EM127 [Ligand Id: 13979] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL5439323 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| SET and MYND domain containing 3/Histone-lysine N-methyltransferase SMYD3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2321643] [GtoPdb: 3313] [UniProtKB: Q9H7B4] | ||||||||
| ChEMBL | Binding affinity to full length recombinant SMYD3 (unknown origin) overexpressed in Escherichia coli Rosetta cells assessed as dissociation constant by SPR analysis | B | 4.89 | pKd | 13000 | nM | Kd | Eur J Med Chem (2022) 243: 114683-114683 [PMID:36116234] |
| GtoPdb | - | - | 5.21 | pKi | 6110 | nM | Ki | Eur J Med Chem (2022) 243: 114683 [PMID:36116234] |
| ChEMBL | Binding affinity to full length recombinant SMYD3 (unknown origin) overexpressed in Escherichia coli Rosetta cells assessed as inhibition constant measured after 1 hr by LC-MS analysis | B | 5.21 | pKi | 6110 | nM | Ki | Eur J Med Chem (2022) 243: 114683-114683 [PMID:36116234] |
| ChEMBL | Inhibition of full length recombinant SMYD3 (unknown origin) measured at 24 hrs | B | 6.43 | pIC50 | 370 | nM | IC50 | Eur J Med Chem (2022) 243: 114683-114683 [PMID:36116234] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
