ChEMBL ligand: CHEMBL438945 (Human neuropeptide y)
Y1 receptor/Neuropeptide Y receptor type 1 in Human [ChEMBL: CHEMBL4777] [GtoPdb: 305] [UniProtKB: P25929] Y1 receptor in Rat [GtoPdb: 305] [UniProtKB: P21555] There should be some charts here, you may need to enable JavaScript!
Y2 receptor/Neuropeptide Y receptor type 2 in Human [ChEMBL: CHEMBL4018] [GtoPdb: 306] [UniProtKB: P49146] Y2 receptor in Rat [GtoPdb: 306] [UniProtKB: Q9ERC0] There should be some charts here, you may need to enable JavaScript!
Y4 receptor/Neuropeptide Y receptor type 4 in Human [ChEMBL: CHEMBL4877] [GtoPdb: 307] [UniProtKB: P50391] Y4 receptor in Rat [GtoPdb: 307] [UniProtKB: Q63447] There should be some charts here, you may need to enable JavaScript!
Y5 receptor/Neuropeptide Y receptor type 5 in Human [ChEMBL: CHEMBL4561] [GtoPdb: 308] [UniProtKB: Q15761] Y5 receptor in Rat [GtoPdb: 308] [UniProtKB: Q63634] There should be some charts here, you may need to enable JavaScript!
PrRP receptor in Human [GtoPdb: 337] [UniProtKB: P49683] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Y1 receptor/Neuropeptide Y receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4777] [GtoPdb: 305] [UniProtKB: P25929]
ChEMBL	Displacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometry	B	9.3	pKi	0.5	nM	Ki	J Med Chem (2013) 56: 8422-8431 [PMID:24090364]
ChEMBL	Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins	B	9.68	pKi	0.21	nM	Ki	Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082]
ChEMBL	Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay	B	10.02	pKi	0.1	nM	Ki	Eur J Med Chem (2013) 63: 85-94 [PMID:23466604]
ChEMBL	Displacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBN	B	8.59	pIC50	2.6	nM	IC50	Bioorg Med Chem Lett (2013) 23: 687-692 [PMID:23265893]
ChEMBL	Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting	B	8.92	pIC50	1.2	nM	IC50	J Nat Prod (2009) 72: 2172-2176 [PMID:19916528]
ChEMBL	Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins	B	9.66	pIC50	0.22	nM	IC50	Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082]
ChEMBL	Displacement of [125I]peptide YY from Y1 receptor in human SK-N-MC cells measured after 120 mins by scintillation counting method	B	9.68	pIC50	0.21	nM	IC50	Bioorg Med Chem (2017) 25: 471-482 [PMID:27876250]
ChEMBL	Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay	B	9.85	pIC50	0.14	nM	IC50	Eur J Med Chem (2013) 63: 85-94 [PMID:23466604]
ChEMBL	Binding affinity to human neuropeptide Y1 receptor by radioligand displacement assay	B	10.15	pIC50	0.07	nM	IC50	Bioorg Med Chem (2013) 21: 2764-2771 [PMID:23582449]
Y1 receptor in Rat [GtoPdb: 305] [UniProtKB: P21555]
GtoPdb	-	-	10.5	pKi	-	-	-	Peptides (1997) 18: 397-401 [PMID:9145427]
GtoPdb	-	-	8.8	pIC50	-	-	-	Mol Pharmacol (1992) 41: 817-21 [PMID:1316999]
Y2 receptor/Neuropeptide Y receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4018] [GtoPdb: 306] [UniProtKB: P49146]
