UDP [Ligand Id: 1749] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL130266 (UDP, Uridine 5'-Diphosphate, Uridine-5'-Diphosphate, Uridine Diphosphate) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| P2Y14 receptor in Human [GtoPdb: 330] [UniProtKB: Q15391] | ||||||||
| GtoPdb | - | - | 7.13 | pEC50 | 74 | nM | EC50 | Mol Pharmacol (2009) 76: 1341-8 [PMID:19759354] |
| P2Y14 receptor/P2Y purinoceptor 14 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295660] [GtoPdb: 330] [UniProtKB: O35881] | ||||||||
| GtoPdb | - | - | 6.5 | pIC50 | - | - | - | J Pharmacol Exp Ther (2008) 325: 588-94 [PMID:18252808] |
| ChEMBL | Antagonist activity at rat P2Y14 | B | 6.46 | pEC50 | 350 | nM | EC50 | J Med Chem (2016) 59: 9981-10005 [PMID:27413802] |
| P2Y1 receptor/Purinergic receptor P2Y1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4315] [GtoPdb: 323] [UniProtKB: P47900] | ||||||||
| ChEMBL | Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of human erythrocytes | F | 4 | pEC50 | >100000 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
| P2Y14 receptor/Purinergic receptor P2Y14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4518] [GtoPdb: 330] [UniProtKB: Q15391] | ||||||||
| ChEMBL | Agonist activity at recombinant human P2Y14 receptor expressed in African green monkey COS7 cells co-transfected with Galphaqi assessed as stimulation of phospholipase Cbeta | B | 3.8 | pEC50 | 160000 | nM | EC50 | Bioorg Med Chem (2015) 23: 4056-4064 [PMID:25868749] |
| ChEMBL | Agonist activity at human P2Y14 receptor expressed in HEK293 cells coexpressing phospholipase C-activating Gi protein cells assessed as inhibition of forskolin induced [3H]cAMP production | F | 6.8 | pEC50 | 160 | nM | EC50 | J Med Chem (2010) 53: 471-480 [PMID:19902968] |
| ChEMBL | Agonist activity at human recombinant P2Y14 receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation proximity assay | F | 6.8 | pEC50 | 160 | nM | EC50 | J Med Chem (2010) 53: 4488-4501 [PMID:20446735] |
| GtoPdb | - | - | 7.13 | pEC50 | 74 | nM | EC50 | Mol Pharmacol (2009) 76: 1341-8 [PMID:19759354] |
| ChEMBL | Agonist activity at human P2Y14 expressed in HEK293 cells | B | 7.13 | pEC50 | 74 | nM | EC50 | J Med Chem (2016) 59: 9981-10005 [PMID:27413802] |
| ChEMBL | Agonist activity at human P2Y14 expressed in rat CHO cells | B | 7.48 | pEC50 | 33 | nM | EC50 | J Med Chem (2016) 59: 9981-10005 [PMID:27413802] |
| ChEMBL | Agonist activity at human P2Y14 expressed in rat C6 cells | B | 7.54 | pEC50 | 29 | nM | EC50 | J Med Chem (2016) 59: 9981-10005 [PMID:27413802] |
| P2Y14 receptor in Rat [GtoPdb: 330] [UniProtKB: O35881] | ||||||||
| GtoPdb | - | - | 6.5 | pIC50 | - | - | - | J Pharmacol Exp Ther (2008) 325: 588-94 [PMID:18252808] |
| P2Y2 receptor/Purinergic receptor P2Y2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231] | ||||||||
| ChEMBL | Evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 2 (P2Y2) | F | 4 | pEC50 | >100000 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
| ChEMBL | Agonist activity at human recombinant P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate intracellular accumulation by scintillation proximity assay | F | 4.78 | pEC50 | 16500 | nM | EC50 | J Med Chem (2011) 54: 2878-2890 [PMID:21417463] |
| ChEMBL | Agonist activity evaluated as change in the level of cytosolic calcium in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y2 receptor | F | 5 | pEC50 | >10000 | nM | EC50 | Bioorg Med Chem Lett (2001) 11: 157-160 [PMID:11206448] |
| P2Y4 receptor/Pyrimidinergic receptor P2Y4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2123] [GtoPdb: 325] [UniProtKB: P51582] | ||||||||
| ChEMBL | Agonist activity at human recombinant P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate intracellular accumulation by scintillation proximity assay | F | 4.85 | pEC50 | 14000 | nM | EC50 | J Med Chem (2011) 54: 2878-2890 [PMID:21417463] |
| P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4714] [GtoPdb: 326] [UniProtKB: Q15077] | ||||||||
| ChEMBL | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating Gq protein assessed as [3H]inositol phosphate production | F | 6.28 | pEC50 | 530 | nM | EC50 | J Med Chem (2010) 53: 471-480 [PMID:19902968] |
| GtoPdb | - | - | 6.5 | pEC50 | - | - | - | Biochem Biophys Res Commun (1996) 222: 303-8 [PMID:8670200] |
