ChEMBL ligand: CHEMBL13470 (SNC-80)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] δ receptor/Delta opioid receptor in Mouse [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300] δ receptor/Delta opioid receptor in Rat [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] κ receptor/Kappa opioid receptor in Mouse [ChEMBL: CHEMBL4329] [GtoPdb: 318] [UniProtKB: P33534] κ receptor/Kappa opioid receptor in Rat [ChEMBL: CHEMBL3614] [GtoPdb: 318] [UniProtKB: P34975] Kappa opioid receptor in Guinea pig [ChEMBL: CHEMBL3952] [UniProtKB: P41144] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] μ receptor/Mu opioid receptor in Mouse [ChEMBL: CHEMBL2858] [GtoPdb: 319] [UniProtKB: P42866] μ receptor/Mu opioid receptor in Rat [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] Mu opioid receptor in Guinea pig [ChEMBL: CHEMBL4354] [UniProtKB: P97266] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Binding affinity against kappa opioid receptor using [35S]GTP-gamma-S, binding assay in guinea pig caudate membranes blocked with 6 nM nor-BNI	F	6.2	pKd	629	nM	Kd	Bioorg Med Chem Lett (1999) 9: 3347-3350 [PMID:10612597]
GtoPdb	-	-	7.2	pKi	-	-	-	Eur J Pharmacol (1997) 326: 101-4 [PMID:9178661]; J Med Chem (1994) 37: 2125-8 [PMID:8035418]
ChEMBL	Binding affinity for delta opioid receptor	B	8.77	pKi	1.7	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2109-2112 [PMID:15080989]
ChEMBL	Displacement of [3H]deltorphine 2 from human delta opioid receptor expressed in CHOK1 cells	B	8.77	pKi	1.7	nM	Ki	Bioorg Med Chem (2008) 16: 2870-2885 [PMID:18249546]
ChEMBL	Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptor	B	8.89	pKi	1.29	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5994-5998 [PMID:19800791]
ChEMBL	Displacement of [3H]diprenorphine from human delta opioid receptor in CHO cells	B	8.92	pKi	1.2	nM	Ki	J Med Chem (2008) 51: 5893-5896 [PMID:18788723]
ChEMBL	Displacement of [3H]-deltorphine from human delta opioid receptor expressed in CHO-K1 cells by scintillation counting analysis	B	8.92	pKi	1.2	nM	Ki	J Med Chem (2014) 57: 6845-6860 [PMID:25062506]
ChEMBL	Displacement of [3H]deltrophine from human delta opioid receptor expressed in CHO-K1 cells after 120 mins by liquid scintillation counting method	B	8.92	pKi	1.2	nM	Ki	Medchemcomm (2016) 7: 317-326
ChEMBL	Binding affinity was measured against mutated human Opioid receptor delta 1 (W248L)	B	7.31	pIC50	49.1	nM	IC50	J Med Chem (1998) 41: 4767-4776 [PMID:9822547]
ChEMBL	Binding affinity was measured against cloned human Opioid receptor delta 1 (wild-type,Wt)	B	8.55	pIC50	2.85	nM	IC50	J Med Chem (1998) 41: 4767-4776 [PMID:9822547]
ChEMBL	Binding inhibition of [3H]- -naltrindole (0.15 nM) to membranes in CHO cells expressing Opioid receptor delta 1	B	8.66	pIC50	2.2	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1323-1328 [PMID:10340622]
ChEMBL	Inhibition of binding of [3H]- -naltrindole (0.15 nM) to membranes from CHO cells expressing Opioid receptor delta 1	B	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1329-1334 [PMID:10340623]