ChEMBL	Displacement of Cy5-pNPY from human Y2 receptor expressed in CHO cells after 90 to 120 mins by flow cytometry	B	9.1	pKi	0.8	nM	Ki	J Med Chem (2013) 56: 8422-8431 [PMID:24090364]
GtoPdb	-	-	9.5	pKi	-	-	-	Mol Pharmacol (1996) 49: 224-8 [PMID:8632753]; J Biol Chem (1995) 270: 26758-61 [PMID:7592910]
ChEMBL	Binding affinity to human neuropeptide Y receptor type 2 by radioligand displacement assay	B	10.12	pKi	0.08	nM	Ki	Eur J Med Chem (2013) 63: 85-94 [PMID:23466604]
ChEMBL	Compound was evaluated for its inhibitory activity against Y2 receptor of rabbit kidney membrane	B	9.3	pIC50	0.5	nM	IC50	Bioorg Med Chem Lett (1993) 3: 937-942
ChEMBL	Binding affinity to human neuropeptide Y receptor type 2 by radioligand displacement assay	B	9.72	pIC50	0.19	nM	IC50	Eur J Med Chem (2013) 63: 85-94 [PMID:23466604]
ChEMBL	Binding affinity to human neuropeptide Y2 receptor by radioligand displacement assay	B	10.05	pIC50	0.09	nM	IC50	Bioorg Med Chem (2013) 21: 2764-2771 [PMID:23582449]
ChEMBL	Displacement of [125I]peptide YY from Y2 receptor in human KAN-TS cells measured after 60 mins by scintillation counting method	B	10.55	pIC50	0.03	nM	IC50	Bioorg Med Chem (2017) 25: 471-482 [PMID:27876250]
Y2 receptor in Rat [GtoPdb: 306] [UniProtKB: Q9ERC0]
GtoPdb	-	-	9.4	pKi	-	-	-	Mol Pharmacol (2001) 60: 124-34 [PMID:11408607]
Y4 receptor/Neuropeptide Y receptor type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4877] [GtoPdb: 307] [UniProtKB: P50391]
ChEMBL	Displacement of Cy5-[K4]hPP from human Y4 receptor expressed in CHO cells after 90 to 120 mins by flow cytometry	B	6.55	pKi	282	nM	Ki	J Med Chem (2013) 56: 8422-8431 [PMID:24090364]
GtoPdb	-	-	8	pKi	-	-	-	J Biol Chem (1995) 270: 29123-8 [PMID:7493937]
ChEMBL	Agonist activity at human Y4 receptor expressed in sf9 cells assessed as hydrolysis of [gamma-33P]GTP after 2 mins by scintillation counting analysis	B	6.38	pEC50	417	nM	EC50	J Med Chem (2013) 56: 8422-8431 [PMID:24090364]
Y4 receptor in Rat [GtoPdb: 307] [UniProtKB: Q63447]
GtoPdb	-	-	6.4	pKi	-	-	-	Peptides (1997) 18: 609-12 [PMID:9210181]
GtoPdb	-	-	8.8	pKi	-	-	-	Peptides (1997) 18: 397-401 [PMID:9145427]; Peptides (1997) 18: 609-12 [PMID:9210181]
Y5 receptor/Neuropeptide Y receptor type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4561] [GtoPdb: 308] [UniProtKB: Q15761]
ChEMBL	Displacement of Cy5-pNPY from human Y5 receptor expressed in human HEC-1B cells after 90 to 120 mins by flow cytometry	B	8.66	pKi	2.2	nM	Ki	J Med Chem (2013) 56: 8422-8431 [PMID:24090364]
GtoPdb	-	-	9.1	pKi	-	-	-	J Biol Chem (1996) 271: 26315-9 [PMID:8824284]
ChEMBL	Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK293 cell membranes.	B	8.52	pIC50	3	nM	IC50	J Med Chem (2000) 43: 346-350 [PMID:10669561]
Y5 receptor in Rat [GtoPdb: 308] [UniProtKB: Q63634]
GtoPdb	-	-	9.3	pKi	-	-	-	J Biol Chem (1996) 271: 26315-9 [PMID:8824284]
PrRP receptor in Human [GtoPdb: 337] [UniProtKB: P49683]
GtoPdb	-	-	5.4	pKi	-	-	-	Genomics (2005) 85: 688-703 [PMID:15885496]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]