[3H](+)-cis-diltiazem [Ligand Id: 2512] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL603584 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG | B | 4.76 | pIC50 | 17378.01 | nM | IC50 | Eur J Med Chem (2011) 46: 618-630 [PMID:21185626] |
| Cav1.1 in Rabbit [GtoPdb: 528] | ||||||||
| GtoPdb | - | - | 7.4 | pKd | - | - | - |
J Biol Chem (1993) 268: 18580-5 [PMID:8395510]; J Pharmacol Exp Ther (1997) 281: 173-9 [PMID:9103495] |
| Cav1.2 in Rat [GtoPdb: 529] [UniProtKB: P22002] | ||||||||
| GtoPdb | - | - | 7.2 | pKd | - | - | - | J Pharmacol Exp Ther (1990) 255: 600-7 [PMID:2147036] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
