α-mangostin derivative 4e [Ligand Id: 13470] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4471352 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| phosphodiesterase 4B/3`,5`-cyclic-AMP phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343] | ||||||||
| ChEMBL | Inhibition of human PDE4B2 (152 to 487 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cAMP as substrate incubated for 15 mins by liquid scintillation counting method | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2020) 63: 3370-3380 [PMID:32115956] |
| ChEMBL | Inhibition of human PDE4B1 (1 to 736 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cAMP as substrate incubated for 15 mins by liquid scintillation counting method | B | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (2020) 63: 3370-3380 [PMID:32115956] |
| phosphodiesterase 4D/3`,5`-cyclic-AMP phosphodiesterase 4D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499] | ||||||||
| ChEMBL | Inhibition of PDE4D2 (86-413) (unknown origin) expressed in Escherichia coli BL21 assessed as using [3H]-cAMP as substrate measured for 15 mins by liquid scintillation counting analysis | B | 7.72 | pIC50 | 19 | nM | IC50 | J Med Chem (2021) 64: 13736-13751 [PMID:34520193] |
| ChEMBL | Inhibition of human PDE4D2 (86 to 413 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cAMP as substrate incubated for 15 mins by liquid scintillation counting method | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (2020) 63: 3370-3380 [PMID:32115956] |
| GtoPdb | Inhibition of PDE4D2 | - | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (2020) 63: 3370-3380 [PMID:32115956] |
| phosphodiesterase 10A/cAMP and cAMP-inhibited cGMP 3`,5`-cyclic phosphodiesterase 10A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4409] [GtoPdb: 1310] [UniProtKB: Q9Y233] | ||||||||
| ChEMBL | Inhibition of human PDE10A2 (449 to 770 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cAMP as substrate incubated for 15 mins followed by substrate addition by liquid scintillation counting method | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2020) 63: 3370-3380 [PMID:32115956] |
| phosphodiesterase 2A/cGMP-dependent 3`,5`-cyclic phosphodiesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408] | ||||||||
| ChEMBL | Inhibition of human PDE2A (580 to 919 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cGMP as substrate incubated for 15 mins by liquid scintillation counting method | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2020) 63: 3370-3380 [PMID:32115956] |
| phosphodiesterase 3A/cGMP-inhibited 3`,5`-cyclic phosphodiesterase 3A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432] | ||||||||
| ChEMBL | Inhibition of human PDE3A (679 to 1087 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cAMP as substrate incubated for 15 mins by liquid scintillation counting method | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2020) 63: 3370-3380 [PMID:32115956] |
| phosphodiesterase 5A/cGMP-specific 3`,5`-cyclic phosphodiesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074] | ||||||||
| ChEMBL | Inhibition of human PDE5A1 (535 to 860 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cGMP as substrate incubated for 15 mins by liquid scintillation counting method | B | 5.47 | pIC50 | 3390 | nM | IC50 | J Med Chem (2020) 63: 3370-3380 [PMID:32115956] |
| phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3`,5`-cyclic nucleotide phosphodiesterase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4425] [GtoPdb: 1295] [UniProtKB: Q01064] | ||||||||
| ChEMBL | Inhibition of human PDE1B (10 to 487 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cAMP as substrate incubated for 15 mins by liquid scintillation counting method | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2020) 63: 3370-3380 [PMID:32115956] |
| phosphodiesterase 7A/High affinity 3`,5`-cyclic-AMP phosphodiesterase 7A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3012] [GtoPdb: 1305] [UniProtKB: Q13946] | ||||||||
| ChEMBL | Inhibition of human PDE7A1 (130 to 482 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cAMP as substrate incubated for 15 mins by liquid scintillation counting method | B | 6.21 | pIC50 | 620 | nM | IC50 | J Med Chem (2020) 63: 3370-3380 [PMID:32115956] |
| phosphodiesterase 8A/High affinity cAMP-specific and IBMX-insensitive 3`,5`-cyclic phosphodiesterase 8A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4640] [GtoPdb: 1307] [UniProtKB: O60658] | ||||||||
| ChEMBL | Inhibition of human PDE8A1 (480 to 820 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cAMP as substrate incubated for 15 mins by liquid scintillation counting method | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2020) 63: 3370-3380 [PMID:32115956] |
| phosphodiesterase 9A/High affinity cGMP-specific 3`,5`-cyclic phosphodiesterase 9A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3535] [GtoPdb: 1309] [UniProtKB: O76083] | ||||||||
| ChEMBL | Inhibition of human PDE9A2 (181 to 506 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cGMP as substrate incubated for 15 mins by liquid scintillation counting method | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2020) 63: 3370-3380 [PMID:32115956] |
| Kv11.1/Voltage-gated inwardly rectifying potassium channel KCNH2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG expressed in CHO cells by automated patch clamp electrophysiology | B | 4.52 | pIC50 | >30000 | nM | IC50 | J Med Chem (2020) 63: 3370-3380 [PMID:32115956] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
