ChEMBL ligand: CHEMBL438945 (Human neuropeptide y)
Y1 receptor/Neuropeptide Y receptor type 1 in Human [ChEMBL: CHEMBL4777] [GtoPdb: 305] [UniProtKB: P25929] Y1 receptor in Rat [GtoPdb: 305] [UniProtKB: P21555] There should be some charts here, you may need to enable JavaScript!
Y2 receptor/Neuropeptide Y receptor type 2 in Human [ChEMBL: CHEMBL4018] [GtoPdb: 306] [UniProtKB: P49146] Y2 receptor in Rat [GtoPdb: 306] [UniProtKB: Q9ERC0] There should be some charts here, you may need to enable JavaScript!
Y4 receptor/Neuropeptide Y receptor type 4 in Human [ChEMBL: CHEMBL4877] [GtoPdb: 307] [UniProtKB: P50391] Y4 receptor in Rat [GtoPdb: 307] [UniProtKB: Q63447] There should be some charts here, you may need to enable JavaScript!
Y5 receptor/Neuropeptide Y receptor type 5 in Human [ChEMBL: CHEMBL4561] [GtoPdb: 308] [UniProtKB: Q15761] Y5 receptor in Rat [GtoPdb: 308] [UniProtKB: Q63634] There should be some charts here, you may need to enable JavaScript!
PrRP receptor in Human [GtoPdb: 337] [UniProtKB: P49683] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Y1 receptor/Neuropeptide Y receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4777] [GtoPdb: 305] [UniProtKB: P25929]
ChEMBL	Displacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometry	B	9.3	pKi	0.5	nM	Ki	J Med Chem (2013) 56: 8422-8431 [PMID:24090364]
ChEMBL	Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins	B	9.68	pKi	0.21	nM	Ki	Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082]
ChEMBL	Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay	B	10.02	pKi	0.1	nM	Ki	Eur J Med Chem (2013) 63: 85-94 [PMID:23466604]
ChEMBL	Displacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBN	B	8.59	pIC50	2.6	nM	IC50	Bioorg Med Chem Lett (2013) 23: 687-692 [PMID:23265893]
ChEMBL	Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting	B	8.92	pIC50	1.2	nM	IC50	J Nat Prod (2009) 72: 2172-2176 [PMID:19916528]
ChEMBL	Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins	B	9.66	pIC50	0.22	nM	IC50	Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082]
ChEMBL	Displacement of [125I]peptide YY from Y1 receptor in human SK-N-MC cells measured after 120 mins by scintillation counting method	B	9.68	pIC50	0.21	nM	IC50	Bioorg Med Chem (2017) 25: 471-482 [PMID:27876250]
ChEMBL	Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay	B	9.85	pIC50	0.14	nM	IC50	Eur J Med Chem (2013) 63: 85-94 [PMID:23466604]
ChEMBL	Binding affinity to human neuropeptide Y1 receptor by radioligand displacement assay	B	10.15	pIC50	0.07	nM	IC50	Bioorg Med Chem (2013) 21: 2764-2771 [PMID:23582449]
Y1 receptor in Rat [GtoPdb: 305] [UniProtKB: P21555]
GtoPdb	-	-	10.5	pKi	-	-	-	Peptides (1997) 18: 397-401 [PMID:9145427]
GtoPdb	-	-	8.8	pIC50	-	-	-	Mol Pharmacol (1992) 41: 817-21 [PMID:1316999]
Y2 receptor/Neuropeptide Y receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4018] [GtoPdb: 306] [UniProtKB: P49146]
