ChEMBL ligand: CHEMBL357076 (J-113397)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!
NOP receptor/Nociceptin receptor in Human [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counter	B	6.4	pKi	>400	nM	Ki	J Med Chem (2012) 55: 4955-4967 [PMID:22541041]
ChEMBL	Binding affinity in CHO cells stably expressing cloned human Opioid receptor delta 1 by displacing radioligand [3H][D-Ala2,D-Leu5]enkephalin	B	5	pIC50	>10000	nM	IC50	J Med Chem (1999) 42: 5061-5063 [PMID:10602690]
ChEMBL	Displacement of [3H]naltrindole from cloned human delta opioid receptor expressed in CHO cells	B	5	pIC50	>10000	nM	IC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counter	B	6.4	pKi	>400	nM	Ki	J Med Chem (2012) 55: 4955-4967 [PMID:22541041]
ChEMBL	Displacement of [3H]U-69593 from cloned human kappa opioid receptor expressed in CHO cells	B	5.8	pIC50	1600	nM	IC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
ChEMBL	Binding affinity in CHO cells stably expressing cloned human Opioid receptor kappa 1 by displacing radioligand [3H]U-69593	B	5.85	pIC50	1400	nM	IC50	J Med Chem (1999) 42: 5061-5063 [PMID:10602690]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counter	B	6.4	pKi	>400	nM	Ki	J Med Chem (2012) 55: 4955-4967 [PMID:22541041]
ChEMBL	Displacement of [3H]diprenorphin from cloned human mu opioid receptor expressed in CHO cells	B	5.47	pIC50	3400	nM	IC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
ChEMBL	Binding affinity in CHO cells stably expressing cloned human Opioid receptor mu 1 by displacing diprenorphine	B	5.66	pIC50	2200	nM	IC50	J Med Chem (1999) 42: 5061-5063 [PMID:10602690]
NOP receptor/Nociceptin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146]
ChEMBL	Binding affinity towards Nociceptin/orphanin FQ (N/OFQ) receptor from recombinant HEK293 cell membranes was determined using binding assay	B	8.64	pKi	2.3	nM	Ki	Bioorg Med Chem Lett (2004) 14: 1347-1351 [PMID:14980696]
GtoPdb	-	-	8.7	pKi	-	-	-	Eur J Pharmacol (2000) 402: 45-53 [PMID:10940356]
ChEMBL	Displacement of [3H]Nociceptin from human recombinant NOP receptor expressed in CHO cells by scintillation counter	B	9.39	pKi	0.4	nM	Ki	J Med Chem (2012) 55: 4955-4967 [PMID:22541041]
ChEMBL	Antagonistic activity against nociceptin produced [35S]GTP-gamma-S, binding to Opioid receptor like 1 expressed in CHO cells	F	8.25	pIC50	5.6	nM	IC50	J Med Chem (1999) 42: 5061-5063 [PMID:10602690]
GtoPdb	-	-	8.3	pIC50	-	-	IC50	J Med Chem (1999) 42: 5061-3 [PMID:10602690]
ChEMBL	Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells	B	8.62	pIC50	2.4	nM	IC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
ChEMBL	Binding affinity in CHO cells stably expressing cloned human Opioid receptor like 1 by displacing radioligand [125I]Tyr14-nociceptin	B	8.64	pIC50	2.3	nM	IC50	J Med Chem (1999) 42: 5061-5063 [PMID:10602690]
ChEMBL	Displacement of [125I]Tyr14-nociceptin from human cloned ORL1 receptor expressed in CHO cells	B	8.64	pIC50	2.3	nM	IC50	J Med Chem (2009) 52: 4091-4094 [PMID:19537798]
ChEMBL	Antagonist activity on nociceptin-induced [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells	F	8.82	pIC50	1.5	nM	IC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
ChEMBL	Agonistic activity against nociceptin produced GTPgammaS binding to Opioid receptor like 1 expressed in CHO cells	B	5	pEC50	>10000	nM	EC50	J Med Chem (1999) 42: 5061-5063 [PMID:10602690]
ChEMBL	Agonist activity on nociceptin-induced maximal [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells	F	5	pEC50	>10000	nM	EC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]