ChEMBL	Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligand	B	8.88	pIC50	1.31	nM	IC50	J Med Chem (2000) 43: 3878-3894 [PMID:11052793]
ChEMBL	Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.	B	8.88	pIC50	1.31	nM	IC50	J Med Chem (2000) 43: 3895-3905 [PMID:11052794]
ChEMBL	Binding affinity for Opioid receptor delta 1 by the inhibition of binding of [3H]-p-DPDPE human cloned receptors.	B	8.89	pIC50	1.3	nM	IC50	J Med Chem (1997) 40: 2936-2947 [PMID:9288176]
ChEMBL	Agonistic activity towards opioid receptor delta 1 was determined in [35S]GTP-gamma-S, binding assay in guinea pig caudate	F	6.12	pEC50	760	nM	EC50	J Med Chem (2004) 47: 1400-1412 [PMID:14998329]
ChEMBL	Agonist activity at human delta opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS binding assay	F	6.68	pEC50	210	nM	EC50	ACS Med Chem Lett (2019) 10: 450-456 [PMID:30996778]
ChEMBL	Agonist activity at human recombinant delta opioid receptor expressed in human HEK293 cells by [35S]GTPgammaS binding assay	F	7.8	pEC50	15.7	nM	EC50	Bioorg Med Chem (2012) 20: 949-961 [PMID:22197670]
ChEMBL	Agonist activity at human recombinant delta opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay	F	7.8	pEC50	15.7	nM	EC50	Bioorg Med Chem Lett (2009) 19: 2792-2795 [PMID:19362480]
ChEMBL	Agonist activity at human DOR expressed in CHO cell membranes incubated for 1 hr by [35S]-GTPgammaS coupling assay	F	7.84	pEC50	14.4	nM	EC50	J Med Chem (2020) 63: 2673-2687 [PMID:31834798]
ChEMBL	Agonist activity at human delta opioid receptor in CHO cells assessed as stimulation of [35S]GTPgammaS binding	F	8	pEC50	10	nM	EC50	J Med Chem (2008) 51: 5893-5896 [PMID:18788723]
ChEMBL	Agonist activity at human DOR expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	F	8.12	pEC50	7.6	nM	EC50	ACS Med Chem Lett (2020) 11: 720-726 [PMID:32435376]
ChEMBL	Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	F	8.32	pEC50	4.8	nM	EC50	Bioorg Med Chem Lett (2009) 19: 2289-2294 [PMID:19282177]
ChEMBL	Agonist activity at human delta opioid receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assay	F	8.32	pEC50	4.8	nM	EC50	Bioorg Med Chem Lett (2007) 17: 6516-6520 [PMID:17935988]
ChEMBL	Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding	F	8.32	pEC50	4.8	nM	EC50	J Med Chem (2006) 49: 5635-5639 [PMID:16942039]
ChEMBL	Agonist activity at human delta opioid receptor expressed in CHO cells assessed as [35S]GTPgammaS binding after 60 mins by scintillation counting	F	8.32	pEC50	4.8	nM	EC50	Bioorg Med Chem Lett (2012) 22: 7340-7344 [PMID:23142613]
ChEMBL	Effective concentration as delta agonist potency using [35S]GTP-gamma-S binding assay.	F	8.44	pEC50	3.67	nM	EC50	J Med Chem (2000) 43: 3895-3905 [PMID:11052794]
ChEMBL	Agonist potency was measured using GTP gamma-[35S] binding assay	B	8.44	pEC50	3.67	nM	EC50	J Med Chem (2000) 43: 3878-3894 [PMID:11052793]
ChEMBL	Agonist activity at human delta opioid receptor by [35S]GTPgammaS binding assay	F	8.52	pEC50	2.99	nM	EC50	Bioorg Med Chem Lett (2009) 19: 5994-5998 [PMID:19800791]
