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tyrosinase

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Target id: 2643

Nomenclature: tyrosinase

Family: 1.-.-.- Oxidoreductases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 529 11q14.3 TYR tyrosinase
Mouse 1 533 7 49.01 cM Tyr tyrosinase
Rat - 530 1q32 Tyr tyrosinase
Previous and Unofficial Names Click here for help
OCA1A | OCAIA
Database Links Click here for help
Alphafold P14679 (Hs), P11344 (Mm)
BRENDA 1.14.18.1
CATH/Gene3D 1.10.1280.10
ChEMBL Target CHEMBL1973 (Hs), CHEMBL5346 (Mm)
DrugBank Target P14679 (Hs)
Ensembl Gene ENSG00000077498 (Hs), ENSMUSG00000004651 (Mm), ENSRNOG00000016421 (Rn)
Entrez Gene 7299 (Hs), 22173 (Mm), 308800 (Rn)
Human Protein Atlas ENSG00000077498 (Hs)
KEGG Enzyme 1.14.18.1
KEGG Gene hsa:7299 (Hs), mmu:22173 (Mm), rno:308800 (Rn)
OMIM 606933 (Hs)
Orphanet ORPHA120353 (Hs)
Pharos P14679 (Hs)
RefSeq Nucleotide NM_000372 (Hs), NM_011661 (Mm), NM_001107535 (Rn)
RefSeq Protein NP_000363 (Hs), NP_035791 (Mm), NP_001101005 (Rn)
UniProtKB P14679 (Hs), P11344 (Mm)
Wikipedia TYR (Hs)
Enzyme Reaction Click here for help
EC Number: 1.14.18.1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 7 [PMID: 21334791] Small molecule or natural product ? Inhibition 6.4 pIC50 1
⤷ pIC50 6.4 (IC50 3.7x10-7 M) [1]
Immuno Process Associations
Immuno Process:  Immune system development
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Melanoma, cutaneous malignant, susceptibility to, 8; CMM8
OMIM: 601800
Disease:  Minimal pigment oculocutaneous albinism type 1
Orphanet: ORPHA352734
Disease:  Ocular albinism with congenital sensorineural deafness
OMIM: 103470
Orphanet: ORPHA352740
Disease:  Oculocutaneous albinism type 1A
Synonyms: Oculocutaneous albinism [Disease Ontology: DOID:0050632]
Disease Ontology: DOID:0050632
OMIM: 203100
Orphanet: ORPHA79431
Disease:  Oculocutaneous albinism type 1B
Synonyms: Oculocutaneous albinism [Disease Ontology: DOID:0050632]
Disease Ontology: DOID:0050632
OMIM: 606952
Orphanet: ORPHA79434
Disease:  Temperature-sensitive oculocutaneous albinism type 1
OMIM: 606952
Orphanet: ORPHA352737

References

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1. Tajima R, Oozeki H, Muraoka S, Tanaka S, Motegi Y, Nihei H, Yamada Y, Masuoka N, Nihei K. (2011) Synthesis and evaluation of bibenzyl glycosides as potent tyrosinase inhibitors. Eur J Med Chem, 46 (4): 1374-81. [PMID:21334791]

How to cite this page

1.-.-.- Oxidoreductases: tyrosinase. Last modified on 16/09/2015. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2643.