tubocurarine [Ligand Id: 2294] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL339427 (D-tubocurarine, Tubocurarine, Tubocurarine cation, Tubocurarine ion)
  • Multidrug and toxin extrusion/Multidrug and toxin extrusion protein 1 in Human [ChEMBL: CHEMBL1743126] [GtoPdb: 1216] [UniProtKB: Q96FL8]
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  • MATE2/Multidrug and toxin extrusion protein 2 in Human [ChEMBL: CHEMBL1743127] [GtoPdb: 1217] [UniProtKB: Q86VL8]
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  • Nicotinic acetylcholine receptor alpha 5 subunit in Musca domestica [ChEMBL: CHEMBL2366408] [UniProtKB: A9XFY4]
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  • Organic cation transporter 2/Solute carrier family 22 member 2 in Human [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244]
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  • 5-HT3AB in Human [GtoPdb: 378]
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  • 5-HT3A in Human [GtoPdb: 379]
  • 5-HT3A in Mouse [GtoPdb: 379]
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  • KCa2.1 in Human [GtoPdb: 381] [UniProtKB: Q92952]
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  • KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1]
  • KCa2.2 in Rat [GtoPdb: 382] [UniProtKB: P70604]
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  • KCa2.3 in Human [GtoPdb: 383] [UniProtKB: Q9UGI6]
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  • ZAC in Human [GtoPdb: 587] [UniProtKB: Q401N2]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Multidrug and toxin extrusion/Multidrug and toxin extrusion protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743126] [GtoPdb: 1216] [UniProtKB: Q96FL8]
ChEMBL Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay B 5.03 pIC50 9400 nM IC50 J Med Chem (2013) 56: 781-795 [PMID:23241029]
MATE2/Multidrug and toxin extrusion protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743127] [GtoPdb: 1217] [UniProtKB: Q86VL8]
ChEMBL Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay B 4.26 pIC50 55500 nM IC50 J Med Chem (2013) 56: 781-795 [PMID:23241029]
Nicotinic acetylcholine receptor alpha 5 subunit in Musca domestica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366408] [UniProtKB: A9XFY4]
ChEMBL Displacement of [3H]alpha-bungarotoxin from nAChR in Musca domestica (house fly) head membrane after 60 min by scintillation counting B 5.73 pKi 1880 nM Ki J Pestic Sci (1992) 17: 231-236
Organic cation transporter 2/Solute carrier family 22 member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244]
ChEMBL Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay B 4.1 pIC50 78800 nM IC50 J Med Chem (2013) 56: 781-795 [PMID:23241029]
5-HT3AB in Human [GtoPdb: 378]
GtoPdb - - 4.5 pKi - - - Neuropharmacology (2001) 41: 282-4 [PMID:11489465]
5-HT3A in Human [GtoPdb: 379]
GtoPdb - - 4.8 pKi - - - Neuropharmacology (2001) 41: 282-4 [PMID:11489465];
Br J Pharmacol (1996) 118: 1237-45 [PMID:8818349]
5-HT3A in Mouse [GtoPdb: 379]
GtoPdb - - 7.1 pKi - - - J Neurochem (1995) 65: 104-10 [PMID:7790853];
Neuropharmacology (1998) 37: 251-7 [PMID:9680250]
KCa2.1 in Human [GtoPdb: 381] [UniProtKB: Q92952]
GtoPdb - - 4.6 pIC50 25000 nM IC50 Science (1996) 273: 1709-14 [PMID:8781233];
Br J Pharmacol (2000) 129: 627-30 [PMID:10683185];
Br J Pharmacol (2000) 129: 991-9 [PMID:10696100]
KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1]
GtoPdb - - 5.7 pIC50 - - - FEBS Lett (2000) 469: 196-202 [PMID:10713270]
KCa2.2 in Rat [GtoPdb: 382] [UniProtKB: P70604]
GtoPdb - - 5.6 pIC50 - - - Science (1996) 273: 1709-14 [PMID:8781233];
Br J Pharmacol (2000) 129: 991-9 [PMID:10696100];
J Biol Chem (1997) 272: 23195-200 [PMID:9287325]
KCa2.3 in Human [GtoPdb: 383] [UniProtKB: Q9UGI6]
GtoPdb - - 4.5 pIC50 - - - Neuropharmacology (2001) 40: 772-83 [PMID:11369031];
Mol Pharmacol (2004) 65: 788-801 [PMID:14978258]
ZAC in Human [GtoPdb: 587] [UniProtKB: Q401N2]
GtoPdb - - 5.2 pIC50 6300 nM IC50 J Biol Chem (2003) 278: 712-7 [PMID:12381728]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]