ChEMBL	Agonist activity at human delta opioid receptor expressed in CHO cells assessed as [35S]-GTP[gammaS] binding	F	8.72	pEC50	1.9	nM	EC50	ACS Med Chem Lett (2014) 5: 368-372 [PMID:24900842]
ChEMBL	Agonist activity at human delta opioid receptor expressed in HEK293 cells by CellKey method	B	8.77	pEC50	1.7	nM	EC50	ACS Med Chem Lett (2014) 5: 368-372 [PMID:24900842]
δ receptor/Delta opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300]
ChEMBL	Displacement of [3H]-DPDPE from mouse DOR expressed in HEK293 cells	B	7.78	pKi	16.6	nM	Ki	ACS Med Chem Lett (2012) 3: 640-644 [PMID:23585918]
ChEMBL	Binding affinity against Opioid receptor delta 1 using [3H][D-Ala2, D-Leu5]-enkephalin as radioligand	B	8.77	pKi	1.7	nM	Ki	J Med Chem (1997) 40: 3192-3198 [PMID:9379438]
ChEMBL	Binding affinity towards opioid Delta receptor using [3H]DADLE as radioligand	B	8.8	pKi	1.57	nM	Ki	Bioorg Med Chem Lett (1999) 9: 3053-3056 [PMID:10571174]
ChEMBL	Binding affinity towards opioid Delta receptor using [3H]DADLE as radioligand	B	8.8	pKi	1.57	nM	Ki	Bioorg Med Chem Lett (1999) 9: 3347-3350 [PMID:10612597]
ChEMBL	Displacement of [3H]DPDPE from delta opioid receptor in mouse whole brain cerebellum membrane	B	8.98	pKi	1.04	nM	Ki	ACS Med Chem Lett (2014) 5: 368-372 [PMID:24900842]
ChEMBL	Displacement of [3H]DPDPE from mouse brain delta opioid receptor by scintillation counting analysis	B	9.15	pKi	0.71	nM	Ki	Eur J Med Chem (2013) 69: 413-426 [PMID:24090913]
ChEMBL	Tested for inhibition of binding of [3H]DADLE to mouse brain membranes depleted of mu binding sites by pretreatment with irreversible ligand BIT for delta opioid receptor	B	5.7	pIC50	>2000	nM	IC50	J Med Chem (1994) 37: 2125-2128 [PMID:8035418]
ChEMBL	Agonist activity was evaluated in mouse vas deferens (MVD) preparations at Opioid receptor delta 1	F	6.19	pIC50	646.8	nM	IC50	J Med Chem (1997) 40: 695-704 [PMID:9057856]
ChEMBL	In vitro antagonist activity against Opioid receptor delta 1 in the presence of 30 nM naltrindole, in a mouse vas deferens assay	F	6.2	pIC50	634	nM	IC50	J Med Chem (1997) 40: 3192-3198 [PMID:9379438]
ChEMBL	Tested for inhibition of binding of [3H]DADLE to mouse brain membranes depleted of mu binding sites by pretreatment with irreversible ligand BIT for delta opioid receptor	B	7.25	pIC50	56.5	nM	IC50	J Med Chem (1994) 37: 2125-2128 [PMID:8035418]
ChEMBL	In vitro agonist activity for Opioid receptor delta 1 was determined in a mouse vas deferens assay	F	8.1	pIC50	8	nM	IC50	J Med Chem (1997) 40: 3192-3198 [PMID:9379438]
ChEMBL	Displacement of [3H]DPDPE from delta opioid receptor in mouse whole brain without cerebellum	B	8.19	pIC50	6.41	nM	IC50	Bioorg Med Chem Lett (2008) 18: 6398-6401 [PMID:18990576]
ChEMBL	Displacement of [3H]DPDPE from delta opioid receptor in ICR mouse whole brain	B	8.19	pIC50	6.41	nM	IC50	Bioorg Med Chem (2008) 16: 4304-4312 [PMID:18337104]
ChEMBL	Agonist activity was evaluated in mouse vas deferens (MVD) preparations at Opioid receptor delta 1	F	8.27	pIC50	5.34	nM	IC50	J Med Chem (1997) 40: 695-704 [PMID:9057856]
