ChEMBL ligand: CHEMBL485 (Codeine, Codeine monohydrate, Codeinum, Codeinum monohydricum, Dea no. 9050, IDS-NC-005(SECT.-2))
δ receptor/Delta-type opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa-type opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
MRGPRX2/Mas-related G-protein coupled receptor member X2 in Human [ChEMBL: CHEMBL5849] [GtoPdb: 157] [UniProtKB: Q96LB1] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu-type opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta-type opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Displacement of [3H]diprenorphine from recombinant delta opioid receptor expressed in C6 cells	B	4.28	pKi	52207	nM	Ki	J Med Chem (2008) 51: 2316-2320 [PMID:18311899]
ChEMBL	In vitro binding affinity against cloned human Opioid receptor delta 1 expressed in HEK 293S cells	B	5.03	pIC50	>9300	nM	IC50	J Med Chem (2003) 46: 34-48 [PMID:12502358]
κ receptor/Kappa-type opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]diprenorphine from recombinant kappa opioid receptor expressed in CHO cells	B	4.59	pKi	25411	nM	Ki	J Med Chem (2008) 51: 2316-2320 [PMID:18311899]
ChEMBL	In vitro binding affinity against cloned human Opioid receptor kappa 1 expressed in HEK 293S cells	B	4.82	pIC50	15000	nM	IC50	J Med Chem (2003) 46: 34-48 [PMID:12502358]
MRGPRX2/Mas-related G-protein coupled receptor member X2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5849] [GtoPdb: 157] [UniProtKB: Q96LB1]
ChEMBL	Agonist activity at N-terminal Flag-tagged human MRGPRX2 receptor expressed in tetracycline-induced FLP-IN/T-REX 293 cells assessed as increase in intracellular calcium release by FLIPR assay	F	5	pEC50	10000	nM	EC50	Nat Chem Biol (2017) 13: 529-536 [PMID:28288109]
ChEMBL	Agonist activity at MRGPRX2 (unknown origin) expressed in HTLA cells assessed as induction of beta-arrestin 2 recruitment incubated for 18 to 24 hrs by PRESTO-Tango assay	F	5.17	pEC50	6760.83	nM	EC50	Nat Chem Biol (2017) 13: 529-536 [PMID:28288109]
μ receptor/Mu-type opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Displacement of [3H]naloxone from human mu poioid receptor expressed in HEK293 cells	B	5.2	pKi	6300	nM	Ki	J Biol Chem (2007) 282: 27126-27132 [PMID:17616524]
ChEMBL	Displacement of [3H]diprenorphine from recombinant mu opioid receptor expressed in C6 cells	B	6.14	pKi	727	nM	Ki	J Med Chem (2008) 51: 2316-2320 [PMID:18311899]
GtoPdb	-	-	6.9	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
ChEMBL	In vitro binding affinity against cloned human Opioid receptor mu 1 expressed in HEK 293S cells	B	6.98	pIC50	105	nM	IC50	J Med Chem (2003) 46: 34-48 [PMID:12502358]
ChEMBL	Activation of human mu opioid receptor expressed in HEK293a cells co-expressing YFP-labelled alphai1 and CFP-labelled beta1gamma2 Gi subunits assessed as Gi protein activation by fluorescence resonance energy transfer	B	5.21	pEC50	6100	nM	EC50	J Biol Chem (2007) 282: 27126-27132 [PMID:17616524]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]