ChEMBL ligand: CHEMBL510780 (NS-8593)
histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] There should be some charts here, you may need to enable JavaScript!
KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Human [ChEMBL: CHEMBL3381] [GtoPdb: 383] [UniProtKB: Q9UGI6] KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Rat [ChEMBL: CHEMBL3780] [GtoPdb: 383] [UniProtKB: P70605] There should be some charts here, you may need to enable JavaScript!
TRPM7/Transient receptor potential cation channel subfamily M member 7 in Mouse [ChEMBL: CHEMBL3714706] [GtoPdb: 499] [UniProtKB: Q923J1] There should be some charts here, you may need to enable JavaScript!
KCa2.1 in Human [GtoPdb: 381] [UniProtKB: Q92952] There should be some charts here, you may need to enable JavaScript!
KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
ChEMBL	Determination of IC50 values for inhibition of enzymatic assay of human HDAC6 with custom peptide substrate	B	5.86	pIC50	1393	nM	IC50	HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators
KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3381] [GtoPdb: 383] [UniProtKB: Q9UGI6]
ChEMBL	Inhibition of wild type human SK3 channel expressed in HEK293 cells	B	7	pKd	100	nM	Kd	J Med Chem (2008) 51: 7625-7634 [PMID:18998663]
GtoPdb	-	-	6.1	pIC50	-	-	-	Mol Pharmacol (2006) 70: 1771-82 [PMID:16926279]
ChEMBL	Inhibition of wild type human SK3 channel expressed in HEK293 cells assessed as Ca2+ sensitivity by inside-out patch clamp technique in presence of 500 nM Ca2+	B	5.66	pEC50	2200	nM	EC50	J Med Chem (2008) 51: 7625-7634 [PMID:18998663]
ChEMBL	Inhibition of wild type human SK3 channel expressed in HEK293 cells assessed as Ca2+ sensitivity by inside-out patch clamp technique	B	6.4	pEC50	400	nM	EC50	J Med Chem (2008) 51: 7625-7634 [PMID:18998663]
KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3780] [GtoPdb: 383] [UniProtKB: P70605]
ChEMBL	Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique	B	7.11	pKd	77	nM	Kd	J Med Chem (2008) 51: 7625-7634 [PMID:18998663]
ChEMBL	Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells	B	4.3	pKi	>50000	nM	Ki	J Med Chem (2008) 51: 7625-7634 [PMID:18998663]
TRPM7/Transient receptor potential cation channel subfamily M member 7 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3714706] [GtoPdb: 499] [UniProtKB: Q923J1]
ChEMBL	Inhibition of mouse TRPM7 transfected in HEK293 cells assessed as inhibition of channel current in presence of 300 uM free intracellular Mg2+ by whole cell patch clamp analysis	B	5.23	pIC50	5900	nM	IC50	J Nat Prod (2024) 87: 783-797 [PMID:38537009]
ChEMBL	Inhibition of mouse TRPM7 transfected in HEK293 cells assessed as inhibition of channel current in presence of 780 uM free intracellular Mg2+ by whole cell patch clamp analysis	B	5.41	pIC50	3900	nM	IC50	J Nat Prod (2024) 87: 783-797 [PMID:38537009]
ChEMBL	Inhibition of mouse TRPM7 transfected in HEK293 cells assessed as inhibition of channel current in absence of intracellular Mg2+ by whole cell patch clamp analysis	B	5.8	pIC50	1600	nM	IC50	J Nat Prod (2024) 87: 783-797 [PMID:38537009]
GtoPdb	-	-	5.8	pIC50	1600	nM	IC50	Br J Pharmacol (2012) 166: 1357-76 [PMID:22242975]
KCa2.1 in Human [GtoPdb: 381] [UniProtKB: Q92952]
GtoPdb	-	-	6.4	pIC50	400	nM	IC50	Mol Pharmacol (2006) 70: 1771-82 [PMID:16926279]
KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1]
GtoPdb	-	-	6.2	pIC50	-	-	-	Mol Pharmacol (2006) 70: 1771-82 [PMID:16926279]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]