ChEMBL	Agonist activity using electrically induced smooth muscle contraction of mouse vas deferens.	F	8.56	pIC50	2.73	nM	IC50	J Med Chem (1999) 42: 5455-5463 [PMID:10639287]
ChEMBL	Agonist activity was evaluated in mouse vas deferens (MVD) preparations at Opioid receptor delta 1	F	8.56	pIC50	2.73	nM	IC50	J Med Chem (1997) 40: 695-704 [PMID:9057856]
ChEMBL	Agonistic activity towards Opioid receptor delta 1 as inhibitory activity towards electrically stimulated mouse vas deferens	F	8.57	pIC50	2.7	nM	IC50	J Med Chem (1996) 39: 2081-2086 [PMID:8642567]
ChEMBL	Agonist activity at delta opioid receptor in mouse vas deferens	F	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2006) 16: 905-910 [PMID:16290934]
ChEMBL	Displacement of [3H]DPDPE from mouse delta opioid receptor expressed in HEK293 cells by liquid scintillation counting	B	9.1	pIC50	0.8	nM	IC50	Bioorg Med Chem (2009) 17: 6442-6450 [PMID:19646882]
δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533]
ChEMBL	Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membrane	B	8.25	pKi	5.6	nM	Ki	J Med Chem (2004) 47: 1400-1412 [PMID:14998329]
ChEMBL	In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement.	B	8.4	pKi	4	nM	Ki	J Med Chem (1999) 42: 5455-5463 [PMID:10639287]
ChEMBL	Displacement of [3H]DADLE from delta opioid receptor in rat brain after 60 mins by liquid scintillation counting method	B	8.45	pKi	3.53	nM	Ki	Bioorg Med Chem (2017) 25: 2406-2422 [PMID:28314512]
ChEMBL	Inhibition of [3H]DPDPE radioligand binding to rat opioid receptor delta 1 site from rat brain membranes	B	8.77	pKi	1.7	nM	Ki	Bioorg Med Chem Lett (2000) 10: 1109-1111 [PMID:10843229]
ChEMBL	Inhibition of binding of [3H]-DPDPE to opioid receptor delta 1 from rat brain membrane.	B	8.77	pKi	1.7	nM	Ki	Bioorg Med Chem Lett (2001) 11: 1741-1743 [PMID:11425550]
ChEMBL	Affinity of [H]DADLE to the delta opioid receptor from rat brain	B	8.8	pKi	1.57	nM	Ki	J Med Chem (2001) 44: 972-987 [PMID:11300879]
ChEMBL	Compound was evaluated for binding affinity towards Opioid receptor delta 1 by displacement of [3H]-DADLE radioligand	B	8.8	pKi	1.57	nM	Ki	Bioorg Med Chem Lett (2000) 10: 1281-1284 [PMID:10866400]
ChEMBL	Inhibitory activity against Opioid receptor delta 1 in rat brain membranes using [3H]DADLE as a radioligand.	B	8.82	pKi	1.5	nM	Ki	J Med Chem (2000) 43: 3193-3196 [PMID:10956228]
ChEMBL	Displacement of [3H]DPDPE from DOR in Sprague-Dawley rat brain membranes after 120 mins by scintillation counting method	B	8.92	pKi	1.2	nM	Ki	J Med Chem (2019) 62: 893-907 [PMID:30543421]
ChEMBL	Displacement of [3H]-DPDPE from DOR in rat brain membranes measured by competitive radioligand receptor binding assay	B	8.92	pKi	1.2	nM	Ki	Eur J Med Chem (2022) 230: 114079-114079 [PMID:35033825]
ChEMBL	Inhibition of radioligand [3H]DADLE binding to rat brain Opioid receptor delta 1	B	6.37	pIC50	430	nM	IC50	J Med Chem (1997) 40: 695-704 [PMID:9057856]