| ChEMBL | Antagonist activity at P2Y6 (unknown origin) | B | 6.52 | pEC50 | 300 | nM | EC50 | J Med Chem (2016) 59: 9981-10005 [PMID:27413802] |
| ChEMBL | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay | F | 6.52 | pEC50 | 300 | nM | EC50 | Bioorg Med Chem (2008) 16: 6319-6332 [PMID:18514530] |
| ChEMBL | Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation proximity assay | F | 6.52 | pEC50 | 300 | nM | EC50 | J Med Chem (2010) 53: 4488-4501 [PMID:20446735] |
| ChEMBL | The compound was evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 6 (P2Y6) | F | 6.52 | pEC50 | 300 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
| ChEMBL | Agonist activity at human GFP-tagged P2Y6 receptor expressed in human 1321N1 cells assessed as intracellular calcium mobilization by fura2/AM-based fluorescence spectrophotometry | F | 6.82 | pEC50 | 150 | nM | EC50 | Bioorg Med Chem (2012) 20: 5483-5495 [PMID:22901672] |
| ChEMBL | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as calcium elevation by fura2/AM assay | F | 6.85 | pEC50 | 140 | nM | EC50 | J Med Chem (2010) 53: 1673-1685 [PMID:20095577] |
| ChEMBL | Agonist activity evaluated as change in the level of cytosolic calcium in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y6 receptor | F | 7 | pEC50 | 100 | nM | EC50 | Bioorg Med Chem Lett (2001) 11: 157-160 [PMID:11206448] |
| ChEMBL | Stimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptor | B | 7.07 | pEC50 | 86 | nM | EC50 | J Med Chem (2005) 48: 8108-8111 [PMID:16366591] |
| ChEMBL | Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate intracellular accumulation by scintillation proximity assay | F | 7.32 | pEC50 | 48 | nM | EC50 | J Med Chem (2011) 54: 2878-2890 [PMID:21417463] |
| ChEMBL | Agonist activity at human P2Y6 receptor | F | 7.33 | pEC50 | 47 | nM | EC50 | Bioorg Med Chem (2012) 20: 5483-5495 [PMID:22901672] |
| ChEMBL | Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA | F | 7.38 | pEC50 | 42 | nM | EC50 | J Med Chem (2006) 49: 7076-7087 [PMID:17125260] |
| ChEMBL | Agonist activity at P2Y6 receptor expressed in human 1321N1 cells assessed as inositol phosphate accumulation | F | 7.82 | pEC50 | 15 | nM | EC50 | Bioorg Med Chem (2012) 20: 5483-5495 [PMID:22901672] |
| ChEMBL | Measure of Agonist Potency at human P2Y purinoceptor 6 (hP2Y6) stably expressed in 131N1 astrocytoma cell | F | 7.82 | pEC50 | 15 | nM | EC50 | J Med Chem (2002) 45: 208-218 [PMID:11754592] |
| ChEMBL | Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP production | F | 7.89 | pEC50 | 13 | nM | EC50 | J Med Chem (2006) 49: 5532-5543 [PMID:16942026] |
| P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3543] [GtoPdb: 326] [UniProtKB: Q63371] | ||||||||
| ChEMBL | Agonist activity at rat P2Y6 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysis | F | 6.7 | pEC50 | 200 | nM | EC50 | Eur J Med Chem (2009) 44: 1525-1536 [PMID:18760862] |
| ChEMBL | Agonist activity at rat P2Y purinoceptor 6 expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by spectrofluorimetry | F | 6.7 | pEC50 | 200 | nM | EC50 | J Med Chem (2012) 55: 437-448 [PMID:22107038] |
| UDP-galactopyranose mutase in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5169233] [UniProtKB: Q48485] | ||||||||
| ChEMBL | Inhibition of Klebsiella pneumoniae UGM expressed in Escherichia coli BL21(DE3) assessed as dissociation constant by fluorescence polarization assay | B | 4.27 | pKd | 54000 | nM | Kd | Bioorg Med Chem (2022) 69: 116896-116896 [PMID:35777270] |
| UDP-galactopyranose mutase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4450] [UniProtKB: P9WIQ1] | ||||||||
| ChEMBL | Inhibition of Mycobacterium tuberculosis UGM expressed in Escherichia coli BL21(DE3) assessed as dissociation constant by fluorescence polarization assay | B | 4.46 | pKd | 35000 | nM | Kd | Bioorg Med Chem (2022) 69: 116896-116896 [PMID:35777270] |
| UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5955] [UniProtKB: O15294] | ||||||||
| ChEMBL | Inhibition of human OGT | B | 5.74 | pIC50 | 1800 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 1199-1201 [PMID:21273069] |
| GPR17 in Human [GtoPdb: 88] [UniProtKB: Q13304] | ||||||||
| GtoPdb | [35S]GTPγS binding to 1321N1 cell membranes expressing hGPR17. | - | 8.8 | pEC50 | 1.6 | nM | EC50 |
Br J Pharmacol (2010) 159: 1092-105 [PMID:20148890]; EMBO J (2006) 25: 4615-27 [PMID:16990797] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
