T16Ainh-A01 [Ligand Id: 13563] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1299863 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CaCC/Anoctamin-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2046267] [GtoPdb: 708] [UniProtKB: Q5XXA6] | ||||||||
| GtoPdb | Inhibition of TMEM16A-mediated chloride current in FRT cells | - | 6 | pIC50 | ~1000 | nM | IC50 | J Enzyme Inhib Med Chem (2016) 31: 1362-8 [PMID:26796863] |
| ChEMBL | Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by ATP addition by short-circuit current assay | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (2017) 60: 4626-4635 [PMID:28493701] |
| Anoctamin-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105767] [UniProtKB: Q9NQ90] | ||||||||
| ChEMBL | Inhibition of TMEM16B (unknown origin) expressed in FRT cells assessed as reduction of ATP-induced chloride conductance preincubated for 20 mins followed by ATP addition by short-circuit current assay | B | 5.4 | pIC50 | 4000 | nM | IC50 | J Med Chem (2017) 60: 4626-4635 [PMID:28493701] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