ChEMBL	Inhibition of [3H]- DADLE binding to Rat brain Opioid receptor delta 1	B	8.54	pIC50	2.9	nM	IC50	J Med Chem (1996) 39: 2081-2086 [PMID:8642567]
ChEMBL	Binding affinity for Opioid receptor delta 1 by the inhibition of binding of [3H]DADAL in rat brain membranes.	B	8.54	pIC50	2.9	nM	IC50	J Med Chem (1997) 40: 2936-2947 [PMID:9288176]
ChEMBL	Inhibition of radioligand [3H]DADLE binding to rat brain Opioid receptor delta 1	B	8.54	pIC50	2.88	nM	IC50	J Med Chem (1997) 40: 695-704 [PMID:9057856]
ChEMBL	Binding affinity was measured against Opioid receptor delta 1 using [3H]p-Cl-DPDPE as radioligand.	B	8.97	pIC50	1.06	nM	IC50	J Med Chem (1998) 41: 4767-4776 [PMID:9822547]
ChEMBL	Agonist activity at rat delta opioid receptor expressed in rat C6 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by radioimmunoassay	F	6.78	pEC50	166	nM	EC50	J Med Chem (2009) 52: 7724-7731 [PMID:19788201]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [125I]D-pro10-dynorphin from human cloned kappa opioid receptor	B	5.38	pKi	4169	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5994-5998 [PMID:19800791]
ChEMBL	Binding affinity towards opioid kappa receptor using [3H]U-69593 as radioligand	B	5.45	pKi	3535	nM	Ki	Bioorg Med Chem Lett (1999) 9: 3053-3056 [PMID:10571174]
ChEMBL	Binding affinity towards opioid kappa receptor using [3H]U-69593 as radioligand	B	5.45	pKi	3535	nM	Ki	Bioorg Med Chem Lett (1999) 9: 3347-3350 [PMID:10612597]
ChEMBL	Binding affinity on cloned opioid receptor kappa 1 in human HEK293S cells using [125I]-D-Pro10-dynorphin A[1-11] as radioligand.	B	5.61	pIC50	2480	nM	IC50	J Med Chem (2000) 43: 3895-3905 [PMID:11052794]
ChEMBL	Binding affinity against cloned human Opioid receptor kappa 1 using [125I]-D-Pro10-dynorphin A[1-11] as radioligand	B	5.61	pIC50	2480	nM	IC50	J Med Chem (2000) 43: 3878-3894 [PMID:11052793]
ChEMBL	Agonist activity at human kappa opioid receptor expressed in HEK293 cells by CellKey method	B	5.28	pEC50	5264	nM	EC50	ACS Med Chem Lett (2014) 5: 368-372 [PMID:24900842]
κ receptor/Kappa opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4329] [GtoPdb: 318] [UniProtKB: P33534]
ChEMBL	Displacement of [3H]U-69,593 from mouse brain kappa opioid receptor by scintillation counting analysis	B	5.56	pKi	2750	nM	Ki	Eur J Med Chem (2013) 69: 413-426 [PMID:24090913]
ChEMBL	Binding affinity against Opioid receptor kappa 1 using [3H]-U-69,593 as radioligand	B	5.87	pKi	1348	nM	Ki	J Med Chem (1997) 40: 3192-3198 [PMID:9379438]
κ receptor/Kappa opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3614] [GtoPdb: 318] [UniProtKB: P34975]
ChEMBL	Affinity of [3H]U-69593 to opioid receptor kappa 1 from rat brain	B	5.45	pKi	3535	nM	Ki	J Med Chem (2001) 44: 972-987 [PMID:11300879]
ChEMBL	Displacement of [3H]U69593 from rat kappa opioid receptor expressed in HEK293 cells by liquid scintillation counting	B	5.44	pIC50	3601	nM	IC50	Bioorg Med Chem (2009) 17: 6442-6450 [PMID:19646882]
Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144]
