5-hydroxyindole [Ligand Id: 2295] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL404923 (5-Hydroxyindole) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DNA repair protein RAD51 homolog 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034807] [UniProtKB: Q06609] | ||||||||
| ChEMBL | Binding affinity to RAD51 (unknown origin) by isothermal calorimetry | B | 2.68 | pKd | 2100000 | nM | Kd | Bioorg Med Chem Lett (2015) 25: 2461-2468 [PMID:25971770] |
| Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960] | ||||||||
| ChEMBL | Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupole mass spectrometry | B | 2.7 | pIC50 | >2000000 | nM | IC50 | J Med Chem (2009) 52: 4694-4715 [PMID:19618939] |
| ChEMBL | Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE | B | 3 | pIC50 | >1000000 | nM | IC50 | J Med Chem (2009) 52: 4694-4715 [PMID:19618939] |
| tyrosinase/Tyrosinase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5346] [GtoPdb: 2643] [UniProtKB: P11344] | ||||||||
| ChEMBL | Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation | B | 4.17 | pIC50 | 68000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 4178-4182 [PMID:19524439] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
