated T-type calcium channel alpha-1I subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5558] [GtoPdb: 537] [UniProtKB: Q9P0X4] | ||||||||
| GtoPdb | - | - | 5.8 | pIC50 | 1500 | nM | IC50 | J Pharmacol Exp Ther (2000) 295: 302-8 [PMID:10991994] |
| ChEMBL | Inhibition of T-type Cav3.3 channel | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem (2010) 18: 5938-5944 [PMID:20659804] |
| ChEMBL | Inhibition of Cav3.3 (unknown origin) | B | 6.89 | pIC50 | 130 | nM | IC50 | J Med Chem (2017) 60: 9769-9789 [PMID:29116786] |
| ChEMBL | Inhibition of T-type calcium channel alpha1I by FLIPR | B | 6.9 | pIC50 | 126 | nM | IC50 | J Med Chem (2008) 51: 6471-6477 [PMID:18817368] |
| CatSper1 in Human [GtoPdb: 388] [UniProtKB: Q8NEC5] | ||||||||
| GtoPdb | Patch clamp electrophysiology, kinetic rapid mixing fluometry | - | 4.5 | pIC50 | 30000 | nM | IC50 | Nature (2011) 471: 382-6 [PMID:21412338] |
| CatSper2 in Human [GtoPdb: 389] [UniProtKB: Q96P56] | ||||||||
| GtoPdb | Patch clamp electrophysiology and kinetic rapid mixing fluometry. | - | 4.5 | pIC50 | 30000 | nM | IC50 | Nature (2011) 471: 382-6 [PMID:21412338] |
| CatSper3 in Human [GtoPdb: 390] [UniProtKB: Q86XQ3] | ||||||||
| GtoPdb | Patch clamp electrophysiology, kinetic rapid mixing fluometry. | - | 4.5 | pIC50 | 30000 | nM | IC50 | Nature (2011) 471: 382-6 [PMID:21412338] |
| CatSper4 in Human [GtoPdb: 391] [UniProtKB: Q7RTX7] | ||||||||
| GtoPdb | Patch clamp electrophysiology, kinetic rapid mixing fluometry. | - | 4.5 | pIC50 | 30000 | nM | IC50 | Nature (2011) 471: 382-6 [PMID:21412338] |
| Cav2.1 in Rat [GtoPdb: 532] [UniProtKB: P54282] | ||||||||
| GtoPdb | - | - | 6.5 | pIC50 | - | - | - | Neuropharmacology (2000) 39: 1-10 [PMID:10665814] |
| Cav2.3 in Rat [GtoPdb: 534] [UniProtKB: Q07652] | ||||||||
| GtoPdb | - | - | 6.4 | pIC50 | - | - | - | Neuropharmacology (2000) 39: 1-10 [PMID:10665814] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