ChEMBL	Binding affinity against kappa opioid receptor using [35S]GTP-gamma-S, binding assay in guinea pig caudate membranes blocked with 6 nM nor-BNI	F	6.2	pKd	629	nM	Kd	Bioorg Med Chem Lett (1999) 9: 3053-3056 [PMID:10571174]
ChEMBL	In vitro radioligand binding assay, for inhibition of [3H]U-69593 binding to Opioid receptor kappa 1, in guinea pig brain membranes.	B	4.93	pKi	11700	nM	Ki	J Med Chem (1999) 42: 5455-5463 [PMID:10639287]
ChEMBL	Binding affinity at Opioid receptor kappa 1 by displacement of [3H]U-69593 in guinea pig brain membranes	B	5.06	pKi	8760	nM	Ki	J Med Chem (2004) 47: 1400-1412 [PMID:14998329]
ChEMBL	Compound was evaluated for binding affinity towards Opioid receptor kappa 1 by displacement of [3H]U-69593 radioligand	B	5.45	pKi	3535	nM	Ki	Bioorg Med Chem Lett (2000) 10: 1281-1284 [PMID:10866400]
ChEMBL	Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cerebellum membrane	B	6	pKi	>1000	nM	Ki	ACS Med Chem Lett (2014) 5: 368-372 [PMID:24900842]
ChEMBL	Binding affinity for Opioid receptor kappa 1 by the inhibition of binding of [3H]U-69593 in guinea pig brain membranes.	B	5.15	pIC50	7070	nM	IC50	J Med Chem (1997) 40: 2936-2947 [PMID:9288176]
ChEMBL	Binding affinity towards Opioid receptor kappa 1 using [3H]- U-69,593 (1.5 nM) as radioligand in guinea pig brain membranes	B	5.39	pIC50	4100	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1323-1328 [PMID:10340622]
ChEMBL	Binding affinity towards Opioid receptor kappa 1 using [3H]- U-69,593 (1.5 nM) as radioligand in guinea pig brain membranes	B	5.39	pIC50	4100	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1329-1334 [PMID:10340623]
ChEMBL	Agonist activity at kappa opioid receptor in myenteric plexus muscle from guinea pig	F	5.9	pIC50	1258.93	nM	IC50	Bioorg Med Chem Lett (2006) 16: 905-910 [PMID:16290934]
ChEMBL	Inhibition of [3H]- U69,593 binding to Guinea pig Opioid receptor kappa 1	B	6	pIC50	>1000	nM	IC50	J Med Chem (1996) 39: 2081-2086 [PMID:8642567]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Binding affinity for mu opioid receptor	B	5.89	pKi	1300	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2109-2112 [PMID:15080989]
ChEMBL	Displacement of [125I]FK33824 from human cloned mu opioid receptor	B	6.45	pKi	352	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5994-5998 [PMID:19800791]
ChEMBL	Binding affinity for micro receptors by the inhibition of binding of [3H]DAMGO to Opioid receptor mu 1 in human cloned receptors.	B	5.32	pIC50	4785	nM	IC50	J Med Chem (1997) 40: 2936-2947 [PMID:9288176]
ChEMBL	Binding affinity on cloned opioid receptor mu 1 in human HEK293S cells using [125I]FK33824 as radioligand.	B	6.49	pIC50	320	nM	IC50	J Med Chem (2000) 43: 3895-3905 [PMID:11052794]
ChEMBL	Binding affinity against cloned human Opioid receptor mu 1 using [125I]FK33824 as radioligand	B	6.49	pIC50	320	nM	IC50	J Med Chem (2000) 43: 3878-3894 [PMID:11052793]
ChEMBL	Agonist activity at human mu opioid receptor expressed in HEK293 cells by CellKey method	B	9.85	pEC50	0.14	nM	EC50	ACS Med Chem Lett (2014) 5: 368-372 [PMID:24900842]
