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ChEMBL ligand: CHEMBL67166 (D-Sphingosine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3390] [GtoPdb: 1476] [UniProtKB: P27791] | ||||||||
ChEMBL | Inhibition of cAMP-dependent kinase PKA(Protein kinase A) catalytic subunit at 100 uM | B | 7.01 | pIC50 | 98 | nM | IC50 | J Med Chem (1991) 34: 2928-2931 [PMID:1895309] |
cholesteryl ester transfer protein/Cholesteryl ester transfer protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3572] [GtoPdb: 3248] [UniProtKB: P11597] | ||||||||
ChEMBL | Compound was measured for its inhibitory activity against cholesteryl ester transfer protein (CETP) | B | 4.94 | pIC50 | 11500 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 1481-1482 |
sphingosine kinase 1/Sphingosine kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4394] [GtoPdb: 2204] [UniProtKB: Q9NYA1] | ||||||||
ChEMBL | Inhibition of SphK1 | B | 5.41 | pIC50 | 3860 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3382-3385 [PMID:19467599] |
sphingosine kinase 2/Sphingosine kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3023] [GtoPdb: 2205] [UniProtKB: Q9NRA0] | ||||||||
ChEMBL | Inhibition of SphK2 | B | 5.81 | pIC50 | 1560 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3382-3385 [PMID:19467599] |
TRPM3 in Human [GtoPdb: 495] [UniProtKB: Q9HCF6] | ||||||||
GtoPdb | - | - | 4.9 | pEC50 | 12589 | nM | EC50 | Mol Pharmacol (2005) 67: 798-805 [PMID:15550678] |
TRPM7 in Mouse [GtoPdb: 499] [UniProtKB: Q923J1] | ||||||||
GtoPdb | - | - | 6.23 | pIC50 | 590 | nM | IC50 | Br J Pharmacol (2013) 168: 1294-312 [PMID:23145923] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]