ChEMBL ligand: CHEMBL67166 (D-Sphingosine)
protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Rat [ChEMBL: CHEMBL3390] [GtoPdb: 1476] [UniProtKB: P27791] There should be some charts here, you may need to enable JavaScript!
cholesteryl ester transfer protein/Cholesteryl ester transfer protein in Human [ChEMBL: CHEMBL3572] [GtoPdb: 3248] [UniProtKB: P11597] There should be some charts here, you may need to enable JavaScript!
sphingosine kinase 1/Sphingosine kinase 1 in Human [ChEMBL: CHEMBL4394] [GtoPdb: 2204] [UniProtKB: Q9NYA1] There should be some charts here, you may need to enable JavaScript!
sphingosine kinase 2/Sphingosine kinase 2 in Human [ChEMBL: CHEMBL3023] [GtoPdb: 2205] [UniProtKB: Q9NRA0] There should be some charts here, you may need to enable JavaScript!
TRPM3 in Human [GtoPdb: 495] [UniProtKB: Q9HCF6] There should be some charts here, you may need to enable JavaScript!
TRPM7 in Mouse [GtoPdb: 499] [UniProtKB: Q923J1] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3390] [GtoPdb: 1476] [UniProtKB: P27791]
ChEMBL	Inhibition of cAMP-dependent kinase PKA(Protein kinase A) catalytic subunit at 100 uM	B	7.01	pIC50	98	nM	IC50	J Med Chem (1991) 34: 2928-2931 [PMID:1895309]
cholesteryl ester transfer protein/Cholesteryl ester transfer protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3572] [GtoPdb: 3248] [UniProtKB: P11597]
ChEMBL	Compound was measured for its inhibitory activity against cholesteryl ester transfer protein (CETP)	B	4.94	pIC50	11500	nM	IC50	Bioorg Med Chem Lett (1997) 7: 1481-1482
sphingosine kinase 1/Sphingosine kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4394] [GtoPdb: 2204] [UniProtKB: Q9NYA1]
ChEMBL	Inhibition of SphK1	B	5.41	pIC50	3860	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3382-3385 [PMID:19467599]
sphingosine kinase 2/Sphingosine kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3023] [GtoPdb: 2205] [UniProtKB: Q9NRA0]
ChEMBL	Inhibition of SphK2	B	5.81	pIC50	1560	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3382-3385 [PMID:19467599]
TRPM3 in Human [GtoPdb: 495] [UniProtKB: Q9HCF6]
GtoPdb	-	-	4.9	pEC50	12589	nM	EC50	Mol Pharmacol (2005) 67: 798-805 [PMID:15550678]
TRPM7 in Mouse [GtoPdb: 499] [UniProtKB: Q923J1]
GtoPdb	-	-	6.23	pIC50	590	nM	IC50	Br J Pharmacol (2013) 168: 1294-312 [PMID:23145923]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]