ChEMBL	Displacement of Cy5-pNPY from human Y2 receptor expressed in CHO cells after 90 to 120 mins by flow cytometry	B	9.1	pKi	0.8	nM	Ki	J Med Chem (2013) 56: 8422-8431 [PMID:24090364]
GtoPdb	-	-	9.5	pKi	-	-	-	Mol Pharmacol (1996) 49: 224-8 [PMID:8632753]; J Biol Chem (1995) 270: 26758-61 [PMID:7592910]
ChEMBL	Binding affinity to human neuropeptide Y receptor type 2 by radioligand displacement assay	B	10.12	pKi	0.08	nM	Ki	Eur J Med Chem (2013) 63: 85-94 [PMID:23466604]
ChEMBL	Compound was evaluated for its inhibitory activity against Y2 receptor of rabbit kidney membrane	B	9.3	pIC50	0.5	nM	IC50	Bioorg Med Chem Lett (1993) 3: 937-942
ChEMBL	Binding affinity to human neuropeptide Y receptor type 2 by radioligand displacement assay	B	9.72	pIC50	0.19	nM	IC50	Eur J Med Chem (2013) 63: 85-94 [PMID:23466604]
ChEMBL	Binding affinity to human neuropeptide Y2 receptor by radioligand displacement assay	B	10.05	pIC50	0.09	nM	IC50	Bioorg Med Chem (2013) 21: 2764-2771 [PMID:23582449]
ChEMBL	Displacement of [125I]peptide YY from Y2 receptor in human KAN-TS cells measured after 60 mins by scintillation counting method	B	10.55	pIC50	0.03	nM	IC50	Bioorg Med Chem (2017) 25: 471-482 [PMID:27876250]
Y2 receptor in Rat [GtoPdb: 306] [UniProtKB: Q9ERC0]
GtoPdb	-	-	9.4	pKi	-	-	-	Mol Pharmacol (2001) 60: 124-34 [PMID:11408607]
Y4 receptor/Neuropeptide Y receptor type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4877] [GtoPdb: 307] [UniProtKB: P50391]
ChEMBL	Displacement of Cy5-[K4]hPP from human Y4 receptor expressed in CHO cells after 90 to 120 mins by flow cytometry	B	6.55	pKi	282	nM	Ki	J Med Chem (2013) 56: 8422-8431 [PMID:24090364]
GtoPdb	-	-	8	pKi	-	-	-	J Biol Chem (1995) 270: 29123-8 [PMID:7493937]
ChEMBL	Agonist activity at human Y4 receptor expressed in sf9 cells assessed as hydrolysis of [gamma-33P]GTP after 2 mins by scintillation counting analysis	B	6.38	pEC50	417	nM	EC50	J Med Chem (2013) 56: 8422-8431 [PMID:24090364]
Y4 receptor in Rat [GtoPdb: 307] [UniProtKB: Q63447]
GtoPdb	-	-	6.4	pKi	-	-	-	Peptides (1997) 18: 609-12 [PMID:9210181]
GtoPdb	-	-	8.8	pKi	-	-	-	Peptides (1997) 18: 397-401 [PMID:9145427]; Peptides (1997) 18: 609-12 [PMID:9210181]
Y5 receptor/Neuropeptide Y receptor type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4561] [GtoPdb: 308] [UniProtKB: Q15761]
ChEMBL	Displacement of Cy5-pNPY from human Y5 receptor expressed in human HEC-1B cells after 90 to 120 mins by flow cytometry	B	8.66	pKi	2.2	nM	Ki	J Med Chem (2013) 56: 8422-8431 [PMID:24090364]
GtoPdb	-	-	9.1	pKi	-	-	-	J Biol Chem (1996) 271: 26315-9 [PMID:8824284]
ChEMBL	Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK293 cell membranes.	B	8.52	pIC50	3	nM	IC50	J Med Chem (2000) 43: 346-350 [PMID:10669561]
Y5 receptor in Rat [GtoPdb: 308] [UniProtKB: Q63634]
GtoPdb	-	-	9.3	pKi	-	-	-	J Biol Chem (1996) 271: 26315-9 [PMID:8824284]
PrRP receptor in Human [GtoPdb: 337] [UniProtKB: P49683]
GtoPdb	-	-	5.4	pKi	-	-	-	Genomics (2005) 85: 688-703 [PMID:15885496]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]