μ receptor/Mu opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2858] [GtoPdb: 319] [UniProtKB: P42866]
ChEMBL	Displacement of [3H]DAMGO from mouse brain mu opioid receptor by scintillation counting analysis	B	5.62	pKi	2383	nM	Ki	Eur J Med Chem (2013) 69: 413-426 [PMID:24090913]
ChEMBL	Binding affinity against Opioid receptor mu 1 using [3H][D-Ala2, MePhe4, Gly-ol5]-enkephalin as radioligand	B	5.89	pKi	1300	nM	Ki	J Med Chem (1997) 40: 3192-3198 [PMID:9379438]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor in mouse whole brain cerebellum membrane	B	6.16	pKi	695	nM	Ki	ACS Med Chem Lett (2014) 5: 368-372 [PMID:24900842]
ChEMBL	Displacement of [3H]DAMGO from mouse mu opioid receptor expressed in HEK293 cells by liquid scintillation counting	B	5.22	pIC50	6066	nM	IC50	Bioorg Med Chem (2009) 17: 6442-6450 [PMID:19646882]
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
ChEMBL	Binding affinity at Opioid receptor mu 1 by displacement of [3H]DAMGO in rat brain membrane	B	5.09	pKi	8070	nM	Ki	J Med Chem (2004) 47: 1400-1412 [PMID:14998329]
ChEMBL	In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membranes.	B	5.4	pKi	3970	nM	Ki	J Med Chem (1999) 42: 5455-5463 [PMID:10639287]
ChEMBL	Affinity of [3H]DAMGO to the mu opioid receptor from rat brain	B	5.79	pKi	1614	nM	Ki	J Med Chem (2001) 44: 972-987 [PMID:11300879]
ChEMBL	Compound was evaluated for binding affinity towards Opioid receptor mu 1 by displacement of [3H]-DAMGO radioligand	B	5.79	pKi	1614	nM	Ki	Bioorg Med Chem Lett (2000) 10: 1281-1284 [PMID:10866400]
ChEMBL	Binding affinity towards opioid Mu receptor using [3H]DAMGO as radioligand	B	5.79	pKi	1614	nM	Ki	Bioorg Med Chem Lett (1999) 9: 3347-3350 [PMID:10612597]
ChEMBL	Binding affinity towards opioid Mu receptor using [3H]DAMGO as radioligand	B	5.79	pKi	1614	nM	Ki	Bioorg Med Chem Lett (1999) 9: 3053-3056 [PMID:10571174]
ChEMBL	Binding affinity by inhibition of [3H]DAMGO binding to Opioid receptor mu 1 from rat brain membranes	B	5.89	pKi	1300	nM	Ki	Bioorg Med Chem Lett (2000) 10: 1109-1111 [PMID:10843229]
ChEMBL	Inhibition of binding of [3H]DAMGO to opioid receptor mu 1 from rat brain membrane.	B	5.89	pKi	1300	nM	Ki	Bioorg Med Chem Lett (2001) 11: 1741-1743 [PMID:11425550]
ChEMBL	Inhibition of radioligand [3H]DAMGO binding to rat brain Opioid receptor mu 1 using 100 nM DAMGO	B	5.03	pIC50	9366	nM	IC50	J Med Chem (1997) 40: 695-704 [PMID:9057856]
ChEMBL	Evaluated for inhibition of [3H]DAMGO binding from mu receptor in rat brain membranes	B	5.03	pIC50	9366	nM	IC50	J Med Chem (1994) 37: 2125-2128 [PMID:8035418]
ChEMBL	Evaluated for inhibition of [3H]DAMGO binding from mu receptor in rat brain membranes	B	5.24	pIC50	5712	nM	IC50	J Med Chem (1994) 37: 2125-2128 [PMID:8035418]
ChEMBL	Binding affinity towards mu opioid receptor using [3H]- -DAMGO (1.5 nM) as radioligand in rat brain membranes	B	5.32	pIC50	4800	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1329-1334 [PMID:10340623]
ChEMBL	Binding affinity towards mu opioid receptor using [3H]- -DAMGO (1.5 nM) as radioligand in rat brain membranes	B	5.32	pIC50	4800	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1323-1328 [PMID:10340622]
