cofrogliptin [Ligand Id: 13765] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4646510 (Cofrogliptin, Cofrogliptina, Cofrogliptine, Haisco hsk 7653) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| dipeptidyl peptidase 4/Dipeptidyl peptidase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487] | ||||||||
| ChEMBL | Inhibition of human recombinant DPP4 incubated for 15 mins using Gly-Pro-7-AMC substrate | B | 8.38 | pIC50 | 4.2 | nM | IC50 | J Med Chem (2020) 63: 7108-7126 [PMID:32452679] |
| ChEMBL | Inhibition of DPP4 (unknown origin) | B | 8.38 | pIC50 | 4.18 | nM | IC50 | Eur J Med Chem (2024) 272: 116464-116464 [PMID:38704940] |
| GtoPdb | - | - | 8.38 | pIC50 | 4.2 | nM | IC50 | J Med Chem (2020) 63: 7108-7126 [PMID:32452679] |
| dipeptidyl peptidase 8/Dipeptidyl peptidase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4657] [GtoPdb: 2356] [UniProtKB: Q6V1X1] | ||||||||
| ChEMBL | Inhibition of human recombinant DPP8 incubated for 15 mins using Gly-Pro-7-AMC substrate | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2020) 63: 7108-7126 [PMID:32452679] |
| dipeptidyl peptidase 9/Dipeptidyl peptidase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4793] [GtoPdb: 2357] [UniProtKB: Q86TI2] | ||||||||
| ChEMBL | Inhibition of human recombinant DPP9 incubated for 15 mins using Gly-Pro-7-AMC substrate | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2020) 63: 7108-7126 [PMID:32452679] |
| Kv11.1/Voltage-gated inwardly rectifying potassium channel KCNH2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG by manual whole-cell patch-clamp assay | B | 4.52 | pIC50 | >30000 | nM | IC50 | J Med Chem (2020) 63: 7108-7126 [PMID:32452679] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
