PPAHV [Ligand Id: 2490] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL104647 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TRPV1/Vanilloid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4794] [GtoPdb: 507] [UniProtKB: Q8NER1] | ||||||||
| ChEMBL | Inhibition of [3H]- RTX binding to Vanilloid receptors from human spinal cord | B | 5.19 | pKi | 6400 | nM | Ki | J Med Chem (1996) 39: 3123-3131 [PMID:8759633] |
| ChEMBL | Inhibition of [3H]- RTX binding to Vanilloid receptors from pig spinal cord | B | 5.68 | pKi | 2100 | nM | Ki | J Med Chem (1996) 39: 3123-3131 [PMID:8759633] |
| ChEMBL | Inhibitory constant for RTX binding to human spinal cord | F | 9.35 | pKi | 0.45 | nM | Ki | J Med Chem (1996) 39: 3123-3131 [PMID:8759633] |
| ChEMBL | Inhibitory constant for RTX binding to porcine spinal cord | F | 9.92 | pKi | 0.12 | nM | Ki | J Med Chem (1996) 39: 3123-3131 [PMID:8759633] |
| TRPV1/Vanilloid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5102] [GtoPdb: 507] [UniProtKB: O35433] | ||||||||
| ChEMBL | Inhibition of [3H]- RTX binding to vanilloid receptor of rat urinary bladder | F | 5.7 | pKi | 2000 | nM | Ki | J Med Chem (1996) 39: 3123-3131 [PMID:8759633] |
| ChEMBL | Displacement of [3H]RTX binding from Vanilloid receptor of rat dorsal Root Ganglion (DRG) membranes | B | 6.22 | pKi | 600 | nM | Ki | J Med Chem (1996) 39: 3123-3131 [PMID:8759633] |
| ChEMBL | Inhibitory constant for RTX binding to rat spinal cord | F | 10.27 | pKi | 0.05 | nM | Ki | J Med Chem (1996) 39: 3123-3131 [PMID:8759633] |
| GtoPdb | - | - | 5.5 | pEC50 | - | - | - | Br J Pharmacol (2001) 132: 1084-94 [PMID:11226139] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