ChEMBL	Binding affinity was measured against Opioid receptor mu 1 using [3H]-DAMGO as radioligand.	B	5.6	pIC50	2500	nM	IC50	J Med Chem (1998) 41: 4767-4776 [PMID:9822547]
ChEMBL	Binding affinity for Opioid receptor mu 1 by the inhibition of binding of [3H]DAMGO in rat brain membranes.	B	5.61	pIC50	2467	nM	IC50	J Med Chem (1997) 40: 2936-2947 [PMID:9288176]
ChEMBL	Inhibition of radioligand [3H]DAMGO binding to rat brain Opioid receptor mu 1 using 100 nM DAMGO	B	5.61	pIC50	2467	nM	IC50	J Med Chem (1997) 40: 695-704 [PMID:9057856]
ChEMBL	Inhibition of [3H]- DAMGO binding to Rat brain Opioid receptor mu 1	B	5.61	pIC50	2467	nM	IC50	J Med Chem (1996) 39: 2081-2086 [PMID:8642567]
Mu opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266]
ChEMBL	Binding affinity against Mu opioid receptor using [35S]GTP-gamma-S, binding assay in guinea pig caudate membranes blocked with 6000 nM CTAP	F	6.17	pKd	673	nM	Kd	Bioorg Med Chem Lett (1999) 9: 3053-3056 [PMID:10571174]
ChEMBL	Binding affinity against Mu opioid receptor using [35S]GTP-gamma-S, binding assay in guinea pig caudate membranes blocked with 6000 nM CTAP	F	6.17	pKd	673	nM	Kd	Bioorg Med Chem Lett (1999) 9: 3347-3350 [PMID:10612597]
ChEMBL	Binding affinity against Mu opioid receptor using [35S]GTP-gamma-S, binding assay in guinea pig caudate membranes in unblocked condition	F	6.5	pKd	317	nM	Kd	Bioorg Med Chem Lett (1999) 9: 3053-3056 [PMID:10571174]
ChEMBL	Binding affinity against Mu opioid receptor using [35S]GTP-gamma-S, binding assay in guinea pig caudate membranes in unblocked condition	F	6.5	pKd	317	nM	Kd	Bioorg Med Chem Lett (1999) 9: 3347-3350 [PMID:10612597]
ChEMBL	Agonist activity at mu opioid receptor in myenteric plexus muscle from guinea pig	F	5	pIC50	<10000	nM	IC50	Bioorg Med Chem Lett (2006) 16: 905-910 [PMID:16290934]
ChEMBL	Agonistic activity for Opioid receptor mu 1 as inhibitory activity towards electrically stimulated guinea pig ileum	F	5.26	pIC50	5457	nM	IC50	J Med Chem (1996) 39: 2081-2086 [PMID:8642567]
ChEMBL	Agonist activity was evaluated in guinea pig ileum (GPI) preparations at Opioid receptor mu 1	F	5.26	pIC50	5457	nM	IC50	J Med Chem (1997) 40: 695-704 [PMID:9057856]
ChEMBL	Agonist activity using strips of guinea pig ileum longitudinal muscle myenteric plexus.	F	5.26	pIC50	5450	nM	IC50	J Med Chem (1999) 42: 5455-5463 [PMID:10639287]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay	F	5.1	pIC50	7943.28	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay	F	5.2	pIC50	6309.57	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay	F	5.4	pIC50	3981.07	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay	F	5.5	pIC50	3162.28	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay	F	5.5	pIC50	3162.28	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay	F	5.6	pIC50	2511.89	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay	F	5.6	pIC50	2511.89	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]