BIBO3304 [Ligand Id: 1528] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1774204 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Y1 receptor/Neuropeptide Y receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4777] [GtoPdb: 305] [UniProtKB: P25929] | ||||||||
| ChEMBL | Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells | B | 9.6 | pKi | 0.25 | nM | Ki | Bioorg Med Chem (2011) 19: 2859-2878 [PMID:21493077] |
| ChEMBL | Radioligand binding assay (NPY1R, BHK) | B | 9.16 | pIC50 | 0.69 | nM | IC50 | Data for DCP probe BIBO3304 |
| ChEMBL | Radioligand binding assay (NPY1R, SK-N-MC) | B | 9.42 | pIC50 | 0.38 | nM | IC50 | Data for DCP probe BIBO3304 |
| GtoPdb | - | - | 9.5 | pIC50 | 0.38 | nM | IC50 | Br J Pharmacol (1998) 125: 549-555 [PMID:9806339] |
| Y1 receptor/Neuropeptide Y receptor type 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2587] [GtoPdb: 305] [UniProtKB: P21555] | ||||||||
| ChEMBL | Radioligand binding assay (NPY1R, HEK293, rat) | B | 9.14 | pIC50 | 0.72 | nM | IC50 | Data for DCP probe BIBO3304 |
| GtoPdb | - | - | 9.7 | pIC50 | - | - | - | Br J Pharmacol (2000) 129: 37-46 [PMID:10694200] |
| Y2 receptor/Neuropeptide Y receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4018] [GtoPdb: 306] [UniProtKB: P49146] | ||||||||
| ChEMBL | Radioligand binding assay (NPY2R, SMS-KAN cells) | B | 5 | pIC50 | >10000 | nM | IC50 | Data for DCP probe BIBO3304 |
| ChEMBL | Radioligand binding assay (NPY2R, BHK) | B | 6 | pIC50 | >1000 | nM | IC50 | Data for DCP probe BIBO3304 |
| Y2 receptor/Neuropeptide Y receptor type 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3309] [GtoPdb: 306] [UniProtKB: Q9ERC0] | ||||||||
| ChEMBL | Radioligand binding assay (NPY2R, rat hippocampus) | B | 5 | pIC50 | >10000 | nM | IC50 | Data for DCP probe BIBO3304 |
| Y4 receptor/Neuropeptide Y receptor type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4877] [GtoPdb: 307] [UniProtKB: P50391] | ||||||||
| ChEMBL | Binding affinity to human neuropeptide Y receptor type 4 receptor expressed in CHO cells using Cy5-[K4]-hPP by flow cytometric analysis | B | 5.3 | pKi | >5000 | nM | Ki | Bioorg Med Chem (2013) 21: 6303-6322 [PMID:24074877] |
| ChEMBL | Radioligand binding assay (human NPY4R, CHO cells) | B | 4.91 | pIC50 | 12300 | nM | IC50 | Data for DCP probe BIBO3304 |
| Y4 receptor/Neuropeptide Y receptor type 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4827] [GtoPdb: 307] [UniProtKB: Q63447] | ||||||||
| ChEMBL | Radioligand binding assay (rat NPY4R, CHO cells) | B | 5 | pIC50 | >10000 | nM | IC50 | Data for DCP probe BIBO3304 |
| Y5 receptor/Neuropeptide Y receptor type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4561] [GtoPdb: 308] [UniProtKB: Q15761] | ||||||||
| ChEMBL | Radioligand binding assay (human NPY5R, HEK293) | B | 5 | pIC50 | >10000 | nM | IC50 | Data for DCP probe BIBO3304 |
| Y5 receptor/Neuropeptide Y receptor type 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2548] [GtoPdb: 308] [UniProtKB: Q63634] | ||||||||
| ChEMBL | Radioligand binding assay (rat NPY5R, CHO cells) | B | 4.68 | pIC50 | 21000 | nM | IC50 | Data for DCP probe BIBO3304 |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
