L-152,804 [Ligand Id: 1565] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL491762 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Y1 receptor/Neuropeptide Y receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4777] [GtoPdb: 305] [UniProtKB: P25929] | ||||||||
| ChEMBL | Inhibition of human neuropeptide Y1 receptor | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2008) 51: 4765-4770 [PMID:18637668] |
| Y2 receptor/Neuropeptide Y receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4018] [GtoPdb: 306] [UniProtKB: P49146] | ||||||||
| ChEMBL | Inhibition of human neuropeptide Y2 receptor | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2008) 51: 4765-4770 [PMID:18637668] |
| Y4 receptor/Neuropeptide Y receptor type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4877] [GtoPdb: 307] [UniProtKB: P50391] | ||||||||
| ChEMBL | Inhibition of human neuropeptide Y4 receptor | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2008) 51: 4765-4770 [PMID:18637668] |
| Y5 receptor/Neuropeptide Y receptor type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4561] [GtoPdb: 308] [UniProtKB: Q15761] | ||||||||
| ChEMBL | Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells | B | 7.48 | pKi | 33 | nM | Ki | J Med Chem (2009) 52: 3385-3396 [PMID:19459652] |
| ChEMBL | Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase deficient human LM cells | B | 7.48 | pKi | 33 | nM | Ki | J Med Chem (2008) 51: 4765-4770 [PMID:18637668] |
| GtoPdb | - | - | 7.6 | pKi | - | - | - | Biochem Biophys Res Commun (2000) 272: 169-73 [PMID:10872822] |
| ChEMBL | Antagonist activity at human recombinant neuropeptide Y5 receptor expressed in CHO cells coexpressing Gqi5 assessed as inhibition of neuropeptide Y-induced increase in intracellular calcium concentration | F | 7.21 | pIC50 | 61 | nM | IC50 | J Med Chem (2008) 51: 4765-4770 [PMID:18637668] |
| Y5 receptor in Rat [GtoPdb: 308] [UniProtKB: Q63634] | ||||||||
| GtoPdb | - | - | 7.5 | pKi | - | - | - | Biochem Biophys Res Commun (2000) 272: 169-73 [PMID:10872822] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
