JNJ-37822681 [Ligand Id: 14136] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3234237 (Jnj-37822681, JNJ-37822681) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| GtoPdb | - | - | 6.8 | pKi | 158 | nM | Ki | J Med Chem (2014) 57: 3450-63 [PMID:24666157] |
| ChEMBL | Displacement of [3H]methylspiperone from human D2L receptor expressed in HEK cell membrane after 90 mins by scintillation counting analysis | B | 6.8 | pKi | 158 | nM | Ki | J Med Chem (2014) 57: 3450-3463 [PMID:24666157] |
| D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
| ChEMBL | Displacement of [3H]methylspiperone from human D3 receptor expressed in HEK293 cell membrane after 90 mins by scintillation counting analysis | B | 5.94 | pKi | 1159 | nM | Ki | J Med Chem (2014) 57: 3450-3463 [PMID:24666157] |
| Kv7.3 in Human [GtoPdb: 562] [UniProtKB: O43525] | ||||||||
| GtoPdb | Determined in CHO cells expressing KCNQ3A315T Kv7.3 channel subunits | - | 5.7 | pEC50 | 2000 | nM | EC50 | Br J Pharmacol (2025) null: null [PMID:40702669] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
