neorauflavane [Ligand Id: 13514] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL3747057
There should be some charts here, you may need to enable JavaScript!
  • tyrosinase in Human [GtoPdb: 2643] [UniProtKB: P14679]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Tyrosinase in Agaricus bisporus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3318] [UniProtKB: O42713]
ChEMBL Competitive inhibition of diphenolase activity of mushroom tyrosinase using L-DOPA as substrate preincubated for 5 to 60 mins by Lineweaver-Burk and Dixon plot analysis B 6.89 pKi 130 nM Ki Bioorg Med Chem (2016) 24: 153-159 [PMID:26706112]
ChEMBL Competitive inhibition of monophenolase activity of mushroom tyrosinase using L-tyrosine as substrate preincubated for 5 to 60 mins by Lineweaver-Burk and Dixon plot analysis B 7.72 pKi 19 nM Ki Bioorg Med Chem (2016) 24: 153-159 [PMID:26706112]
ChEMBL Time dependent inhibition of monophenolase activity of mushroom tyrosinase using L-tyrosine as substrate measured every 30 secs by Morrison and Walsh plot analysis B 8.83 pKi 1.48 nM Ki Bioorg Med Chem (2016) 24: 153-159 [PMID:26706112]
ChEMBL Inhibition of diphenolase activity of mushroom tyrosinase using L-DOPA as substrate preincubated with substrate for 10 mins followed by protein addition measured after 15 mins by spectrophotometric analysis B 6.3 pIC50 500 nM IC50 Bioorg Med Chem (2016) 24: 153-159 [PMID:26706112]
ChEMBL Inhibition of monophenolase activity of mushroom tyrosinase using L-tyrosine as substrate preincubated with substrate for 10 mins followed by protein addition measured after 15 mins by spectrophotometric analysis B 7.52 pIC50 30 nM IC50 Bioorg Med Chem (2016) 24: 153-159 [PMID:26706112]
tyrosinase in Human [GtoPdb: 2643] [UniProtKB: P14679]
GtoPdb - - 7.52 pIC50 30 nM IC50 Bioorg Med Chem (2016) 24: 153-9 [PMID:26706112]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]