ChEMBL ligand: CHEMBL181 (Diazoxide, Diazoxidum, Eudemine, Eudemine injection, Eudimine, Hyperstat, Hypertonalum, Mutabase, NSC-64198, NSC-76130, Proglycem, SCH 6783, SCH-6783, SRG 95213, SRG-95213)
Nicotinamide phosphoribosyltransferase in Human [ChEMBL: CHEMBL1744525] [UniProtKB: P43490] There should be some charts here, you may need to enable JavaScript!
ATP-binding cassette, sub-family C (CFTR/MRP), member 8/Kir6.2/Sulfonylurea receptor 1, Kir6.2 in Human [ChEMBL: CHEMBL2096972] [GtoPdb: 2594, 442] [UniProtKB: Q09428, Q14654] ATP-binding cassette, sub-family C (CFTR/MRP), member 8/Kir6.2 in Mouse [GtoPdb: 2594, 442] [UniProtKB: Q61743] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Nicotinamide phosphoribosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1744525] [UniProtKB: P43490]
ChEMBL	Binding affinity to NAMPT (2 to 491) (unknown origin) by surface plasmon resonance analysis	B	3.64	pKd	230000	nM	Kd	J Med Chem (2014) 57: 770-792 [PMID:24405419]
ATP-binding cassette, sub-family C (CFTR/MRP), member 8/Kir6.2/Sulfonylurea receptor 1, Kir6.2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096972] [GtoPdb: 2594, 442] [UniProtKB: Q09428, Q14654]
ChEMBL	Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarization	B	4.48	pEC50	33000	nM	EC50	J Med Chem (2007) 50: 2117-2126 [PMID:17425298]
ChEMBL	Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channels	F	4.48	pEC50	33000	nM	EC50	J Med Chem (2006) 49: 4127-4139 [PMID:16821773]
ChEMBL	Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as activation of K+ currents	B	4.51	pEC50	31000	nM	EC50	J Med Chem (2007) 50: 2117-2126 [PMID:17425298]
ChEMBL	Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assay	B	4.52	pEC50	30000	nM	EC50	Bioorg Med Chem Lett (2023) 87: 129256-129256 [PMID:36966977]
ChEMBL	Activation of human recombinant SUR1/Kir6.2 channel expressed in HEK293 cells assessed as increase in ionic current by whole cell patch clamp assay	B	4.63	pEC50	23500	nM	EC50	J Med Chem (2010) 53: 147-154 [PMID:19919106]
ChEMBL	Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes	F	5.06	pEC50	8800	nM	EC50	Bioorg Med Chem Lett (2004) 14: 813-816 [PMID:14741296]
ChEMBL	Inhibition of Beta-cell KATP channel	F	5.06	pEC50	8800	nM	EC50	Bioorg Med Chem Lett (2002) 12: 2977-2980 [PMID:12270187]
ATP-binding cassette, sub-family C (CFTR/MRP), member 8/Kir6.2 in Mouse [GtoPdb: 2594, 442] [UniProtKB: Q61743]
GtoPdb	-	-	4.2	pEC50	63000	nM	EC50	Science (1995) 270: 1166-70 [PMID:7502040]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]